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Genetic study of salivary proteins in some populations lining in Singapore

Research Project

Project/Area Number 62043071
Research Category

Grant-in-Aid for Overseas Scientific Research

Allocation TypeSingle-year Grants
Section調査総括
Research InstitutionTokyo Dental College

Principal Investigator

SUZUKI Kazuo  professor of Tokyo Dental College, Dept. of Forensic Odontology, 歯学部, 教授 (80085703)

Co-Investigator(Kenkyū-buntansha) LIM Kheng Ann  Associate Professor of the University of Singapore Deputy Director of Medical Se, 歯学部・準教授・シンガポール政府・衛生省歯科・Deputy d, 準教授
SHINTANI Masuro  Assistant of Tokyo Dental College, Dept. of Forensic Odontology, 歯学部, 助手 (60171071)
HASHIMOTO Masatsugu  Assistant Professor of Tokyo Dental College, Dept. of Forensic Odontology, 歯学部, 講師 (50138682)
MINAGUCHI Kiyoshi  Associate Professor of Tokyo Dental College, Dept. of Forensic Odontology, 歯学部, 助教授 (00133380)
Project Period (FY) 1987
Project Status Completed (Fiscal Year 1987)
Budget Amount *help
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1987: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsPopulation genetics / Salivary genetics / Proline-rich proteins / Chinese / Malays / Indians
Research Abstract

Salivary proline-rich protein(PRP) polymorphisms were investigated in 215 Chinese, 220 Malays and 109 Indians living in Singapore. Polymorphic Pr, Pa, Db, PIf, As, Au, Ps, Gl, PmF and PmS proteins were detected. Acidic PRP were classified into 4 alleles in PRH and 3 alleles in PRH2. Ob basic PRPs, Ps, PmS and Gl were considered to be indipendent loci. Figure shows the results of each frequencies including the data of Japanese and Filipinos. Gene frequencies were compared between two races among 5 asian populations. Significant diferrences were observed between Japanese and other races, between Indians and Filipinos of PRH1 locus, between Japanese and Chinese, Malays, Filipinos, between Chinese and Malays of Ps locus, between Indians and other races of PmS locus. PRH1^4 (As) and G1^<5-8> were suggested to be Mongoloid markers, and Ps^4 to be a Malay marker. This is a first comprehensive study in salivary PRP polymorphisms of Chinese, Malays and Indians. The results shows the usefulness of using saliva as a tool for population genetical studies. Genetic distances using salivary polymorphic markers will be investigated in the future after examining Pb and Amy_1 systems.

Report

(1 results)
  • 1987 Final Research Report Summary
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] 第71次日本法医学会総会講演要旨. (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masuro, Shintani: "Salivary proline-rich protein polymorphisms in Chinese, Malays and Indians of the inhabitants in Sigapore" Annals of Human Genetics.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary
  • [Publications] Masuro, Shintani: "New alleles of salivary acidic proline-rich proteins observed in Japanese, Chinese and Malays" Annals of Human Genetics.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1987 Final Research Report Summary

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Published: 1987-04-01   Modified: 2016-04-21  

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