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Basic study for the development of the instrument measuring water content of the skin surface stratum corneum with high frequency

Research Project

Project/Area Number 61870041
Research Category

Grant-in-Aid for Developmental Scientific Research

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

TAGAMI Hachiro  Tohoku University School of Medicine, 医学部, 教授 (60026911)

Co-Investigator(Kenkyū-buntansha) ROKUGO Masakazu  Tohoku University School of Medicine, 医学部附属病院, 助手 (60183711)
HASHIMOTO Kumiko  Tohoku University School of Medicine, 医学部附属病院, 助手 (00201707)
TADAKI Takayoshi  Tohoku University School of Medicine, 医学部附属病院, 助手 (40188256)
OBATA Masaaki  Tohoku University School of Medicine (20124563)
八丁目 直寛  東北大学, 医学部附属病院, 助手 (30125637)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥10,900,000 (Direct Cost: ¥10,900,000)
Fiscal Year 1988: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1987: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1986: ¥8,000,000 (Direct Cost: ¥8,000,000)
KeywordsStratum corneum / hydration / water-holding capacity / high frequency / simulation model / 生体シミュレイション / モデル / 角層水分 / 生体シミュレイションモデル / 生体シムレイションモデル / 経表皮水分裏失
Research Abstract

Because of its efficient water-holding capacity, normal stratum corneum (SC) can stay soft and flexible under any environmental conditions. However, there is thought to be a great difference in water content within the SC between the lowermost layer that faces the wet underlying living tissue and the superficial portion of the SC that is exposed to the relatively dry ambient atmosphere. We have developed a method to measure the hydration state of the skin surface employing skin conductance of high-frequency current of 3.5 MHz. However, the real depth of penetration of thie electric current into the skin was not fully determined in vivo.
In the present study we devised a simple and convenient in vitro model of the SC that simulates the in vivo setting of the SC. It consists of an isolated sheet of SC whose lower surface covers a pad of water-saturated filter paper, while the upper surface is exposed to the ambient atmosphere. By placing this model in environments with different relative … More humidities, we confirmed that the recorded conductance values correlated well with the actual water content of the SC (r=0.94).
Using a model having 5 layers of SC sheets, the water content of the innermost portion of the SC was estimated to be equivalent to about 90% of its dry weight, this level of water content remaining relatively constant over a wide range of ambient relative humidities except in extraordinary humid environments above 90% relative humidity when water began to accumulate excumulate excessively in the whole SC. In this 5-SC-sheet model, it was clearly demonstrated that there was an almost straight water concentration greadient from the lowermost layer to the uppermost layer of the SC.
We also confirmed that the skin conductance of the high grequency current correlated well with the water content of the superficial portion of the SC as well as with that of the whole SC, i.e. , is is a good parameter of the hydration state fo the superficial layer of the SC. In addition, we found that the electric current penetrates at least 5mm deep into the underlying water-saturated cutaneous tissue to show an optimal reading. Less

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] 佐々木由美子、橋本久美子、田上八朗: 日本香粧品科学会誌. 12. 90-94 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 只木行啓、田上八朗: 西日本皮膚科. 50. 450-456 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 田上八朗: 日本香粧品科学会誌. 12. 261-264 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] M.Obata et al.: Journal of Investigative Dermatology. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 田上八朗: "生体角層の機能測定法(現代皮膚科学大系、年刊版 88-A)" 中山書店, 10 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] H.Tagami: "A ging and the hydration state of the sk in.In:Cutaneous Aging" University of Tokyo Press, 10 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] H.Tagami: " Impedence measurements for evaluation of the hydration state of the skin surface.In:Cutaneous Investigation in Health and Diseased" Marcel Dekker Inc,New York, 1988

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hashimoto,K; Obata,M; Tagami,H: "Electrical measurement of the water content of the skin. Comparison between skin surface hygrometer and corneometer in evaluation of the skin surface hydration state." Journal of Japanese Cosmetic Science Society. 11. 252-258 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Sasaki,Y; Hashimoto,K; Tagami,H: "The study of the function of the stratum corneum in the aged skin" Journal of Japanese Cosmetic Science Society. 12. 90-94 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tadaki,T; Tagami,H: "The effects of topical application of 1,24-dihydroxycholecarciferol on the function of stratum corneum." Nishinihon Journal of Dermatology. 50. 450-456 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tagami,H: "Impedance method for measurement of skin surface hydration state" Journal of Japanese Cosmetic Science Society. 12. 261-264 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Obata,M; Tagami,H: "Electrical determination of water content and concentration profile in a simulation model of in vivo stratum corneum" Journal of Investigative Dermatology. 92. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tagami,H: Impedance measurement for evaluation of the hydration state of the skin surface In: Leveque J-L(Ed): Cutaneous Investigation in Health and Disease.Marcel Dekker, Inc, 79-111 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 佐々木由美子,橋本久美子,田上八朗: 日本香粧品科学会誌. 12. 90-94 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 只木行啓,田上八朗: 西日本皮膚科. 50. 450-456 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] M.Obata;et al.: Journal of Investigative Dermatology. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 田上八朗: 日本香粧品科学会誌. 12. 261-264 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 田上八朗: "生体角層の機能測定法 久木田淳他篇 現代皮膚科学大系 年刊版88ーA" 中山書店, 55-65 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] H.Tagami: "Aging and the hydration state of the skin.In;Kligman AM.Takase Y.(Eds);Cutaneous Aging" University of Tokyo Press, 99-109 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] H.Tagami: "Impedence measurements for evaluation of the hydration state of the skin surface.In:Leveque J-L(Ed):Cutaneous Investigation in Health and Diseased" Marcel Dekker Inc,New York, 79-111 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 小幡正明,六郷正和,田上八朗: 皮膚科紀要. 81. 595-605 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Tagami,H.;ed Leveque JL: "CUTANEOUS INVESTIGATION IN HEALTH AHD DISEASE;NONINVASIVE METHODS AND INSTRUMENTATION.Chapter for"Impedance measurement for the evaluation of hydration state of the skin surface"" Marcel Dekker Inc,

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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