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Neuronal and chemical control of emotical behavior

Research Project

Project/Area Number 62304031
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research InstitutionKyushu University

Principal Investigator

OOMURA Yutaka  Kyushu University, Med. Honorary Professor, 医学部, 名誉教授 (30019517)

Co-Investigator(Kenkyū-buntansha) ONODA Norihiko  Gunma University, Med. Associate Professor, 医学部, 助教授 (60106903)
HORI Tetsurou  Saga Medical College, Professor, 医学部, 教授 (00022814)
ONO Taketoshi  Toyama Medical and Pharmacological University, Med. Professor, 医学部, 教授 (50019577)
YAMASHITA Hiroshi  University of Occupational and Environmental Health, Professor, 教授 (00030841)
NIIJIMA Akira  Niigata University, Med. Professor, 医学部, 名誉教授 (20018287)
Project Period (FY) 1987 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥9,100,000 (Direct Cost: ¥9,100,000)
Fiscal Year 1989: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1988: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1987: ¥3,000,000 (Direct Cost: ¥3,000,000)
Keywordschemosensitive neuron / direction-related neuron / neural transplantation / olfactory receptor neuron / hypothalamic thermosensitive neuron / autonomic nerve / acidic fibroblast growth factor / hypothalamic neuronal histamine / 海馬学習関連ニュ-ロン / 視床下部温度ニュ-ロン / 肝門脈IL-1βセンサ- / 化学感受性ニューロン / 海馬方向選択ニューロン / 脳Na利尿ホルモン / セロトニンEC細胞 / 脳移植 / 免疫サイトカイン / 不斉合成 / 情報行動 / 神経的制御 / 化学的制御 / ペプチド / 有機酸 / 本能行動 / 脳内移殖 / 体温調節
Research Abstract

To clarify the neuronal and chemical control mechanism of emotional behavior, it was investigated that functional roles of biologically active substairces in neuronal circuits which integrate external and internal informations. Oomura showed that acidic fibroblast growth factor (AFGF) which increased in the spinal fluid during and after feeding suppressed food intake through the chemosensitive neurons in the feeding center. The involvement of this substance in learning behavior and recovery of hippocampal cell damage in the brain ischemia was also investigated. Ono studied neuronal mechanism of emotions in the monkey amygdala and hippocampus, and found highly selective cognitive-related neurons in the amygdala and highly selective direction-related neurons in the hippocampus. Kawamura showed that fetal ventromedial hypothalamic (VMH) grafs into VMH lesioned rats resulted in reduced consumption of food, and demonstrated the presence of glucoreceptor neurons which were electrophysiologic … More ally identified in the VMH graft. Onoda studied immunohistochemical.staining patterns in the rabbit olfactory epithelium in adulthood, during development and after olfactory bulbectomy by using monoclonal antibodies against the rabbit olfactory bulb. Hori investigated the activity of hypothalamic thermosensitive neurons as toits temperature transductionmechanisms, the role in thermoregulatory behavior and the responsivenessto immune cytokines and therelated peptides. Yamashita examined chemosensitivity of neurons in the periventricular organs and hypothalamus involved in control of body water balance using rat brain slice preparations. Kiijima showed that intravenous administration of 2-B40 and IL-1beta increased, and that of ANP decreased efferent,activity of the sympathetic nerves innervating visceral organs. He also observed the effects of these substance on sensory afferent nerve activity from the portal vein.. Nakagawa examined mechanism of macronutrient selection in rats and found that the suprachiasmatic nucleus hadfunctions to increase protein intake through glucagon secretion and to decrease carbohydrate intake after applicating cholecystokinin into the VMH. Sakata clarified the involvement of hypothalamic histaminergic neuron in regulation of feeding behavior and body temperature. Kimura demonstrated immunohistochemical evidence for aFGF-like structures in the rat brain. Yanaihara produced region-specific antibodies against GLP-1 and AFGF which were valuable for physiological andimmunohistochemical studies. Sakai synthesized optically active 3-DPA and its delivatives by using asymmetric hydrolysis with pseudomonas fluorecens lipase. Less

Report

(4 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • Research Products

    (62 results)

All Other

All Publications (62 results)

  • [Publications] Thibault.L.: "Satietion due to CCK-8 derivative infusion into VMH is related to a special macronutrient selection." Phyisology and Behavior. in press. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Fukagawa,K.: "Neuronal histamine modulates feeding behavior through H_1-receptor in rat hypothalamus." Am.J.Physiol.256. R605-R611 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kimura,H.: "Fibronectin-like immunoreactive structures in embryonic rat brain." Acta Histochem.Cytochem.22. 243-258 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yanaihara,N.: "Recent advances in brain-gut hormones." Arch.Histol.Cytol.52. 49-54 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hizuka,M.: "A stereocontrolled synthesis of trisubstituted cyclohexanes and cyclopentanes.Its applocation to the synthesis of 11-deoxyprostaglandins." Chem.Pharm.Bull.37. 1185-1187 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Onoda,N.: "Monoclonal antibody immunohistochemistry of rabbit olfactory receptor neurons during development." Neuroscience. 26. 1003-1012 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hanai,K.: "Central action of acidic fibroblast growth factor(aFGF)on feeding regulation." Am.J.Physiol.256. R217-R223 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ono,T.: "Contribution of amygdalar and lateral hypothalamic neurons to visual information processing of food and nonfood in monkey." Physiol.and Behav.45. 411-421 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ono,K.: "Fetal hypothalamic brain grafts to the ventromedial hypoothalamic obese rats:an immunohistochemical,electrophysiological and behavioral study." Brain Res.Bull.24. (inpress.)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Nakashima,T.: "Recombinant human interleukin-1β alters the activity of preoptic thermosensitive neurons in vitro." Brain Res.Bull.23. 209-213 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamashita,H.: "Effect of brain-gut peptides upon neurons in centrally regulating sites for drinking." Arch.Histol.Cytol.Suppl.52. 127 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Niijima,A.: "The effect of rANP on the efferent activity of the autonomic nerves." Arch.Histol.Cystol.,Suppl.52. 325-329 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ono,T.: "The inferotemporal-amygdaloid-lateral hypothalamic axis in learning and emotion.In K.V.Sudakov(Ed.),Systems Reserch in Physiology,4" Gordon and Breach,Science Publishers,USSR,in press., inpress. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hori,T.: "Thermal Physiology(Ed.J.B.Mercer)" Elsevier Scientific Publ.B.V.,New York, 822 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Oomura,Y.: "Endogenous chemical sense in control of feeding." D.Ottoson,E.R.Perl,R.F.Schmidt,H.Shimizu and W.D.Willis, (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Oomura,Y.: "Role of central catecholaminergic and cholinergic systems in reward related responses in monkey cortex." K.V.Sudakov,Harwood Academic Publishers, (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Thibault, L.: "Satietion due to CCK-8 derivative infusion into VMH is related to a special macronutrient selection." Physiology and Behavior. (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Fukagawa, K.: "Neuronal histamine modulates feeding behavior through H_1-receptor in rat hypothalamus." Am. J. Physiol.256. 605-611 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kimura, H.: "Fibronectin-like immunoreactive structures in embryonic rat brain." Acta Histochem. Cytochem.22. 243-258 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yanaihara, N.: "Recent advances in brain-gut hormones." Arch. Histol. Cytol.52. 49-54 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hizuka, M.: "A stereocontrolled synthesis of trisubstituted cyclohexanes and cyclopentanes. Its application to the synthesis of 11-deoxyprostaglandins." Chem. Pharm. Bull.37. 1185-1187 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Onoda, N.: "Monoclonal antibody immunohistochemistry of rabbit olfactory receptor neurons during development." Neuroscience. 26. 1003-1012 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hanai, K.: "Central action of acidic fibroblast growth factor (aFGF) on feeding regulation." Am. J. Physiol.256. 217-223 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ono, T.: "Contribution of amygdalar and lateral hypothalamic neurons to visual information processing of food and nonfood in monkey." Physiol. and Behav.45. 411-421 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ono, K.: "Fetal hypothalamic brain grafts to the ventromedial hypothalamic obese rats: an immunohistochemical, electrophysiological and behavioral study." Brain Res. Bull.24.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Nakashima, T.: "Recombinant human interleukin-1beta alters the activity of preoptic thermosensitive neurons in vitro." Brain Res. Bull. 23. 209-213 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamashita, H.: "Effect of brain-gut peptides upon neurons in centrally regulating sites for drinking." Arch. Histol. Cystol.Suppl 52. 127 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Niijima, A.: "The effect of rANP on the efferent activity of the autonomic nerves." Arch. Histol. Cystol.Suppl 52. 325-329 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ono, T.: "The inferotemporalamygdaloid-lateral hypothalamic axis in learning and emotion." K.V. Sudakoc (Ed.), Systems Research in Physiology, 4. Gordon and Breach, Science publishers, USSR. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hori, T.: "Thermal Physiology" J.B. Mercer (Ed.), Elsevier Scientific Publ. B.V., New York, 822, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Oomura, Y.: "Endogenous chemical sense in control of feeding." D. Ottoson, E.R. Perl, R.F. Schmidt, H. Shimizu and W.D. Willis, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Oomura, Y.: "Role of central catecholaminergic and cholinergic systems in reward related responses in monkey cortex." K.V. Sudakov, Harwood Academic Publishers, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Thibault,L.: "Satietion due to CCK-8 derivative infusion into VMH is related to a special macronutrient selection." Phyisology and Behavior. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Sakata,T.: "Stereospecific feeding modualtion by endogenous organic acid γ-lactone in rats." Am.J.Physiol.256. R366-R370 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Fukagawa,K.: "Neuronal histamine modulated feeding behavior through H_1-receptor in rat hypothalamus." Am.J.Physiol.256. R605-R611 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kimura,H.: "Fibronectin-like immunoreactive structures in embryonic rat brain." Acta Histochem.Cytochem.22. 243-258 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Yanaihara,N.: "Recent advances in brain-gut hormones." Arch.Histol.Cytol.52. 49-54 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hizuka,M.: "A Stereocontrolled synthesis of trisubstituted cyclohexanes and cyclopentanes.Its application to the synthesis of 11-deoxyprostaglandins." Chem.Pharm.Bull.37. 1185-1187 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hanai,K.: "Central action of acidic fibroblast growth factor(aFGF)on feeding regulation." Am.J.Physiol.256. R217-R223 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ono,T.: "Contribution of amygdalar and lateral hypothalamic neurons to visual information processing of food and nonfood in monkey." Physiol.and Behav.45. 411-421 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ono,K.: "Fetal hypothalamic brain grafts to the ventromedial hypothalamic obese rats:an immunohistochemical,electrophysiological and behavioral study." Brain Res.Bull.24.

    • Related Report
      1989 Annual Research Report
  • [Publications] Nakashima,T.: "Recombinant human interleukin-1β alters the activity of preoptic thermosensitive neurons in vitro." Brain Res.Bull.23. 209-213 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Yamashita,H.: "Effect of brain-gut peptides upon neurons in centrally regulating sites for drinking." Arch.Histol.Cytol.,Suppl.52. 127- (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Niijima,A.: "The effect of rANP on the efferent activity of the autonomic nerves." Arch.Histol.Cystol.,Suppl.52. 325-329 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ono,T.: "The inferotemporal-amygdaloid-lateral hypothalamic axis in learning and emotion.In K.V.Sudakov(Ed.),Systems Reserch in Physiology,4" Gordon and Breach,Science Publishers,USSR,in press., (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hori,T.: "Thermal Physiology(Ed.J.B.Mercer)" Elsevier Scientific Publ.B.V.,New York, 822 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Oomura,Y.: "Endogenous chemical sense in control of feeding." D.Ottoson,E.R.Perl,R.F.Schmidt,H.Shimizu and W.D.Willis, (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Oomura,Y.: "Role of central catecholaminergic and cholinergic systems in reward related responses in monkey cortex." K,V.Sudakov,Harwood Academic Publishers, (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] H.Nishino.: Brain Res.Bull.20. 839-845 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] M.Fukuda.: J.Neurophysiol.57. 1060-1077 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] M.Fujimiya.: Neurosci.Res.

    • Related Report
      1988 Annual Research Report
  • [Publications] N.Onoda.: Neurosci.26. 993-1002 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Nakashima.: Brain Res.454. 361-367 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Nagai.: Life Sciences. 43. 1575-1582 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Ono.: "Cellular mechanisms of conditioning and behavioral plasticity." Plenum Press, 149-159 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] H.Yamashita.: "Recent progress in posterior pituitary hormones 1988" Elsevier Science Publishers B.V., 3-10 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yasuhiko Nakano: J.Neurophysiol.57. 72-91 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Hitoo Nishino: Brain Res.405. 56-67 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] M.Fukuda: J.Neurophysiol.57. 1060-1077 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Tetsuro Hori: Brain Res.Bull.18. 649-655 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] K.Nakamura: J.Neurophysiol.58. 1123-1148 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] K.Inenaga: Neurosci.Lett.79. 123-127 (1987)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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