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The research on repair of brain lesions including aging: In search of mechanisms responsible for maintaining the function of the remaining neurons

Research Project

Project/Area Number 62304040
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionNiigata University

Principal Investigator

IKUTA Fusahiro  Brain Research Institute, Niigata University, Department of Experimental Neuropathology, Director and Professor, 脳研究所, 教授 (20018592)

Co-Investigator(Kenkyū-buntansha) TOYOKURA Yasuo  Tokyo metropolitan Geriatric Hospital, Director, 院長, 東京大学名誉教授 (50009875)
IHARA Yasuo  Tokyo Metropolitan Institute of Gerontology, 2nd Laboratory of Clinical Physiolo, 臨床第2生理, 室長 (60114386)
MANNEN Toru  University of Tokyo, Faculty of Medicine, Department of Neurology, Professor, 医学部, 教授 (10010208)
NAGAI Yoshitaka  University of Tokyo, Faculty of Medicine, Department of Biochemistry, Professor, 医学部, 教授 (80072974)
TOMONAGA Masanori  University of Tokyo, Faculty of Medicine, Department of Neuropathology, Professo, 医学部, 教授 (10072977)
伊藤 正男  東京大学, 医学部, 教授 (90009887)
Project Period (FY) 1987 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 1989: ¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 1988: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1987: ¥5,900,000 (Direct Cost: ¥5,900,000)
KeywordsNeuronal degeneration / Brain lesion repair / Neuronal regeneration / Alzheimer's disease / Astrocyte / Bunina body / Large neurons / Ganglioside / Sprouting / GFAP / 神経細胞機能 / 機能修復
Research Abstract

The aim of this research is to elucidate the mechanisms of lesion repair in the neurodegenerative conditions, in which neurons degenerate, and eventually die and disappear in the brain, and is to search for the way to support or maintain the brain function. Our three-year plan for the project appeared to result in success.
Tomonaga demonstrated that Alzheimer's disease brain extract stimulated the survival of cerebral cortical neurons from neonatal rats; Alzheimer's brain extract contained 4-fold neurotrophic activity of normal brain extract. Subsequently, it was concluded that the neurotrophic action of Alzheimer's brain extract was due to the loss of inhibitory factors for survival and neurite formation of cerebral cortical neurons. Ihara disclosed that paired helical filaments observed in the Alzheimer's brain contained phosphorylated tau polypeptide as a major antigenic determinant. Using antibodies to human tau, he revealed massive somatodendritic sprouting of cortical neurons in A … More lzheimer's disease. This fact was further confirmed biochemically; MAP 5, a embryonal microtuble-associated protein, was bound to the paired helical filaments. Ikuta showed morphometrically that in Alzheimer's disease significant and selective decrease of large neurons occurred in the neostriatum, indicating that this nucleus was also exposed to the disease process. His ultrastructural study also suggested that Bunina bodies, characteristic cytoplasmic inclusions in the remaining lower motor neurons in motor neuron disease, might be derived from the endoplastic reticulum, being of great interest in considering the pathogenesis of motor neuron disease. Mannen studied the distribution of beta protein precursor in the Alzheimer's brain and showed that the amount of this protein did not increase in the disease. Kumanishi obtained a CDNA fragment of human GFAP. As the nucleotide sequence of this clone possessed 85.7% homology with that of the mouse GFAP, this clone was identified as one encoding human GFAP. Using the techniques of molecular biology, he is now studying the relationship of neuronal loss with astrocytosis in the human brain. Hirai examined the Alzheimer's brain immunohistochbmically using antibodies to amyloid beta protein and revealed widespread particular senile plaques in both cerebrum and cerebellum. Now, he is also studying the problem of neuronal cell death biochemically. Nagai found that a tetrasialoganglioside, GQlb, promoted neurite outgrowth when added in nanomolar concentrations to cells from two human neuroblastoma cell lines. Based on this finding, he subsequently discovered a new type of biosignal transduction that was mediated through cell surface carbohydrate recognition (ecto biosignal transduction system). Toyokura examined the aged and demented brains and revealed that there was apparent difference in the degree of neuronal loss in the lateral occipitotemporal gyrus between the two groups. Ito analyzed the mechanisms responsible for long-term depression in the cerebellum.
These results obtained by this research group must be important in further studies in the field of neuroscience dealing with the neurodegenerative conditions, including aging and Alzheimer's disease, and their lesion repair. Less

Report

(4 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report

Research Products

(189 results)

All Other

All Publications (189 results)

  • [Publications] 朝長正徳: "アルツハイマ-型老年痴呆" 藤田企画出版, 298 (1988)

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    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kameyama,Masakuni: "Cerebrovascular disease." IgakuーShoin, 184 (1988)

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  • [Publications] 萬年徹: "「疾患からみた神経回路網」筋萎縮性側索硬化症" 東京大学出版会, 45-57 (1988)

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      1989 Final Research Report Summary
  • [Publications] 豊倉康夫: "疾患からみた神経回路網" 東京大学出版会, 1-173 (1988)

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  • [Publications] Oyanagi K.: "Morphometric investigation on the neostriatum and spinal cord in extrapyramidal degenerative disease and amyotrophic lateral sclerosis." Brain Nerve (Tokyo). 40. 47-54 (1988)

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  • [Publications] Ohama E.: "Mitochondrial angiopathy in the cerebral blood vessels of MELAS." Brain Nerve (Tokyo), 40, 109-118, 1988.

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      1989 Final Research Report Summary
  • [Publications] Oyanagi K.: "Cytoarchitectonic investigation of the rat spinal cord following ethylnitrosourea administration at different developmental stages." Virchows Archiv A Pathol Anat Histopathol 412, 215-224, 1988.

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  • [Publications] Ohara S.: "An sutopsy case of MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and strokelike episode)." Clin Neurol, 28, 303-310, 1988.

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  • [Publications] Ohama E.: "Mitochondrial abnormalities in choroid plexus of Leigh disease." Brain Dev, 10, 30-35, 1988.

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  • [Publications] Takeda S.: "Neuropathology of myoclonus epilepsy associated with ragged-red fibers (Fukuhara's disease)." Acta Neuropathol, 75, 433-440, 1988.

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  • [Publications] Ohama E.: "A new type of cytoplasmic inclusion in human choroid plexus. A histochemical, ultrastructural and frequency study." Acta Neuropathol, 76, 11-16, 1988.

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  • [Publications] Ohara S.: "Schwann cell responses during regeneration after one or more crush injuries to myelinated nerve fibers." Neuropathol Appl Neurobiol, 14, 229-245, 1988.

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  • [Publications] Ohara S.: "Alterations of oligodendrocytes and demyelination in the spinal cord of patients with mitochondrial encephalomyopathy." J Neurol Sci, 86, 19-29, 1988.

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  • [Publications] Takahashi H.: "Hereditary dentatorubral-pallidoluysian atrophy:clinical and pathologic variants in a family." Neurology, 38, 1065-1070, 1988.

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      1989 Final Research Report Summary
  • [Publications] Oyanagi K.: "Selective decrease of large neurons in the neostriatum in progressive supranuclear palsy." Brain Res, 458, 218-223, 1988.

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      1989 Final Research Report Summary
  • [Publications] Wakabayashi K.: "Parkinson's disease: the presence of Lewy bodies in Auerbach's and Meissner's plexuses." Acta Neuropathol 76, 217-221, 1988.

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      1989 Final Research Report Summary
  • [Publications] Wakabayashi K.: "Tyrosine hydroxylase-immunoreactive intrinsic neurons in Auerbach's and Meissner's plexuses of humans." Neurosci Lett, 96, 259-263, 1989.

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  • [Publications] Oyanagi K.: "Evidence for sequential degeneration of the neurons in the intermediate zone of the spinal cord in amyotrophic lateral sclerosis: a topographic and quantitative investigation." Acta Neuropathol, 77, 343-349, 1989.

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  • [Publications] Ikuta F.: "Multiple sclerosis (MS)." Spine Spinal Cord, 2, 253-256, 1989.

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  • [Publications] Kawai K.: "Ultracytochemical study of capillary Ca^<2+>-ATPase activity in brain edema." Acta Neuropathol, 77, 449-454, 1989.

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      1989 Final Research Report Summary
  • [Publications] Oyanagi K.: "Amyotrophic lateral sclerosis." Spine Spinal Cord, 2, 335-338, 1989.

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      1989 Final Research Report Summary
  • [Publications] Takeda S.: "Adrenoleukodystrophy - Early ultrastructural changes in the brain." Acta Neuropathol, 78, 124-130, 1989.

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  • [Publications] Wakabayashi K.: "Occurrence of neurofibrillary tangles in the celiac ganglia." Acta Neuropathol, 78, 448, 1989.

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  • [Publications] Wakabayashi K.: "An autopsy case of senile dementia with numerous neocortical senile plaques and preserved subcortical nuclei." Clin Neurol, 29, 1163-1167, 1989.

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      1989 Final Research Report Summary
  • [Publications] Oyanagi K.: "Correlative decrease of large neurons in the neostriatum and basal nucleus of Meynert in Alzheimer's disease." Brain Res, 504, 354-357, 1989.

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  • [Publications] Wakabayashi K.: "Lewy bodies in the enteric nervous system in Parkinson's disease." Arch Histol Cytol, 52, Suppl., 191-194, 1989.

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      1989 Final Research Report Summary
  • [Publications] Takahashi H.: "Occurrence of 15-nm-wide straight tubules in neocortical neurons in progressive supranuclear palsy." Acta Neuropathol, 79, 233-239, 1989.

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      1989 Final Research Report Summary
  • [Publications] Tomonaga M.: "Changes of the neuronal size in the brain by aging and of Alzheimer's dementia" Brain Nerve (Tokyo), 40, 57-64, 1988.

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      1989 Final Research Report Summary
  • [Publications] Tomonaga M.: "Distribution of PHF immunoreactivity in the aged and demented brains." Dementia, 2, 71-76, 1988.

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  • [Publications] Ikeda K.: "Creatine kinase immunoreactivity: localization in nerve terminals in the hypothalamic area and superior colliculus of the mouse brain." Neurosci Lett, 85, 51-55, 1988.

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  • [Publications] Uchida Y.: "Alzheimer's disease brain extract stimulates the survival of cerebral cortical neurons from neonatal rats." Biocheim Biophys Res Commun, 150, 1263-1267, 1988.

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      1989 Final Research Report Summary
  • [Publications] Uchida Y.: "Neurotrophic action of Alzheimer's disease brain extract is due to the loss of inhibitory factors for survival and neurite formation of cerebral cortical neurons." Brain Res, 481, 190-193, 1989.

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  • [Publications] Namba Y.: "Senile plaques in Alzheimer's disease have protease nexin I immunoreactivity." J Clin Exp Med (IGAKU NO AYUMI), 151, 613-614, 1989.

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  • [Publications] Yamaguchi H.: "A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by beta protein immunostaining." Acta Neuropathol, 76, 541-549, 1988.

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  • [Publications] Yamaguchi H.: "Diffuse type of senile plaques in the brains of Alzheimer-type dementia." Acta Neuropathol, 77, 113-119, 1988.

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  • [Publications] Tanaka M.: "Effects of nerve growth factor and gangliosides on neurite elongation of cultured nerve cells from senescent mouse" Jpn J Geriat 26, 563-570, 1989.

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  • [Publications] Kuzuhara S.: "Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study." Acta Neuropathol, 75, 345-353, 1988.

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  • [Publications] Ishiguro K.: "A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau." J Biochem, 104, 319-321, 1988.

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      1989 Final Research Report Summary
  • [Publications] Ihara Y.: "Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease." Brain Res, 459, 138-144, 1988.

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  • [Publications] Kondo J.: "The carboxyl third of tau is tightly bound to paired helical filaments." Neuron, 1, 827-834, 1988.

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  • [Publications] Mori H.: "A distinct form of tau is selectively incorporated into Alzheimer's paired helical filaments." Biochem Biophys Res Commun, 159, 1221-1226, 1989.

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  • [Publications] Takio K.: "Identification of beta protein precursor in newborn rat brain." Biochem Biophys Res Commun, 160, 1296-1301, 1989.

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  • [Publications] Ihara Y.: "Polypeptide composition of paired helical filaments." Ann Med, 21, 121-125, 1989.

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  • [Publications] Ihara Y.: "What mediates between beta-amyloid and paired helical filaments?" Neurobiol Aging, 10, 573-574, 1989.

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  • [Publications] Onda K.: "Correlation of DNA ploidy and morphological features of human glioma cell cultures with the establishment of cell lines." Acta Neuropathol, 76, 433-440, 1989.

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  • [Publications] Nishiyama A.: "Isolation of a cDNA to human GFAP and a study on GFAP expression in human glioma cell lines." Brain Tumor Pathol, 6, 125-131, 1989.

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  • [Publications] Nishiyama A.: "Differential expression of glial fibrillary acidic protein in human glioma cell lines." Acta Neuropathol, 78, 9-15, 1989.

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  • [Publications] Kumanishi T.: "Primary malignant lymphoma of the brain: demonstration of immunoglobulin gene rearrangements in four cases by the Southern blot hybridization technique." Acta Neuropathol, 79, 23-26, 1989.

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  • [Publications] Tsuji S.: "A novel, carbohydrate signal-mediated cell surface protein phosphorylation: ganglioside GQlb stimulates ectoprotein kinase activity on the cell surface of a human neuroblastoma cell line, GOTO." J Biochem, 104, 498-503, 1988.

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  • [Publications] Tsuji S.: "Synthetic sialyl compounds as well as natural gangliosides induce neuritogenesis in a mouse neuroblastoma cell line (Neuro2a)." J Neurochem, 50, 414-423, 1988.

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  • [Publications] Akashi M.: "Neutral and sialosyl glycosphingolipid composition and metabolism of human T-lymphoblastic cell line MOLT-3 cells: distinctive changes as markers specific for their differentiation." Blood, 72, 469-479, 1988.

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  • [Publications] Nagai Y.: "Bioactive ganglioside-mediated carbohydrate recognition in coupling with ecto-protein phosphorylation." 1989 Carbohydrate recognition in cellular function. Wiley, Chichester (Ciba Foundation Symposium 145), pp119-134.

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  • [Publications] Itonori S.: "Involvement of the acyl chain of ceramide in carbohydrate recognition by an anti-glycolipid monoclonal antibody: the case of an anti-melanoma antibody, M2590, to G_<m3>-ganglioside." Glycoconjugate J, 6, 551-560, 1989.

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  • [Publications] Ito J.: "Induction of astroglial growth inhibition and differentiation by sialosyl cholesterol." Brain Res, 481, 335-343, 1989.

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  • [Publications] Kusunoki S.: "Discrimination of human dorsal root ganglion cells by anti-fucosyl GMl antibody." Brain Res, 494, 391-395, 1989.

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  • [Publications] Kusunoki S.: "Motor dominant neuropathy and IgM paraproteinemia: the IgM M-protein binds to specific gangliosides." J Neuroimmunol, 21, 177-181, 1989.

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  • [Publications] Matsumura K.: "The immunological homology between two filamentous cross-linker phosphoproteins, connection and cross-bridge region of neurofilament-H, is not affected by the phosphorylation state." J Biochem, 105, 226-230, 1989.

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  • [Publications] Ono S.: "Intracytoplasmic inclusion bodies of the thalamus and the substantia nigra, and Marinesco bodies in myotonic dystrophy: a quantitative morphological study." Acta Neuropathol, 77, 350-356, 1989.

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  • [Publications] Ito M.: "Long-term depression." Ann Rev Neurosci, 12, 85-102, 1989.

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  • [Publications] Ito M.: "Long-term desensitization of quisqualate-specific gultamate receptors in Purkinje cells investigated with wedge recording from rat cerebellar slices." Neurosci Res, 7, 168-171, 1989.

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  • [Publications] Ono S.: "Increased dermal collagen density in amyotrophic lateral sclerosis." J Neurol Sci, 83, 81-92, 1988.

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  • [Publications] Ono S.: ""Delayed return phenomenon" in amyotrophic lateral sclerosis." Acta Neurol Scand, 77, 102-107, 1988.

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  • [Publications] Kuzuhara S.: "Clinical features of diffuse Lewy body disease. Report of 8 cases and review of the literature." Clin Neurol, 28, 1274-1281, 1988.

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  • [Publications] Yamanouchi H.: "The nucleus basalis of Meynert in progressive subcortical vascular encephalopathy of Binswanger's type in the elderly." Neurol Med (Tokyo), 28, 77-79, 1988.

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  • [Publications] Ikuta F.: "Brain edema and brain death." Iwate Iho, 447, 101-117, 1988.

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  • [Publications] Wakabayashi K.: "Pathology of Parkinson's disease." Chiryogaku, 22, 255-258, 1989.

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  • [Publications] Nagai Y.: "Gangliosides in recongnitive cell interactions and carbohydrate-mediated biosignalling." Lectins and Glycoconjugates in Oncology (Eds. Hans J Gabius, Gred A Nagel), Springer-Verlag, 59-66, 1988.

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  • [Publications] Nagai Y.: "Cell biological significance of gangliosides in neural differentiation and development: Critique and proposals." Fidia Research Series (New trends in ganglioside research. Eds RW Ledeen, EL Hogan, G Tettamanti, AJ Yates & RKYu Springer Verlag), 14:329-350, 1988.

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  • [Publications] Nagai Y.: "The roles of gangliosides in carbohydrate recognition and signal transduction (novel, ganglioside-dependent ecto protein phosphyrylation)." J Neurochem, 52:S4, 1989.

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  • [Publications] Tsuji S.: "Analysis of ecto-protein kinase activities on the cell surface of several neuronal and glia-like cell lines." J Neurochem, 52:S186, 1989.

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  • [Publications] Ito M.: "Molecular mechanisms of long-term depression in the cerebellum." Brain Signal Transduction and Memory (eds: Ito M & Nishizuka Y), 12:199-212, 1989.

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  • [Publications] Kanemaru K.: "The marfan syndrome with an XYY chromosome pattern." Jpn J Med, 27:74-78, 1988.

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  • [Publications] Tomonaga M.: "Senile dementia of Alzheimer type." Fujita-Kikaku, 298pp, 1988.

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    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kameyama M.: "Cerebrovascular disease." Igaku-shoin, 184pp, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Wakabayashi,Koichi: "Tyrosine hydroxylase-immunoreactive intrisic neurons in Auerbach´s and Meissner´s Plexuses of humans." Neurosci Lett. 96. 259-263 (1989)

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      1989 Annual Research Report
  • [Publications] Oyanagi,Kiyomitsu: "Evidence for sequential degeneration of the neurons in the intermediate zone of the spinal cord in amyotrophic lateral sclerosis:a topographic and quantitative investigation." Acta Neuropathol. 77. 343-349 (1989)

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      1989 Annual Research Report
  • [Publications] 若林孝一: "パ-キンソン病の病理形態学" 治療学. 22. 255-258 (1989)

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  • [Publications] 生田房弘: "多発性硬化症(MS)" 脊椎脊髄. 2. 253-256 (1989)

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      1989 Annual Research Report
  • [Publications] Kawai,Kensuke: "Ultracytochemical study of capillary Ca^<2+>ーATPase activity in brain edema." Acta Neuropathol. 77. 449-454 (1989)

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      1989 Annual Research Report
  • [Publications] 小柳清光: "筋萎縮性側索硬化症(ALS)" 脊椎脊髄. 2. 335-338 (1989)

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      1989 Annual Research Report
  • [Publications] Takeda,Shigeki: "Adrenoleukodystrophy-Early ultrastructural changes in the brain." Acta Neuropathol. 78. 124-130 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Wakabayashi,Koichi: "Occurrence of neurofibrillary tangles in the celiac ganglia." Acta Neuropathol. 78. 448 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 若林孝一: "大脳新皮質における多数の老人斑の出現を特徴とし皮質下諸核の神経細胞脱落を欠く老年期痴呆の一剖検例" 臨床神経. 29. 1163-1167 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Oyanagi,Kiyomitsu: "Correlative decrease of large neurons in the neostriatum and basal nucleus of Meynert in Alzheimer´s disease." Brain Res. 504. 354-357 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Wakabayashi,Koichi: "Lewy bodies in the enteric nervous system in Parkinson´s disease." Arch Histol Cytol. 52(Suppl). 191-194 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Takahashi,Hitoshi: "Occurrence of 15-nm-wide straight tubules in neocortical neurons in progressive supranuclear palsy." Acta Neuropathol. 79. 233-239 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Uchida,Yoko: "Neurotrophic action of Alzheimer´s disease brain extract is due to the loss of inhibitory factors for survival and neurite formation of cerebral cortical neurons." Brain Res. 481. 190-193 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 朝長正徳: "アルツハイマ-病の病因と病理" 日本内科学会雑誌. 78. 1576-1580 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 難波吉雄: "抗ネキシン抗体によるAlzheimer型痴呆脳の免疫組織化学" 医学のあゆみ. 151. 613-614 (1989)

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      1989 Annual Research Report
  • [Publications] 田中真: "老齢マウス脊髄後根神経節培養細胞に及ぼす神経成長因子とガングリオシドの効果〜神経突起伸長効果の定量的検討〜" 日本医誌. 26. 563-567 (1989)

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      1989 Annual Research Report
  • [Publications] 外松明美: "3価鉄ド-パ複合体による生体膜リン脂質過酸化反応" 神経化学. 28. 362-363 (1989)

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      1989 Annual Research Report
  • [Publications] 田中真: "レボドパおよびドパミンによる鉄依存性培養神経細胞障害" 神経化学. 28. 354-355 (1989)

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      1989 Annual Research Report
  • [Publications] Mori,H.: "A distinct from of tau is selectively incorporated into Alzheimer´s paired helical filaments." Biochem Biophys Res Commun. 159. 1221-1226 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Takio,K.: "Identification of beta protein precursor in newborn rat brain." Biochem Biophys Res Commun. 160. 1296-1301 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ihara,Yasuo: "Polypeptide composition of paired helical filaments." Ann Med. 21. 121-125 (1989)

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      1989 Annual Research Report
  • [Publications] Ihara,Yasuo: "What mediate between beta-amyloid and paired helical filaments?" Neurobiol Aging. 10. 573-574 (1989)

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      1989 Annual Research Report
  • [Publications] 西山明子: "ヒトGFAP cDNAの単離とヒトglioma株におけるGFAP発現の検討" 脳腫瘍病理. 6. 125-131 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 西山明子: "バイオテクノロジ-素材としての培養細胞:ヒト癌細胞(II)神経膠腫U-251 MG" 蛋白核酸酵素. 34. 78-79 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Nishiyama,Akiko: "Differential expression of glial fibrillary acidic Protein in human glioma" Acta Neuropathol. 78. 9-15 (1989)

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      1989 Annual Research Report
  • [Publications] Kumanishi,Toshiro: "Primary malignant lymphoma of the brain:demonstration of immunoglobulin gene rearrangements in four cases by the Southern blot hybridization technique" Acta Neuropathol. 79. 23-26 (1989)

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      1989 Annual Research Report
  • [Publications] Kumanishi,Toshiro: "Human GFAP cDNA:cloning and sequence analysis of the coding and the non-coding regions." Acta Neuropathol.

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      1989 Annual Research Report
  • [Publications] Onda Kiyoshi: "Establishment of GFAP-positive human glioma cell lines." Acta Neuropathol.

    • Related Report
      1989 Annual Research Report
  • [Publications] Nagai,Yoshitaka: "Bioactive ganglioside-mediated carbohydrate recognition in coupling with ecto-protein phosphorylation." 1989 Caebohydrate recognition in cellular function.Wiley,Chichester(Ciba Foundation Symposium 145). 145. 119-134 (1989)

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      1989 Annual Research Report
  • [Publications] Nagai,Yoshitaka: "The roles of gangliosides in carbohydrate recognition and signal transduction(novel,ganglioside-dependent ecto protein phosphorylation)" J Neurochem. 52. S4 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Tsuji,S.: "Analysis of ecto-protein kinase activities on the cell surface of several neuronal and glia-like cell lines." J Neurochem. 52. S186 (1989)

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      1989 Annual Research Report
  • [Publications] Itonori,S.: "Involvement of the acyl chain of ceramide in carbohydrate recognition by an anti-glycolipid monoclonal antibody:the case of an anti-melanoma antibody,M2590,to G_<m3>ーganglioside." Glycoconjugate J. 6. 551-560 (1989)

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      1989 Annual Research Report
  • [Publications] Ito,J.: "Induction of astroglial growth inhibition and differentiation by sialosyl cholesterol." Brain Res. 481. 335-343 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kusunoki,S.: "Discrimination of human dorsal root ganglion cells by anti-fucosyl GM1 antibody" Brain Res. 494. 391-395 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kusunoki,S.: "Motor dominant neuropathy and IgM paraproteinemia:the IgM M-protein binds to specific gangliosides." J Neuroimmunol. 21. 177-181 (1989)

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      1989 Annual Research Report
  • [Publications] 宇川義一: "Magneto-electrical stimulation(MES法)-磁気刺激による中枢運動系検査法-" 臨床神経. 29. 8-12 (1989)

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      1989 Annual Research Report
  • [Publications] Matsumura,K: "The immunological homology between two filamentous cross-linker phosphoproteins,connectin and cross-bridge region of neurofilament-H,is not affected by the phosphorylation state." J Biochem. 105. 226-230 (1989)

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      1989 Annual Research Report
  • [Publications] Nakanishi,T.: "Second interim report of the nation-wide collaborative study on the long-term effects of bromocriptine in the treatment of Parkinsonian patients." European Neurology. 29. 3-8 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ono,S.: "Intracytoplasmic inclusion bodies of the thalamus and the substantia nigra,and Marinesco bodies in myotonic dystrophy:a quantitative morphological study." Acta Neuropathol. 77. 350-356 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 苅田典生: "局在する大脳病変を示したadrenomyeloneuropathy" 臨床神経学. 29. 483-487 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ito,Masao: "Long-term depression" Ann Rev Neurosci. 12. 85-102 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ito,Masao: "Long-term desensitization of quisqualate-specific glutamate receptors in Purkinje cells investigated with wedge recording from rat cerebellar slices." Neurosci Res. 7. 168-171 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ito,Masao: "Molecular mechanisms of long-term depression in the cerebellum" Brain Signal Transduction and Memory(eds.Ito,M & Y.Nishizuka). 199-212 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 小柳 清光: 脳と神経. 40. 47-54 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 大浜 栄作: 脳と神経. 40. 109-118 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Oyanagi Kiyomitsu.: Virchows Archiv A. 412. 215-224 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 大原 慎司: 臨床神経学. 28. 303-310 (1988)

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      1988 Annual Research Report
  • [Publications] Ohama Eisaku.: Brain & Dev. 10. 30-35 (1988)

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      1988 Annual Research Report
  • [Publications] Takeda Shigeki.: Acta Neuropathol. 75. 433-440 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 朝長 正徳: アルツハイマー型老年痴呆. (1988)

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      1988 Annual Research Report
  • [Publications] Kameyama Masakuni.: Cerebrovascular disease.(1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ohama Eisaku.: Acta Neuropathol. 76. 11-16 (1988)

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      1988 Annual Research Report
  • [Publications] Ohara Shinji.: Neuropathol Appl Neurobiol. 14. 229-245 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 生田 房弘: いわて医報. 447. 101-117 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ohara Shinji. Alterations of oligodendrocytes and demyelination in the spinal cord of patients with mitochondrial encephalomyopathy.: 86. 19-29 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Takahashi Hitoshi.: Neurology. 38. 1065-1070 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Oyanagi Kiyomitsu.: Brain Res. 458. 218-223 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 西山 明子: バイオテクノロジー素材としての培養細胞, 蛋白質核酸酵素34(1). 78-79 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 萬年 徹: 「疾患からみた神経回路網」 筋萎縮性側索硬化症. 45-57 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Wakabayashi Koichi.: Acta Neuropathol. 76. 217-221 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Wakabayashi Koichi.: Neurosci Lett. 96. 259-263 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 朝長 正徳: BRAIN and NERVE. 40. 57-64 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 朝長 正徳: Dementia. 2. 71-76 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ideda Kazuhiko.: Neurosci Lett. 85. 51-55 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Uchida Yoko.: Biocheimcal & Biophysical Research Communications. 150. 1263-1267 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 豊倉 康夫: 疾患からみた神経回路網. 1988. (1-176)

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  • [Publications] 朝長 正徳: 老人科診療. 9. 203-205 (1988)

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      1988 Annual Research Report
  • [Publications] 下手 公一: 日本老年医学会雑誌. 24. 513-518 (1988)

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      1988 Annual Research Report
  • [Publications] Yamaguchi, H.: Acta Neuropathol. 76. 541-549 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yamaguchi, H.: Acta Neuropathol. 77. 113-119 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kuzuhara, S.: Acta Neuropathol. 75. 345-353 (1988)

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      1988 Annual Research Report
  • [Publications] Uchida, Y.: Biochem Biophys Res Commun. 150. 1263-1267 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ishiguro, K.: J Biochem. 104. 319-321 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ihara, Yasuo.: Brain Res. 459. 138-144 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kondo, J.: Neuron. 1. 827-834 (1988)

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      1988 Annual Research Report
  • [Publications] Mori, H.: Encyclopedia of Neuroscience.

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      1988 Annual Research Report
  • [Publications] Onda Kiyoshi.: Acta Neuropathologica. 76. 433-440 (1988)

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      1988 Annual Research Report
  • [Publications] Kumanishi Toshiro.: Clin Neuropathol. 7. 180 (1988)

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      1988 Annual Research Report
  • [Publications] Tsuji, S.: J Biochem. 104. 498-503 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Tsuji, S.: J Neuochem. 50. 414-423 (1988)

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      1988 Annual Research Report
  • [Publications] Nagai Yoshitaka.: Lectins and Glycoconjugates in Oncology. 59-66 (1988)

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      1988 Annual Research Report
  • [Publications] Nagai Yoshitaka.: 14. 329-350 (1988)

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      1988 Annual Research Report
  • [Publications] Akashi, M.: Blood. 72. 469-479 (1988)

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      1988 Annual Research Report
  • [Publications] Ono, S.: J Neurol Sci. 83. 81-92 (1988)

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      1988 Annual Research Report
  • [Publications] Ito masao.: Ann Rev Neurosci. 12. 85-102 (1989)

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      1988 Annual Research Report
  • [Publications] Ono, S.: Acta Neurol Scand. 77. 102-107 (1988)

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      1988 Annual Research Report
  • [Publications] Kanemaru, K.: Jpn J Med. 27. 74-78 (1988)

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      1988 Annual Research Report
  • [Publications] 葛原 茂樹: 臨床神経. 28. 1274-1281 (1988)

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      1988 Annual Research Report
  • [Publications] 山之内 博: 神経内科. 28. 77-79 (1988)

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      1988 Annual Research Report
  • [Publications] Oyanagi Kiyomitsu: Brain Research. 411. 205-211 (1987)

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      1987 Annual Research Report
  • [Publications] Motegi Takashi: Clinical Neuropathology. 6. 241-245 (1987)

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      1987 Annual Research Report
  • [Publications] 大浜栄作: 神経進歩. 31. 255-269 (1987)

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      1987 Annual Research Report
  • [Publications] 生田房弘: 日本医誌. 98. 1305-1310 (1987)

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  • [Publications] Shimbo Yoshikatsu: Acta Neuropathologica. 74. 1-8 (1987)

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  • [Publications] 朝長正徳: 生体の科学. 38. 194-199 (1987)

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  • [Publications] Iwatsubo T: Revue Neurologique. 143. 605-607 (1987)

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  • [Publications] Ugawa Y: Journal of Neurology. 235. 90-94 (1987)

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  • [Publications] Karachot L: Experimental Brain Research. 66. 229-246 (1987)

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      1987 Annual Research Report
  • [Publications] Kazuhara S: Journal of Neurology. 234. 365-370 (1987)

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      1987 Annual Research Report
  • [Publications] Ono S: Journal of Neurological Science. 83. 81-92 (1988)

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      1987 Annual Research Report
  • [Publications] 豊倉康夫: 日本老年医学会雑誌. 23. 545-551 (1986)

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  • [Publications] 山口晴保: 神経内科. 26. 593-594 (1987)

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  • [Publications] 東海林幹夫: 医学のあゆみ. 141. 227-228 (1987)

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  • [Publications] Mori H: Science. 235. 1641-1644 (1987)

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      1987 Annual Research Report
  • [Publications] Kazuhara S: Acta Neuropathologica.

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      1987 Annual Research Report
  • [Publications] Uvhida Y: Biochemical and Biophysical Research Communications.

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      1987 Annual Research Report
  • [Publications] Tsuji Shuichi: Journal of Neurochemistry.

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  • [Publications] Uchida Yoko: Biochemical and Biophysical Research Communications. 146. 797-801 (1987)

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  • [Publications] 朝長正徳: Clinical Neuroscience. 5. 113 (1987)

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  • [Publications] 朝長正徳: 老人科診療. 8. 439-444 (1987)

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  • [Publications] 朝長正徳: 日本医師会雑誌. 98. 1317-1321 (1987)

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  • [Publications] Tomonaga Masanori: Taniguchi Symposia on Brain Sciences(Strategy and Prospects in Neuroscience). 10. 243-244 (1987)

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      1987 Annual Research Report
  • [Publications] Yamaguchi Haruyasu: Acta Neuropathologica. 72. 214-217 (1987)

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      1987 Annual Research Report
  • [Publications] 萬年徹: "老年神経学(脊髄の老化)" 南江堂, 35-38 (1987)

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      1987 Annual Research Report
  • [Publications] Nagai Yoshitaka: "in "New Trends in Ganglioside Research: Neurochemical and Neuro-regenerative Aspects"(Cell biological significance of gangliosides in neural differentiation and development: Critique and proposal)" R.W.Ledeen et al.Liviana Press,Padova,

    • Related Report
      1987 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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