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Comprehensive studies on transformation and dynamic nature of neoplastic cells in bovine leukemia

Research Project

Project/Area Number 62304028
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 基礎獣医学
Research InstitutionIwate University

Principal Investigator

OHSHIMA Kan-ichi  Fac. Agric., Iwate Univ., Prof., 農学部, 教授 (20003733)

Co-Investigator(Kenkyū-buntansha) SEKIKAWA Kenji  Natl. Inst. Animal Hlth., Laboratry Head, 生物物理研究室, 室長
OKI Yoshio  Nippon Veterinary and Zootechnical College, Prof., 獣医畜産学部, 教授 (30120760)
KOYAMA Hiroyuki  Kitasato Univ., Prof., 獣医畜産学部, 教授 (00072372)
YOSHIKAWA Takashi  Kitasato Univ., Prof., 獣医畜産学部, 教授 (80050467)
ONUMA Misao  Rakuno Gakuen Univ., Associate Prof., 酪農学部, 助教授 (70109510)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 1988: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1987: ¥6,000,000 (Direct Cost: ¥6,000,000)
KeywordsBovine leukosis / Bovine leukemia virus / in situ hybridization / Leukemic cell / env gene / Monoclonal antibody / pX gene / pX遺伝子 / env遺伝子 / 細胞質内ハイブリダイゼーション / 牛白血病細胞 / pX領域 / 糖鎖抗原 / ウイルス遺伝子
Research Abstract

1. The Japanese Lymphoma Study Group(LSG) classification was applied to bovine leukosis(BL) (182 enzootic BL; EBL, 12 calf type; CBL, 7 thymic type), and concluded it was appricable to BL. Most of the EBL were B-lymphocyte derived and another types were T-lumphocyte derived.
2. Monoclonal antibody c143 against specific tumor-associated antigen.(TAA) was found to be a useful tool not only for diagnosis of EBL but for screening of subclinical cattle with potential to develop tumors in the future.
3. Nine cell lines in vitro were established from peripheral leukemic cells with EBL. All were immature cell type, producing BL virus(BLV), having TAA, but some pocessed SIg. 5 monoclonal antibodies were prepared against the cell lines.
4. Proviral RNA have cloned. We found the envelopglycoprotein expression on cell surface induced membrane fusion is necessary for infectivity of BLV and PX region is necessary for viral replication. The PX-I and -II genes are transacting genes activating the viral gene expression.
5. For detection of messenger viral RNA, proviral DNA probes biotinylated were used for in situ hybridization in BLV producing Bat 2 cells. Positive results were obtained and the established technique maybe useful for dynamics of BLV in the living bodies.
6. An abnormal antigen in T-lymphoid tumor cell line derived from CBL was not detected in EBL. Sporadic bovine leukosis may be caused by diffrernt pathogene from the EBL.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (126 results)

All Other

All Publications (126 results)

  • [Publications] Onuma,M.et al.: Microbiol.Immunol.31. 131-137 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Onuma,M.et al.: Jpn.J.Vet.Sci.49. 137-140 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Aida,Y; Onuma,M.el al.: Archiv.Virol.94. 315-321 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Aida,Y; Onuma,M.el al.: Am.J.Vet.Res.48. 1181-1186 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Aida,Y; Onuma,M.el al.: Am.J.Vet.Res.48. 1319-1324 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tsukiyama,K; Onuma,M.et al.: Archiv.Virol.96. 89-96 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Odawara,T; Onuma,M; Yoshikawa,T.et al.: Jpn.J.Vet.Sci.49. 657-661 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ogawa,Y; Koyama,H; Onuma,M.et al.: Microbiol.Immunol.31. 1009-1015 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nishi,H; Onuma,M.et al.: Jpn.J.Vet.Sci.49. 909-912 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yasutomi,Y; Onuma,M.et al.: Jpn.J.Vet.Sci.49. 957-963 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ochiai,K; Onuma,M.et al.: Jpn.J.Vet.Sci.49. 1065-1072 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Onuma,M; Yoshikawa,T; Okada,K.et al.: Jpn.J.Cancer Res.(Gann). 79. 275-281 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Watarai,S; Onuma,M.et al.: Jpn.J.Vet.Sci.50. 463-469 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Maruyama,K; Onuma,M.et al.: Leukemia. 2. 216s-222s (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tsukiyama,K; Onuma,M.et al.: Jpn.J.Vet.Sci.50. 746-753 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Onuma,M.et al.: Vaccine. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Onuma,M.et al.: J.Vet.Med.(1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Onuma,M.et al.: Vet.Immunol.Immunopathol.(1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Onuma,M.et al.: Vet.Immunol.Immunopathol.(1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Koyama,H; Yoshikawa,T.et al.: J.Vet.Med.B. 34. 371-379 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yoshikawa,T.et al.: Jpn.J.Vet.Sci.(1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Koyama,H; Yoshikawa,T.et al.: J.Vet.Med.B. 33. 586-596 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kunita,S; Koyama,H.et al.: Vet.Immunopathol.18. 201-212 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Koyama,H.et al.: J.Vet.Med.B. 35. 648-653 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Koyama,H; Yoshikawa,T; Okada,K.et al.: Am.J.Vet.Res.(1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Itohara,D; Sekikawa,K.et al.: Leukemia Res.11. 407-414 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Itohara,S; Seki-kawa,K.: Virology. 159. 158-160 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Itohara,S; Sekikawa,K.et al.: J.Gen.Virol.69. 797-804 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Okada,K; Ohsima,K.et al.: Jpn.J.Vet.Sci.49. 373-377 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ohshima,K; Okada,K.et al.: Jpn.J.Vet.Sci.50. 1074-1078 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Okada,K; Ohsihma,K; Koyama,H.et.al.: Vet.Pathol.(1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 大島 他: 畜試研究報告. 47. 15-22 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 金谷、大木 他: 日獣大研究報告. 36. 1-7 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 柴藤、大木 他: 日獣大研究報告. 37. 5-9 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 関川、糸原: 研究ジャーナル. 10. 4-11 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 小沼: 家畜の研究. 42. 1065-1072 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Onuma,M.: "Transforming Activity of Bovine Leukemia Virus and Properties of Tumor-Associated Antigen on Bovine Lymphosarcoma." Martinus Nijhoff Publishing, 141-151 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Onuma, M., et al.: "Detection of cross-reactive antibody to BLV p24 in sera of human patients infected with HTLV." Microbiol. Immunol.31. 131-137 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Onuma, M., et al.: "Establishment of a lymphoid cell line from tumor of skin leukosis." Jpn. J. Vet. Sci.49. 137-140 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Aida, Y.,; Onuma, M., et al.: "Monoclonal antibodies define antigenic regions on major internal protein p24 of bovine leukemia virus(BLV)." Archiv. Virol.94. 315-321 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Aida, Y.,; Onuma, M., et al.: "Radiolocalization of bovine lymphosarcoma cells in athymic mice, using a monoclonal antibody against tumor-associated antigens." Am. J. Vet. Res.48. 1181-1186 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Aida, Y.,; Onuma, M., et al.: "Use of a viable-cell enzyme-linked immunosorbent assay(ELISA) for detection of monoclonal antibodies recognizing tumor-associated antigens on bovine lymphosarcoma cells." Am. J. Vet. Res.48. 1319-1324 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tsukiyama, K.,; Onuma, M., et al.: "Effect of platelet-derived factor on expression of bovine leukemia virus genome." Archiv. Virol.96. 89-96 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Odawara, T.,; Onuma, M.,; Yoshikawa, T., et al.: "Circulating immune domplex levels in cows with enzootic bovine leukosis." Jpn. J. Vet. Sci.49. 657-661 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ogawa, Y.,; Koyama, H.,; Onuma, M., et al.: "Structure of defective provirus of bovine leukemia virus." Microbiol. Immunol.31. 1009-1015 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nishi, H.,; Onuma, M., et al.: "Monoclonal antibodies against bovine skin leukosis cells." Jpn. J. Vet. Sci.49. 909-912 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yasutomi, Y.,; Onuma, M., et al.: "Early diagnosis of enzootic bovine leukosis." Jpn. J. Vet. Sci.49. 957-963 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ochiai, K.,; Onuma, M., et al.: "Suppressive effect on tumor growth of enzootic bovine leukemia cells in nude mice by monoclonal antibodies against tumor-associated antigens." Jpn. J. Vet. Sci.49. 1065-1072 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Onuma, M.,; Yoshikawa, T.,; Okada, K., et al.: "The screening of cattle with potential for developing leukemia by monoclonal antibody against bovine leukemia cells." Jpn. J. Cancer Res. (Gann). 79. 275-281 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Watarai, S.,; Onuma, M., et al.: "Reacting of antibody to ganglioside GD_3 against enzootic bovine lymphosarcoma tumor cells." Jpn. J. Vet. Sci.50. 463-469 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Maruyama, K.,; Onuma, M., et al.: "Elicitation of bovine antibody to BLV-gp51 by BLV-vacciation." Leukemia. 2. 216-222 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tsukiyama, K.,; Onuma, M., et al.: "Mitogenic activity of bovine platelet-derived factor on bovine leukemia virus-infected lymphocytes." Jpn. J. Vet. Sci.50. 746-753 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Onuma, M., et al.: "Regression of bovine lymphosarcoma by treatment with cell wall skeleton of Nocardia rubra(N-CWS)." Vaccine. In press. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Onuma, M., et al.: "Antitumor effect of adriamycine entrapped in liposomes conjugated with anti-bovine tumor antigen monoclonal antibody in leukemic dows." J. Vet. Med.In press. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Onuma, M.: "Tumor-associated antigen on bovine leukemia virus induced bovine lymphosarcoma." Vet. Immunol. Immunopathol.In press. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Onuma, M., et al.: "Chemotherapy and Immunotherapy of bovine leukosis." Vet. Immunol. Immunopathol.In press. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Koyama, H.,; Yoshikawa, T., et al.: "Frequency of lymphocytes bearing surface membrane immunoglobulin in leukemic cattle." J. Vet. Med. B. 34. 371-379 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yoshikawa, T., et al.: "Attempt for a cytological cytoimmunological classification of bovine leukosis." Jpn. J. Vet. Sci.In press. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Koyama, H.,; Yoshikawa, T., et al.: "Establishment of a continuous cell line derived from leukemic cattle." J. Vet. Med. B. 33. 586-596 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kunita, S.,; Koyama, H., et al.: "Preparation and characterization of monoclonal antibodies against bovine B lymphocyte surface antigens." Vet. Immunol. Immunopathol.18. 201-212 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Koyama, H., et al.: "Determination of lymphocyte count necessary for isolating bovine leukemia virus(BLV) from BLV-infected cattle and correlation between lymphocyte count and antibody titer." J. Vet. Med. B. 35. 648-653 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Koyama, H.,; Yoshikawa, T.,; Okada, K., et al.: "Establishment of continuous cell line derived from leukemic cattle." Am. J. Vet. Res.In press. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Itohara, D.,; Sekikawa, K., et al.: "Establishment of bovine leukemia virus-producing and -nonproducing B lymphoid cell lines and their proviral genomes." Leukemia Res.11. 407-414 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Itohara, S.; Sekikawa, K.: "Molecular cloning of infectious proviral genomes of bovine leukemia virus." Virology. 159. 158-160 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Itohara, S.,; Sekikawa, K., et al.: "Cooperative regulation of bovine leukemia virus gene expression by two over lapping reading frames in the XBL region." J. Gen. Virol.69. 797-804 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Okada, K.,; Ohshima, K., et al.: "Existence of antigens cross-linking to tumor associated antigens of enzootic bovine leukosis in normal tissues of bovine fetus." Jpn. J. Vet. Sci.49. 373-377 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ohshima, K.,; Okada, K., et al.: "An eradication program without economic loss in a herd infected with bovine leukemia virus(BLV)." Jpn. J. Vet. Sci.50. 1074-1078 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Okada, K.,; Ohshima, K.,; Koyama, H., et al.: "Spontaneous regression of bovine skin leukosis." Vet. Pathol.In press. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ohshima, K., et al.: "Chromosomal studies in bovine lymphosarcoma." Bull. Natl. Inst. Animal Industry. (47). 15-22 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kanaya, K.,; Oki, Y., et al.: "Experimental transmission to calf and proliferation in the peripheral blood lymphocyte of the virus associated with the cultured lymphoid tumor cell line from calf type of bovine leukosis." Bull. Nippon Vet. Zootechn. college. 36. 1-7 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shibato, T.,; Oki, Y., et al.: "Isolation and determination of cell membrane protein antigen from cultured lymphoid tumor cells from calf type of bovine leukosis." Bull. Nippon Vet. Zootechn. College. 37. 5-9 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Onuma, M.: Transforming activity of bovine leukemia virus and properties of tumor-associated antigen on bovine lymphosarcoma.Martinus Nijhoff Publishing, 141-151 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Onuma,M.,et al.: Microbiol.Immunol.31. 131-137 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Onuma,M.,et al.: Jpn.J.Vet.Sci.49. 137-140 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Aida,Y.,;Onuma,M.;et al.: Archiv.Virol.94. 315-321 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Aida,Y.,;Onuma,M.,et al.: Am.J.Vet.Res.48. 1181-1186 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Aida,Y.,;Onuma,M.,et al.: Am.J.Vet.Res.48. 1319-1324 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Tsukiyama,K.;Onuma,M.,et al: Archiv.Virol.96. 89-96 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Odawara,T.;Onuma,M.;Yoshikawa,T.,et al.: Jpn.J.Vet.Sci.49. 657-661 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ogawa,Y.;Koyama,H.;Onuma,M.,et al.: Microbiol.Immunol.31. 1009-1015 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Nishi,H.:Onuma,M.et al.: Jpn.J.Vet.Sci.49. 909-912 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yasutomi,Y.;Onuma,M.,et al.: Jpn.J.Vet.Sci.49. 957-963 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ochiai,K.;Onuma,M.,et al.: Jpn.J.Vet.Sci.49. 1065-1072 (1987)

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  • [Publications] Onuma,M.;Yoshikawa,T;Okada,K.,et al.: Jpn.J.Cancer Res.(Gann). 79. 275-281 (1988)

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  • [Publications] Watarai,S.;Onuma,M.,et al.: Jpn.J.Vet.Sci.50. 463-469 (1988)

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  • [Publications] Maruyama,K.;Onuma,M.,et al.: Leukemia. 2. 216s-222s (1988)

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  • [Publications] Tsukiyama,K.;Onuma,M.,et al.: Jpn.J.Vet.Sci.50. 746-753 (1988)

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  • [Publications] Onuma,M.,et al.: Vaccine. (1989)

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  • [Publications] Onuma,M.,et al.: J.Vet.Med.(1989)

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  • [Publications] Onuma,M.: Vet.Immunol.Immunopathol.(1989)

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  • [Publications] Onuma,M.,et al.: Vet.Immunol.Immunopathol.(1989)

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  • [Publications] Koyama,H.:Yoshikawa,T.,et al.: J.Vet.Med.B. 34. 371-379 (1987)

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  • [Publications] Yoshikawa,T.,et al.: Jpn.J.Vet.Sci.(1989)

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  • [Publications] Koyama,H.;Yoshikawa,T.,et al.: J.Vet.Med.B. 33. 586-596 (1986)

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  • [Publications] Kunita,S.;Koyama,H.,et al.: Vet.Immunol.Immunopathol.18. 201-212 (1988)

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  • [Publications] Koyama,H.,et al.: J.Vet.Med.B. 35. 648-653 (1988)

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  • [Publications] Koyama,H.;Yoshikawa,T.;Okada,K.et al.: Am.J.Vet.Res.In press. (1989)

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  • [Publications] Itohara,D.;Sekikawa,K.,et al.: Leukemia Res.11. 407-414 (1987)

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  • [Publications] Itohara,S.;Sekikawa,K.: Virology. 159. 158-160 (1987)

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  • [Publications] Itohara,S.;Sekikawa,K.,et al: J.Gen.Virol.69. 797-804 (1988)

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  • [Publications] Okada,K.;Ohshima,K.,et al.: Jpn.J.Vet.Sci.49. 373-377 (1987)

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  • [Publications] Ohshima,K.;Okada,K.,et al.: Jpn.J.Vet.Sci.50. 1074-1078 (1988)

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  • [Publications] Okada,K.;Ohshima,K.;Koyama,H.,et al.: Vet.Pathol.(1989)

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  • [Publications] 大島他: 畜試研究報告. 47. 15-22 (1988)

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  • [Publications] 金谷,大木 他: 日獣大研究報告. 36. 1-7 (1987)

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  • [Publications] 柴藤,大木 他: 日獣大研究報告. 37. 5-9 (1988)

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  • [Publications] 小沼: 畜産の研究. 42. 1065-1072 (1988)

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  • [Publications] Onuma,M.: "Transforming Activity of Bovine Leukemia Virus and Properties of Tumor-Associated Antigen on Bovine Lymphosarcoma." Martinus Nijhoff Publishing, 141-151 (1987)

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  • [Publications] Onuma,M. et al.: Jpn.J.Vet.Sci.49(1). 137-140 (1987)

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  • [Publications] Onuma,M. et al.: Microbiol.Immunol.31(2). 131-137 (1987)

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  • [Publications] Aida,Y. et al.: Am.J.Vet.Res.48(9). 1319-1324 (1987)

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  • [Publications] Ochiai,K. et al.: Jpn.J.Vet.Sci.49(6). 1065-1072 (1987)

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  • [Publications] Koyama,H.et al.: J.Vet.Med.,B. 34. 371-379 (1987)

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  • [Publications] Itohara,S.et al.: Leukemia Res.11. 407-414 (1987)

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  • [Publications] Itohara,S.et al.: Virology. 159. 158-160 (1987)

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  • [Publications] Itohara,S.et al.: J.Gen.Virol.(1988)

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  • [Publications] Yoshikawa,T.et al.: Jpn.J.Vet.Sci.(1988)

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  • [Publications] 関川賢二 他: 研究ジャーナル. 10. 4-11 (1987)

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  • [Publications] Okada,K.et al.: Jpn.J.Vet.Sci.49. 373-377 (1987)

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  • [Publications] Suzuki,M.et al.: Jpn.J.Vet.Sci.49. 841-846 (1987)

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  • [Publications] 金谷和明 他: 日獣大研報. 36. 1-7 (1987)

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  • [Publications] 大島寛一: 養牛の友. 134号. 6-12 (1988)

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  • [Publications] Onuma,M.: "Enzootic Bovine Leukosis and Bovine Leukemia Virus" Martinus Nijhoff Publishing, 283 (1987)

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Published: 1987-04-01   Modified: 2016-04-21  

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