Synthesis of the Host-specific Toxins, AK- and AF-toxin
| Project/Area Number |
61571007
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Nagasaki University |
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Principal Investigator |
IRIE Hiroshi Professor, Nagasaki University, 薬学部, 教授 (00025686)
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| Co-Investigator(Kenkyū-buntansha) |
UENO Tamio Associate Professor, Kyoto University, 農学部, 助教授 (20026579)
TAKEDA Sigeko Research Assistant, Nagasaki University, 薬学部, 助手 (50039640)
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1987: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1986: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Total synthesis of natural products / Host-specific toxins / Nijisseiki / Stereostructure / 不斉源 / 植物病原菌 / 宿主特異的毒性 / 二十世紀黒斑病 / 全合成 / 不斉合成原料としてのビタミン C |
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| Research Abstract |
Total synthesis of the methyl esters of AK-toxin II and AF-toxin IIa and IIc, the host-specific toxins for Japanease pear Nijisseiki, was accomplished by starting from Vitamin C as a chiral starting material. Investigation of biological activities of several kinds of the intermediates prepared on the course of the synthesis confirmed that the stereochemistry of two chiral centers in the trienoic acid moiety of these toxins has tight relationship with toxic properties of the toxins. Futhermore, the synthesis revealed the availability of Vitamin C to synthesis of natural products as an appropriate chiral pool.
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Report
(2 results)
Research Products
(7 results)
