| Project/Area Number |
61571026
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | University of Tokyo |
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Principal Investigator |
NAKANISHI Mamoru University of Tokyo, Faculty of Pharmaceutical Sciences, (Instructor), 薬学部, 助手 (90090472)
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| Project Period (FY) |
1986 – 1987
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| Project Status |
Completed (Fiscal Year 1987)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1986: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | T-cell / Calcium ions / MHC / Stopped-flow fluorometry / 膜流動性 / T細胞 / 細胞内情報伝達 / 免疫応答 / ヘルパーT細胞 |
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| Research Abstract |
We have studied using stopped-flow fluorometry, the initial step of the increase in cytoplasmic free calcium ions in T suppressor cells (Ts) and T helper cells (Th) after their interactions. When Th, Ts and the antigen-presenting cells had identical MHC-restriction and antigen-specificity, the increase in cytoplasmic free calcium ions, which is an intracellular messenger for activation, occurred both in Th cells after they bound to the antigen-presenting cells. Further, the activated Ts cells inhibited the increase of cytoplasmic free calcium ions in Th cells. However, MHC-restriction of Ts cells was not always apparent in the inhibition of the increase of cytpplasmic free calcium ions in Th cells. On the contrary, the actiyated Th cells were not able to inhibit the increase of cytoplasmic free calcium ions in Ts cells.
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