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Development of Multifunctional Hemodialyzer for Artificial Kidney Using EVAL Hollow Fiber Membrane.

Research Project

Project/Area Number 61890006
Research Category

Grant-in-Aid for Developmental Scientific Research

Allocation TypeSingle-year Grants
Research Field 広領域
Research InstitutionTechnological University of Nagaoka

Principal Investigator

IMAI Kiyokazu  professor of Technological University of Nagaoka, 工学部, 教授 (60115102)

Co-Investigator(Kenkyū-buntansha) TEZUKA Yasuyuki  Research Associate of Technological University of Nagaoka, 工学部, 助手 (80155457)
SHIOMI Tomoo  Associate Professof of Technological Univbersity of Nagaoka, 工学部, 助教授 (10134967)
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥7,800,000 (Direct Cost: ¥7,800,000)
Fiscal Year 1987: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1986: ¥5,800,000 (Direct Cost: ¥5,800,000)
KeywordsHemodialyzer of artificial Kidney / Ethylene-Vinyl Alcohol Copolymer / Hollow Fiber / Antithrombogenicity / Binding of Enzyme / Hepatin / ウレアーゼ / 人工腎臓透膜 / エチレン-ビニルアルコール共重合体
Research Abstract

This study was carried out for the purpose of development of a novel functional hemodialyzer for artificial kidney, using ethylene-vinyl alcohol copolymer (EVAL) membrane. First, as a preliminary study, some kinds of enzyme such as invertase and gulcoamylase were immobilized on the aminoacetalized EVAL membrane. The good results were obtained with respect to immobilization yield and actibvity yield as well as stabilities in storage and repeating use. Further, separability of product from substrate-product mixture was examined. Next, based on the aboce results, urease was bound to the aminoacetalized follow fiber membrane for the purpose of urea decomposition. The pH dependence of activity for the bound urease was improved compared to that for native one. In the continuous uses, also, the activity of the bound urease was kept stable. For improvement of antithrombogenicity heparin was bound to the EVAL membrane surface aminoacetalized. The amount of bouns heparin was proportional to the cation content on the membrane. Further, the time for the fibrin apperance in the plasma in which the heparinized membrane was incubate at 370゜C increased with incubation time and with the bound heparin amount. The amount of heparin released into plasma was estimated to be 0.6-1.3% against the bound heparin amount in 60-min incubation. This means that anititrombogenicity of the heparinized membrance was improved and that its property was kept durable enough. From the above results obtained in this study, developemtn of a novel functional hemodialyzer will be expected.

Report

(2 results)
  • 1987 Final Research Report Summary
  • 1986 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 今井 清和: Biotech.Bioeng.28. 198-203 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 今井 清和: Biotech.Bioeng.28. 1721-1726 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 宮 正光: 高分子論文集. 43. 659-664 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 塩見 友雄: Biotech.Bioeng.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 塩見 友雄: J.Bimed.Mat.Res.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kiyokazu Imai, Tomooshiomi, Kozo Uchida, Masamitsu miya: "Immobilization of Enzyme onto poly(ethylene-Vinyl Alcohol) Membrane." Biotechnology and Bioengineering. 28. 198-203 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kiyokazu Imai, Tomoo Shiomi, Kozo Uchida, Masamitsu Miya: "Immobilization of Enzyme into Poly(vinyl alcohol) Membrane." Biotechnology and Bioengineering. 28. 1721-1726 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masamitsu Miya, Mikitoshi Atoh, Tomoo Shiomi, Kivokazu Imai: "Immobilization of Urease onto Poly(ehtylene-co-vinyl alcohol) Hollow Fibers." Kobunshi Roubunshu. 43. 659-664 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tomooshiomi, Masao Tohyama, Mikitoshi Satoh, Masamitsu Miya, Kiyokazu Imai: "Properties of Invertase Immobilized on the Poly(ethylene-convinyl alcohol) Holle Fiber Membrane." Biotechnology and Bioengineering. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Tomoo Shiomi, Mikitoshi Satoh, Msamitsu Miya, Kiyokazu Imai, Hitoyuki Akasu, Kazuhiko Ohtake: "Binding of Heparin onto Ethylene-Vinyl Alcohol Copolymer Membrane." Journal of Biomedical Materials Research: Applied Biomaterials Section. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] K.Imai: Biothech.Bioeng.28. 198-203 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] K.Imai: Biotech.Bioeng.28. 1721-1726 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 宮正光: 高分子論文集. 43. 659-664 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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