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Biochemical Studies on Multiple Forms of Tissue Kininogenases

Research Project

Project/Area Number 62045034
Research Category

Grant-in-Aid for Overseas Scientific Survey.

Allocation TypeSingle-year Grants
SectionUniversity-to-University Cooperative Research
Research InstitutionScience University of Tokyo

Principal Investigator

MORIYA Hiroshi  Science University of Tokyo, Pharmaceutical Sciences, 薬学部, 教授 (90084409)

Co-Investigator(Kenkyū-buntansha) AOKI Kazumasa  Science University of Tokyo, Pharmaceutical Sciences, 薬学部, 助手 (10184029)
KAMADA Masafumi  Science University of Tokyo, Pharmaceutical Sciences, 薬学部, 助手 (90161207)
IKEKITA Masahiko  Science University of Tokyo, Pharmaceutical Sciences, 薬学部, 講師 (70138981)
KIZUKI Kazuyuki  Science University of Tokyo, Pharmaceutical Sciences, 薬学部, 助教授 (90089326)
CHARLES C. S  ミシガン州立大学, 生化学部門, 教授
SWEELEY Charles C.  Michigan State University, Biochemistry
CHARLES C.Sw  ミシガン州立大学, 生化学, 教授
Project Period (FY) 1987 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥7,400,000 (Direct Cost: ¥7,400,000)
Fiscal Year 1989: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1988: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1987: ¥3,500,000 (Direct Cost: ¥3,500,000)
Keywordskininogenase / multiple forms / oligosaccharides structure / isoelectrophoresis / FAB-MS / autolysis loop / monoclonal antibody / kininogenase producing renal cell
Research Abstract

1. Analysis of carbohydrate structures of human urinary kininogenase in normal subject and pancreatic carcinoma, and porcine pancreatic and submaxillary kininogenases, using by fast atom bomberdment mass spectrometry. 2. Demonstration of the proteolytic prosessing of tissue prokininogenase. 3. Development of a new sensitive method for detecting tissue kininogenase. 4. Development of enzyme linked immunosorbent assay for human urinary kininogenase with monoclonal antibody. 5. Isolation of the kininogenase-producing cell from rat kidney.

Report

(2 results)
  • 1989 Final Research Report Summary
  • 1987 Final Research Report Summary
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] Masahiko Ikekita: "Human Urinary Kallikrein.II.Analysis of Asparagine-Linked Olligosaccharides by Using Lectins." Chem.Pharm.Bull.35. 2071-2078 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takuji Masunaga: "Observation of the Varied Micro-Heterogeneous Forms of Human Urinary Kallikrein Individual Excreted in Some Diseases" Jap.J.Clin.Chem.16. 8-17 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 鈴木聡: "ヒト血中に存在する組織性カリクレイン" 臨床化学. 16. 194-201 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 寺島裕夫: "ヒト膵性カリクレインの精製と性状" 日本消化器病学会雑誌. 85. 1320 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Masafumi Kamada: "Generation of α-and β-Kallikreins from Porcine Pancreatic Prokallikrein by the Action of Trypsin" Chem.Pharm.Bull.36. 4891-4899 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Masahiko Ikekita: "Characterization of N-linked Oligosaccharides of Human Urinary Kallikrein Molecules" Adv.Exp.Med.Biol.247B. 157-162 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Charles C.sweeley: "Fast Atom Bomberdment Mass Spectrometry(FAB-MS):Analysis of Complex Carbohydrate Chains of Tissue Kallikreins" Adv.Exp.Med.Biol.247A. 533-538 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hiroo Terashima: "Characterization of Human Pancreatic Kallikrein" Adv.Exp.Med.Biol.247B. 177-182 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kazuyuki Kizuki: "Enzyme-Linked Immunosorbent Assays for Human Tissue Kallikrein and Analysis of Immunoreactive Kallikrein in The Plasma by Them" Adv.Exp.Med.Biol.247B. 211-216 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 鎌田雅史: "組織性カリクレイン微小多様性成分の特異的高感度検出法の開発" 生物物理化学. 33. 7-11 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Masafumi Kamada: "Observation of Tissue Prokallikrein Activation by Some Serine Proteases,Arginine Esterases in Rat Submandibular Gland" Biochem.Biophys.Res.Comm.166. 231-237 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Masafumi Kamada: "Generation of a Different Type of β-kallikrein from Porcine Pancreatic α-kallikrein by the Action of Chymotrypsin-Observation of Proteolytic Processing Occurring around‘Kallikrein Autolysis loop'Region" Chem.Pharm.Bull.38. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Masahiko Ikekita: "Human Urinary Kallikrein. II. Analysis of Asparagine-Linked Oligosaccharides by Using Lectins" Chem. Pharm. Bull.35. 2071-2078 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takuji Masunaga: "Observation of The Varied Micro-Heterogeneous Forms of Human Urinary Kallikrein Individual Excreted in Some Diseases" Jap. J. Clin. Chem.16. 8-17 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Satoru Suzuki: "Tissue Kallikrein in Human Plasma" Jap. J. Clin. Chem.16. 194-201 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hiroo Terashima: "Isolation and Characterization of Human Pancreatic Kallikrein" Nihon Shokakibyogakkai Zasshi. 85. 1320 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Masafumi Kamada: "Generation of Alpha- and Beta-Kallikreins from Porcine Pancreatic Prokallikrein by The Action of Trypsin" Chem. Pharm. Bull.36. 4891-4899 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Masahiko Ikekita: "Characterization of N-linked Oligosaccharides of Human Urinary Kallikrein Molecules" Adv. Exp. Med. Biol.247B. 157-162 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Charles C. Sweeley: "Fast Atom Bomberdment Mass Spectrometry (FAB-MS) : Analysis of Complex Carbohydrate Chains of Tissue Kallikreins" Adv. Exp. Med. Biol.247A. 533-538 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hiroo Terashima: "Characterization of Human Pancreatic Kallikrein" Adv. Exp. Med. Biol.247B. 177-182 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kazuyuki Kizuki: "Enzyme-Linked Immunosorbent Assays for Human Tissue Kallikrein and Analysis of Immunoreactive Kallikrein in The Plasma by Them" Adv. Exp. Med. Biol.247B. 211-216 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Masafumi Kamada: "Deveropment of A High Sensitive Method for Specific Detection of Micro-Heterogeneous Components of Tissue Kallikrein" Physico-Chem. Biol.33. 7-11 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Masafumi Kamada: "Observation of Tissue Prokallikrein Activation by Some Serine Proteases, Arginine Esterases in Rat Submandibular Gland" Biochem. Biophys. Res. Comm.166. 231-237 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Masafumi Kamada: "Genaration of A Different Type of Beta-Kallikrein from Porcine Pancreatic Alpha-Kallikrein by The Action Chymotypsin" Chem. Pharm. Bull.38. (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Histochemistry. 80巻4号・5号. (1984)

    • Related Report
      1987 Final Research Report Summary
  • [Publications] Chem.Pharm.Bull.32巻9号. (1984)

    • Related Report
      1987 Final Research Report Summary
  • [Publications] Chem.Pharm.Bull.34巻10号. (1986)

    • Related Report
      1987 Final Research Report Summary
  • [Publications] Adv.Exptl.Med.Biol.198巻A. (1986)

    • Related Report
      1987 Final Research Report Summary
  • [Publications] 臨床化学. 15巻4号. (1986)

    • Related Report
      1987 Final Research Report Summary
  • [Publications] Biomedical Sciences. 6巻1号. (1986)

    • Related Report
      1987 Final Research Report Summary
  • [Publications] 日本炎症学会雑誌. 6巻3号. (1986)

    • Related Report
      1987 Final Research Report Summary
  • [Publications] 臨床検査. 31巻1号. (1987)

    • Related Report
      1987 Final Research Report Summary
  • [Publications] Chem.Pharm.Bull.35巻5号. (1987)

    • Related Report
      1987 Final Research Report Summary
  • [Publications] 日本炎症学会雑誌. 7巻4号. (1987)

    • Related Report
      1987 Final Research Report Summary
  • [Publications] 臨床化学. 16巻1号. (1987)

    • Related Report
      1987 Final Research Report Summary

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Published: 1987-04-01   Modified: 2016-04-21  

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