| Project/Area Number |
61571019
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Kyoto Pharmaceutical University |
|---|
Principal Investigator |
IKEFA Masazumi Kyoto Pharmaceutucal University, 薬学部, 教授 (30028857)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ISHIBASHI Hiroyuki Kyoto Pharmaceutical University, 薬学部, 助教授 (70028869)
|
|---|
| Project Period (FY) |
1986 – 1987
|
| Project Status |
Completed (Fiscal Year 1987)
|
| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1987: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1986: ¥1,600,000 (Direct Cost: ¥1,600,000)
|
|---|
| Keywords | L-prolinol / pyrrolizidine alkaloid / trachetanthamidine / helitridane / pseudoheliotridane / rasical cyclization / ブチロラクタム |
|---|
| Research Abstract |
1. (-)-Tracheranthamidine was synthesized in an oprically active form by olefin by olefin cyclization of 2-(1-propenyl)pyrrolysyl-<alpha>-methylsulfinylacetamide as the key step. 2. Formal total synthesis of <plus-minus>-psudoheliotridane was achieved by radical cyclication of the N-(2-vinylpyrrolidyl)-<alpha>-chloro-<alpha>-(methylsulfinyl)acetamide as the key step. 3. Treatment of N-(2-vinylpyrrolidyl)-<alpha>-methylthioacetamide whth sodium hydride in tetrahydrofuran gave the tetrahydro-2-methylthioprrolizan-3-one.
|
