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Development and Its application of Calcium Phosphate Glass-Ceramics for biomaterials

Research Project

Project/Area Number 61850141
Research Category

Grant-in-Aid for Developmental Scientific Research

Allocation TypeSingle-year Grants
Research Field 無機工業化学
Research InstitutionNagoya Institute of Technology

Principal Investigator

ABE Yoshihiro  Nagoya Institute of Technology, Professor, 工学部, 教授 (90024223)

Co-Investigator(Kenkyū-buntansha) WATANABE Akira  Kyushu Refractories Co.Ltd. Research head, 研究部, 研究部長
TSUTSUMI Sadami  Kyoto University Associate Professor(Research Center for Medical polymers and Bi, 医用高分子研究センター, 助教授 (00028739)
HOSONO Hideo  Nagoya Institute of Technology, Assistant(instructor), 工学部, 助手 (30157028)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 1988: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1987: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1986: ¥3,000,000 (Direct Cost: ¥3,000,000)
KeywordsCalcium phosphate / Glass-ceramics / Impalntation / Artificial bone / Artificial dental crown / CaO-TiO_2-P_2O_5,CaO-P_2O_5 / CaO-P_2O_5系 / 体積結晶化 / 一方向結晶化 / 多孔質結晶化ガラス / CaO-TiO_2-P_2O_5結晶化ガラス / 多孔質リン酸カルシウム結晶化ガラス / リン酸カルシウム / 結晶化ガラス / 核形成剤 / 配向結晶化
Research Abstract

The purpose of this investigation is to develop new calcium phosphate glass-ceramics for sugical and dental use, and to examine how they are biocompatible or not when implanted. Two kinds of glass-ceramics have been developed; one is unidirectionally crystallized CaO-P_2O_5 glass-ceramics, and the other is randomly crystallized glass-ceramics based on mainly calcium phosphate.
(1). The unidirectionally crystallized glass-ceramics exhibit high bending strength and high toughness, and good bonding properties with natural bone. We believe that bone implant materials should have low Young's modulus as nearlly as natural bone's; from this view point, the unidirectionally crystallyzed glass-ceramics are to be preferable. However, they have weak points in that chemical durability is not so high to be decreased in mechanical strength with increasing time.
(2). The randomly crystallized glass-ceramics in the system of CAO-A1_2O_3-P_2O_5 and CaO-TiO_2-P_2O_5 have high precise castability(shapability) when cast from the molten state. These are suitable for artificial dental crown materials, because of its high shapability, high mechanical strength,as well as high chemical durability. Micro-porous glass-ceramics have been developed by leaching with acid Na_2O-CaO-TiO_2-P_2O_5 glass-ceramics.
(3). Biocompatibility has been examined for calcium phosphate glass-ceramics by medical researchers.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] Y.Abe: Phosphorus and Sulfur. 30. 337-340 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] H.Hosono: Journal of Materials Science Letters. 6. 394-396 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] C.P.A.T.Klein: Biomaterials. 8. 234-236 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Y.Abe: Proceedings of the International Symposium on Bioceramics'88. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] H.Hosono: Journal of the American Ceramic Society. 72. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] A.Watanabe: Journal of the American Ceramic Society. 72. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 和田真: Orthopaedic Ceramic Implants. 5. 201-205 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 尾崎隆伸: 中部日本整形外科災害外科学会雑誌. 29. 1735-1734 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 尾崎隆伸: 中部日本整形外科災害外科学会雑誌. 31. 632-633 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 長瀬雄: Orthopaedic Ceramic Implants. 8. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Y.Abe; H.Hosono; M.Hosoe: "Development of Calcium Phosphate Glass-Ceramics for Surgical and and Dental Use" Phosphorus and Sulfur. 30. 337-340 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] H.Hosono; Y.Shimizu; H.Ohsato; Y.Abe: "Effect of Crystallization Temperature and Additives on the Orientation Degree of Calcium Phosphate Glass-Ceramics Prepared by Unidirectional Crystallization" Journal of Materials Science Letters. 6. 394-396 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] C.P.A.T.Klein; Y.Abe; H.Hosono; K.de Groot: "Comparison of Calcium Phosphate Glass-Ceramics with Apatite Ceramics Implanted in Bone. An Interface Study II" Biomaterials. 8. 234-236 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Y.Abe; H.Hosono; M.Hosoe; S.Tsutsumi; A.Shinya; S.Yokozuka: "Preparation and Properties of Calcium Phosphate Glass-Ceramics for Castable Dental Crown" Proceedings of the International Symposium on Bioceramics'88. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] H.Hosono; Z.Zhang; Y.Abe: "Porous Glass-Cramics in the CaO-TiO_2-P_2O_5 System" Jounal of the American Ceramic Society. 72. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Y.Abe;H.Hosono;M.Hosoe;S.Tsutsumi;A.Shinya;S.Yokozuka: Proceedings of the International Symposium on Bioceramics 188(1988). (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] H.Hosono;Z.Zhang;Y.Abe: Journal of the American Ceramic Society. 72. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] A.Watanabe;M.Mitsudon;S.Kihara;Y.Abe: Journal of the American Ceramic Society. 72. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 長瀬満雄,藍原繁彦,千木良正機,宇田川英一,阿部良弘: Orthopaedie Ceramic Implants. 8. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Y.ABE;H.HOSONO;M.HOSOE: Proceedlings of Tenth International Conference of Phosphorus Chemistry. (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] H.HOSONO;Y.SHIMIZU;H.OHSATO;Y.ABE: Journal of Materials Science Cetters.

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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