Synthetic Studies on the Biologically Active Pyrrolizadine Derivatives Using L-Prolin as a Starting Material
| Project/Area Number |
61571019
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
IKEFA Masazumi Kyoto Pharmaceutucal University, 薬学部, 教授 (30028857)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIBASHI Hiroyuki Kyoto Pharmaceutical University, 薬学部, 助教授 (70028869)
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1987: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1986: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | L-prolinol / pyrrolizidine alkaloid / trachetanthamidine / helitridane / pseudoheliotridane / rasical cyclization / ブチロラクタム |
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| Research Abstract |
1. (-)-Tracheranthamidine was synthesized in an oprically active form by olefin by olefin cyclization of 2-(1-propenyl)pyrrolysyl-<alpha>-methylsulfinylacetamide as the key step. 2. Formal total synthesis of <plus-minus>-psudoheliotridane was achieved by radical cyclication of the N-(2-vinylpyrrolidyl)-<alpha>-chloro-<alpha>-(methylsulfinyl)acetamide as the key step. 3. Treatment of N-(2-vinylpyrrolidyl)-<alpha>-methylthioacetamide whth sodium hydride in tetrahydrofuran gave the tetrahydro-2-methylthioprrolizan-3-one.
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Report
(2 results)
Research Products
(12 results)
