| Project/Area Number |
61870044
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Shimane Medical University |
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Principal Investigator |
KATO Hirokazu Shimane Medical University.Associate Professor, 医学部, 助教授 (60127511)
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| Co-Investigator(Kenkyū-buntansha) |
KASAI Toshifumi Shimane Medical University.Technical Professor, 医学部, 教務員 (70194701)
UCHIDA Nobue Shimane Medical University.Physician, 医学部付属病院, 医員 (80304260)
FURUKAWA Masahiko Shimane Prefectural Central Hospital.Head Physician, 放射線科, 医長 (20165476)
ISHIDA Tetsuya Shimane Medical University.Professor, 医学部, 教授 (20030900)
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥25,000,000 (Direct Cost: ¥25,000,000)
Fiscal Year 1988: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1987: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1986: ¥20,000,000 (Direct Cost: ¥20,000,000)
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| Keywords | Hyperthermia / Heating equipment / 加温装置 / 誘導加温 / 深部加温 |
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| Research Abstract |
To deliver electromagnetic energy to a deep portion of the body. RF at a lower frequency is needed. Appricators driven at lower frequency include 1) capacitive type applocator, 2)inductive applicator, 3) ridge waveguide type applicator filled with water, and 4) horn type applicator. They have their own problems so that we designed an inductive aperture-type applicator, IATA, for the purpose of resolving their problems. The applicator consists of 6 sheets of copper strips 0.3 mm in thickness. The applicator is a 3/4-turn square coil made of the strips which are bent like the shape of the Russian letter. "PI". One of the surfaces serves as an aperture. We developed heating equipment with IATA, "Inductron", for clinical use. The Inductron is driven at 13.56 MHz with a maximum power of 10 KW. The bed, the gantry, and the applicator of the Inductron are movable in various directions, so that the aperture can face any portion of the patients' body. Eighteen patients were treated with hyperthermia twice a week just after radiation therapy which was applied 5 times a week, and one patients was treated with hyperthermia alone. Four of 19 patients had metastatic skin lesions located within 0.5 cm of the skin surface. Fifteen of 19 patients had tumors located 1 to 5 cm in depth from the skin. Heat was applied to the body without contact to the applicator. The highest temperature in the tumor was 48.3゜C and the tumors were heated above 42゜C for 10 to 50 minutes. The overall respose rate is 13/19. But the response rate without the patient who had hyperthermia treatment without radiation therapy and had hyperthermia treatment less than 4 times was 12/14. We plan to treat deep seated tumors hereafter.
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