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Age-related alteration in adrenoceptor and its physiological responses.

Research Project

Project/Area Number 61571097
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 応用薬理学・医療系薬学
Research InstitutionSapporo Medical College

Principal Investigator

OHSHIKA Hideyo  Professor of Pharmacology, Sapporo Medical College, 医学部, 教授 (50045358)

Co-Investigator(Kenkyū-buntansha) MIYAMOTO Atsushi  Instructor of Pharmacology, Sapporo Medical College, 医学部, 助手 (50166196)
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1987: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1986: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsAging / Adrenoceptor / Signal transduction / Cholesterol / phospholipid ratio / Membrane viscosity / Cerebral cortex / Parotid gland / 心室筋 / 【α_1】-アドレナリン受容体 / 〔【^3H】〕inositol phosphates / 【K^+】放出 / ラット耳下腺
Research Abstract

We investigated the relationship between the adrenoceptor signal transduction and the membrane composition in rat cerebral cortex, parotid gland and ventricular myocardium during aging. 1. Cerebral cortex: The density of specific [^3H]prazosin binding site reduced with advanced age, but the binding affinity for [^3H]prazosin did not. Norepinephrine (NE)-induced formation of [^3H]inositol phosphates increased with advanced age. The cholesterol content in membranes increased with advanced age; concomitantly, an increase of the ratio cholesterol/phspholipid was observed. The membrane viscosity as measured by using 1,6-diphenyl-1,3,5-hexatriene increased with advanced age.
2. Parotid gland: NE-induced of K^+ release from the slices reduced with advanced age. The density of specific [^3H]prazosin bindng site increased with advanced age, but the binding affinity for [^3H]prazosin did not. NE-induced formation of [^3H]inositol phosphates decreased with advanced age. No difference in isoprotere … More nol (ISO)-induced decrease in K^+ release and increase in cyclic AMP content were observed at any age examined. But the binding affinity for [^3H]dihydroalprenolol binding site reduced with advanced age, and the binding affinity for [^3H]dihydroalprenolol increased. The cholesterol content in membranes decreased with advanced age; concomitantly, a decrease of the ratio cholesterol/phospholipid was observed. The membrane viscosity decreased with advanced age.
3. Ventricular myocardium: The density of specific [^3H]prazosin binding site reduced with adanced age, and the binding affinity for [^3H]prazosin increased. NE-induced formation of [^3H]inositol phosphates decreased with advanced age. The cholsterol content decreased with advanced age; concomitantly, a decrease in the ratio cholesterol/phospholipid was observed. The membrane viscosity decreased with advanced age.
These results suggest that the both altered cholesterol/phospholipid ratio and/or membrane viscosity during aging may account for the changes in adrenoceptor signal transduction. Less

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] A.Miyamoto: Japan.J.Pharmacol.42. 63-70 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 宮本篤: 神経化学. 25. 265-267 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 大鹿英世: 日本臨牀. 44. 1527-1533 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] T.Saito: Japan.J.Pharmacol.43. 73P (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A.Miyamoto: Japan.J.Pharmacol.43. 205P (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 宮本篤: 神経化学. 26. 337-339 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A.Miyamoto: J.Neurochem.48. S88 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 宮本篤: 日薬理誌. 90. 7S (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 大鹿英世: 日本臨牀. 45 ヲ ′. 39-48 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 大鹿英世: 薬局. 38. 1619-1624 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A.Miyamoto: (J.Pharm.Pharmacol.).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A.Miyamoto: (Neurosci.Let.).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A.Miyamoto: (Neurochem.Res.).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A.Miyamoto: (Eur.J.Pharmacol.).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A.Miyamoto: (Comp.Biochem.Physiol.).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A.Miyamoto: "in:Trends in Pharmacological Research on Platelet-Activating Factor(PAF)in Japan." Ishiyaku Euroamerica Ind.,Tokyo, 12 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A. Miyamoto: "Effects of isoproterenol pretreatment on phosphatidylinositol turnover in rat parotid gland." Japan. J. Pharmacol.42. 63-70 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A. Miyamoto: "Modulation of adrenergic binding by cell membrane phospholipids." Bulletin of The Japanese Neurochemical Society. 25. 265-267 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] H. Ohshika: "The salivary secretion: Regulation of salivary secretion and receptor." The Japanese Journal of Clinical Medicine, special editing; Exocringe gland. 44. 1527-1533 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] T. Saito: "Alterations in beta-receptor function during aging in the rat cerebral cortex." Japan. J. Pharmacol.43. 73P (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A. Miyamoto: "Age-related changes in <alpha>_1-adrenoceptor function in rat parotid gland." Japan. J. Pharmacol.43. 205P (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A. Miyamoto: "<alpha>_1-Adrenergic stimulation of arachidonic acid release and inositol phosphate formation in rat parotid cells." Bulletin of The Japanese Neurochemical Society. 26. 337-339 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A. Miyamoto: "Alterations in adrenoceptor function of rat parotid gland during aging." J. Neurochem.48. S88 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A. Miyamoto: "Platelet-activating factor (PAF)-induced increase in salivary secretion." Folia pharmacol. japon.90. 7S (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] H. Ohshika: "The transport in salivary gland." The Japanese Journal of Clinical Medicine, a new edition; The body fluids. 45. 39-48 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] H. Ohshika: "The adrenoceptor and side effects." The Journal of Paractical Pharmacy. 38. 1619-1624 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A. Miyamoto: "Potentiation of _1-adrenergic responses in rat parotid gland by dibutyryl cyclic AMP treatement." Submitted to J. Pharm. Pharmacol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A. Miyamoto: "Membrane viscosity correlate with _1-adrenergic responsiveness of theaged rat cerebral cortex." Submitted to Neurosci. Let.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A. Miyamoto: "Age-related altereation in _1-adrenergic singnal transduction of ratparotid gland." Submitted to Neurochem. Res.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A. Miyamoto: "Age-related changes in [^3H]prazosin binding and phosphoinositide hydrolysis in rat ventricular myocardium." Submitted to Eur. J. Pharmacol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A. Miyamoto: "Aging and -adrenergic functions of rat parotid gland." Submitted to Comp. Biochem. Physiol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] A. Miyamoto: Trends in Pharmacological Research on Platelet-Activating Factor (PAF)in Japan.Ishiyaku Euroamerica Inc., Tokyo, in press (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Atsushi Miyamoto: Mechanisms of Ageing and Development.

    • Related Report
      1986 Annual Research Report
  • [Publications] 大鹿英世: 日本臨床. 夏季増刊. (1987)

    • Related Report
      1986 Annual Research Report
  • [Publications] Atsushi Miyamoto: Japanese Journal of Pharmacology. 42. 63-70 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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