| Co-Investigator(Kenkyū-buntansha) |
LIM Kheng Ann Associate Professor of the University of Singapore Deputy Director of Medical Se, 歯学部・準教授・シンガポール政府・衛生省歯科・Deputy d, 準教授
SHINTANI Masuro Assistant of Tokyo Dental College, Dept. of Forensic Odontology, 歯学部, 助手 (60171071)
HASHIMOTO Masatsugu Assistant Professor of Tokyo Dental College, Dept. of Forensic Odontology, 歯学部, 講師 (50138682)
MINAGUCHI Kiyoshi Associate Professor of Tokyo Dental College, Dept. of Forensic Odontology, 歯学部, 助教授 (00133380)
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| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1987: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Research Abstract |
Salivary proline-rich protein(PRP) polymorphisms were investigated in 215 Chinese, 220 Malays and 109 Indians living in Singapore. Polymorphic Pr, Pa, Db, PIf, As, Au, Ps, Gl, PmF and PmS proteins were detected. Acidic PRP were classified into 4 alleles in PRH and 3 alleles in PRH2. Ob basic PRPs, Ps, PmS and Gl were considered to be indipendent loci. Figure shows the results of each frequencies including the data of Japanese and Filipinos. Gene frequencies were compared between two races among 5 asian populations. Significant diferrences were observed between Japanese and other races, between Indians and Filipinos of PRH1 locus, between Japanese and Chinese, Malays, Filipinos, between Chinese and Malays of Ps locus, between Indians and other races of PmS locus. PRH1^4 (As) and G1^<5-8> were suggested to be Mongoloid markers, and Ps^4 to be a Malay marker. This is a first comprehensive study in salivary PRP polymorphisms of Chinese, Malays and Indians. The results shows the usefulness of using saliva as a tool for population genetical studies. Genetic distances using salivary polymorphic markers will be investigated in the future after examining Pb and Amy_1 systems.
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