| Project/Area Number |
62304009
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
動物発生・生理学
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| Research Institution | Nagoya University |
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Principal Investigator |
OHNISHI Eiji Faculty of Science, Nagoya University, 理学部, 教授 (60022521)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Okitsugu Faculty of Agriculture, Nagoya University, 農学部, 助教授 (50023411)
TAKAHASHI Y.Susumu Faculty of General Education, Yamaguchi University, 教養部, 教授 (90022665)
TOMINO Shiro Faculty of Science, Tokyo Metropolitan University, 理学部, 教授 (30101075)
NATORI Shunji Faculty of Pharmacology, University of Tokyo, 薬学部, 教授 (50012662)
CHINO Haruo Institute of Low Temperature, Hokkaido University, 低温科学研究所, 教授 (00012253)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 1988: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1987: ¥4,000,000 (Direct Cost: ¥4,000,000)
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| Keywords | Insects / Post-embryonic Development / Metabolic Control / 転字後修飾 / 後記発生 / 転写後修飾 |
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| Research Abstract |
In post-embryonic development of insects, drastic changes in metabolism could be found. Mechanisms of phenoloxidase activation have been analyzed in relation to cuticulogenesis and to defense mechanism. Ashida analyzed cascade system, involving several proteases, of pro-phenoloxidase of bombyx hemoymph. Yamazaki studied laccase-type oxidase in newly ecdysed cuticles. Ohnishi analyzed structure of the fragment released the prophenoloxidase upon activation. Natori has worked on defense system of the fleshfly, Sarcophage, and analyzed control mechanism of biosynthesis of 2 kinds of peptides, which are inducible by injury. Using affinity chromatography of chitin, Tomino isolated several cuticle-specific proteins and studied temporal pattern of expression of these proteins. Chino studied lipophorin system of locust as modified by adipokinetic hormone. Takahashi isolated cGMP-dependent protein kinase from Bombyx. Yamashita studied egg-specific protein and its protease of Bombyx eggs. Kageyama isolated new type of thiolprotease from Bombyx eggs. These studies revealed various phases of metabolic control mechanisms of insects and the mechanisms were analyzed at a molecular level.
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