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Studies on New World leishmaniasis and its transmission

Research Project

Project/Area Number 62043055
Research Category

Grant-in-Aid for Overseas Scientific Research

Allocation TypeSingle-year Grants
Section調査総括
Research InstitutionKochi Medical School

Principal Investigator

HASHIGUCHI Yoshihisa  Department of Parasitology, Kochi Medical School, Dochi, Japan, 医学部, 助教授 (10037385)

Co-Investigator(Kenkyū-buntansha) A ゴメス  エクアドル国熱帯医学研究所, 主任研究員
V.V コロネル  エクアドル国熱帯医学研究所, 部長
MIMORI Tatsuyuki  Department of Parasitic Diseases, Kumamoto University School of Medicine, Kumamo, 医学部, 講師 (00117384)
KAWABATA Masato  Department of Clinical Pathology, Nihon University School of Medicine, Tokyo, Ja, 医学部, 講師 (30175294)
FURUYA Masato  Institute for Laboratoey Animals, Kochi Medical School, Kochi, Japan, 医学部, 助教授 (00035437)
VICENTA Vera de Coronel  Departamento de Parasitologia, Instituto Nacional de Higiene y Medicina Tropical
GOMEZ L. Eduardo A.  Departanmento de Parasitologia, Instituto Narional de Higiene y Medicina Tropica
Project Period (FY) 1986 – 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1987: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsLeishmaniasis / sandflies / reservoirs / Leishmania isolates / Transmission / Epidemiological surveys / Skin test / ELISA
Research Abstract

In order to elucidate epidemiological features of leishmaniasis in Centeal and South Americas, field studies on several aspects of the disease were performed mainly in ecuador. The results obtained are summarized as follows:
1. According to the articles published in Ecuador to date, there may be three or foue clinical forms of the disease, cuta- neous cases (ca. 93% of total), mucocutaneous (6 or 7%), and visceral and diffuse cutaneous ones. The majority of cases reported was from the Pacific coast, followed by the Amazon. A few cases were also observed in the Andean highland or the mid-Andes.
2. We have isolated eight Leishmania stocks, five from humans and three from wild mammals. Identifications based on results of serodeme typing using monoclonal antibodies revealed that three of the five from humans areL. braziliensis panamensis and all three from wild mammals are L. mexicana amazoninsis. Some stocks from humans and mammals require further investigation until theyare fully character … More ized.
3. With regard to the vector and reservoir, one species of Lutzomyia, gomezi, and one mammalian species, Tamandua tetradac tyla, were newly implicated, in addition to species recorded already in Ecuador.
5. The skin test and ELISA used in this study were highly sensitive and specific for cutaneous and mucocutaneous forms. These diagnostic tools could be very useful in screening of thedisease in epidemiological surveys.
6. Andean Leishmaniasis (uta) in Ecuador was first described from the mid-andes (2,300-2,500 m above sea level). The suspected vector is Lutzomyia petuenses. Bacterial flora was isolated from highland and lowland leishmanial ulcers and examined thoroughly, in relation to evolution of leishmanial ulcers.
Thus, most of the findings presented here can be considered as preliminary results of the investigation. Based on these basic data obtained, we hope to further elucidate the epidemiological features of leishmaniasis in the new World, with particular reference to Ecuador, in future field research. Less

Report

(1 results)
  • 1987 Final Research Report Summary
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 橋口義久,古谷正人,三森龍之,川端真人: 寄生虫学雑誌. 36. 79 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 古谷正人,三森龍之,川端真人,橋口義久: 寄生虫学雑誌. 37. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] 川端真人,三森龍之,古谷正人,橋口義久: 熱帯医学雑誌. 16. (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Euruya,M.;Mimori,T.;V.V. de Coronel; E.A. Gomez L.;Kawabata, M.;Hashiguchi,Y.: Transactions of the Royal Society of Tropical Medicine and Hygiene.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hashiguchi,Y.;ed.: "Studies on New World Leishmaniasis and its transmission,with special reference to Ecuador" Kyowa Printing & Co. Ltd., 1-203 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hashiguchi,Y., Furuya,M., Mimori.T., Kawabata,m.: "Leishmaniasis on the Andean highlands in Ecuador" Japanese Journal of Parasitology. 36 (Suppl). 79 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Furuya,M., Mimori,T., Kawabata,M., Hashiguchi,Y.: "Results of leishmaniasis screening tset using skin test and ELISA Ecuador" Japanese Journal of Parasitology. 37 (2). (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Kawabata,M., Mimori,T., Furuya,M., Hashiguchi,Y.: "Bacterial flora isolated from liishmanial ulcer in Ecuador" Japanese Journal of Tropical Medicine and Hygiene. 16. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Furuya,M., Mimori,T., V.V. De Corones, E.A. Gomez L. , Kawabata,M., Hashiguchi,Y.: "Evaluation of skin test and ELISA in the screening of leishmaniasis in Ecuador" Transactions of the Royal Society of Tropical Medicine and Hygiene.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Hashiguchi,Y. ed.: Kyowa Printing & Co. Ltd.Studies on New World leishmaniasis and its transmission, with particular reference to Ecluador, 1-203 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary

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Published: 1987-04-01   Modified: 2016-04-21  

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