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The Roles of Calcium in the Pathogenesis of Hypertension.

Research Project

Project/Area Number 62304041
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionWakayama Medical University

Principal Investigator

MASUYAMA Yoshiaki  Wakayama Medical College, Medicine, Professor, 医学部, 教授 (30089164)

Co-Investigator(Kenkyū-buntansha) IMAI Shoichi  Niigata University, Medicine, Professor, 医学部, 教授 (60013869)
FUJITA Takuo  Kobe University, Medicine, Professor, 医学部, 教授 (30009964)
YOSHINAGA Kaoru  Tohoku University, Medicine, Professor, 医学部, 教授 (00004557)
HIDAKA Hiroyoshi  Nagoya University, Medicine, Professor, 医学部, 教授 (80100171)
OGATA Etsuro  University of Tokyo, Medicine, Professor, 医学部, 教授 (70013761)
岸 浩一郎 (岸浩 一郎)  自治医科大学, 医学部, 教授 (50161435)
山下 亀次郎  筑波大学, 臨床医学系, 教授 (80015982)
猿田 享男  慶応義塾大学, 医学部, 教授 (70051571)
Project Period (FY) 1987 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥25,000,000 (Direct Cost: ¥25,000,000)
Fiscal Year 1989: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1988: ¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 1987: ¥15,000,000 (Direct Cost: ¥15,000,000)
KeywordsHypertension / Calcium / Myosin light chain / Protein kinase C / Inositol phosphate / Endothelin / Ca-ATPase / Vascular responsiveness / キナ-ゼII / Ca ATPase / プロスタサイクリン / ナトリウム / 高血圧自然発症ラット / 本態性高血圧 / Ca / Mg / ミオンシン軽鎖 / Cキナーゼ / イノシトールリン脂質 / Ca-ATPaseブラジキニン / プロスタグランディン / 血清由来成長因子 / ビタミンD / 本熊性高血圧 / カルモデュリン
Research Abstract

In the present study, the roles of calcium in the pathogenesis of hypertension, the alteration of calcium metabolism and the antihypertensive effect of calcium supplementation were investigated and following results were obtained.
Phosphorylation of myosin light chain kinase(MLCK) was linked with vascular contraction. Kinase II contributed to the regulation of blood pressure in the central nervous system(Hidaka). Receptor-mediated vascular contraction was mediated by the formation of IP_3 and phosphorylation of MLCK. Protein kinase C inhibited Ca-mobilization from the intracellular Ca store induced by IP_3- Ca-storage mechanism existed in the intracellular Ca store sites(Fujita). G-kinase and C-kinase stimulated Ca^<2+>-ATPase in the vascular cell membrane(Imai). Angiotensin II and vasopressin stimulated the IP_3 formation and mobilized Ca from intracellular Ca store sites. These vasoactive peptides were also activated phospholipase A_2 which stimulated the PGI_2 formation and suppresse … More d the vascular contraction(Yoshinaga). Endothelin produced rapid increase of intracellular free Ca concentration by Ca-mobilization followed by continuous slight increase of free Ca by Ca- influx(Yamashita). Spontaneously hypertensive rats(SHR) showed increased calpain activity In the mesenteric artery(Kishi). Calcium supplementation reduced blood pressure in SHR, Dahl-salt sensitive rats and two-kidney, one clip hypertension. These effects were caused by suppression of vascular responsiveness(Saruta). Calcium supplementation reduced pressor response of mesenteric artery and intracellular free calcium concentration and normalized membrane fluidity of erythrocyte in SOR(Masuyama). Renin-angiotensin system was correlated with antihypertensive effects induced by calcium loading in SIIR and Dahl-salt sensitive rats. In the patients with essential hypertension, metabolism of vitamin D was altered and this alteration contributed to the increase of blood pressure by salt loading.
These results clarify the calcium-mediated intracellular signaling system in the vascular smooth muscle cells, alteration of calcium metabolism in hypertension and the antihypertensive mechanisms of calcium supplementation. Less

Report

(4 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report

Research Products

(220 results)

All Other

All Publications (220 results)

  • [Publications] 増山善明: "The neural and vascular factors in the pathogenesis of hypertension" 高血圧. 11. 133-151 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Baba,A.: "Intracellular free calcium concentration,Ca^<++> channel and calmodulin level in experimental hypertension in rats" Jpn Circ J. 51. 1216-1222 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hano,T.: "Ca mobilization from the intracellular Ca store spontaneously hypertensive rats" J Cardiovascular Pharmacol. 10. s72-s73 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Baba,A: "Effects of nicardipine on blood pressure and pletelet cytosolic free calcium concentration in SHR" J Cardiovascular Pharmacol. 10. s70-s71 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tsuda,K.: "Decreased membrane fluidity of erythrocytes and cultured vascular smooth muscle cells in spontaneously hypertensive rats:an electron spin resonance study" Clinical Science. 75. 477-480 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Masuyama,Y.: "Membrane abnormality of erythrocytes is highly dependent on salt intake and renin profile in essential hypertension:an electron spin resonance" J Hypertens. 6. s266-s268 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Fukuda,K.: "Increased concentracion of calcium channel and intracellular free calcium in the acute phase of deoxycorticosterone acetate salt hypertension" J Hypertens. 6. s261-s263 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tsuda,K: "Creater calmodulin-dependent regulation of neurotransmitter release and vascular responsiveness in chronic DOCA-salt hypertension" Am J Hypertens. 2. 93-98 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 塩谷雅彦: "ラット単離糸球体からのレニン遊離に及ぼすCa拮抗薬の影響について" 薬理と治療. 17. 35-39 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 羽野卓三: "DOCA-食塩高血圧ラットにおけるノルエピネフリン再摂取機構の異常について" 心臓. 21. 67-69 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 塩谷雅彦: "高血圧自然発症ラット単離糸球体からのレニン分泌に及ぼすカルモデュリンの影響について" 日本腎臓学会誌. 31. 859-863 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hano,T.: "Contribution of calmodulin and protein kinase C to renin release in spontaneously hypertensive rats" Am J Hyptertens.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Baba,A: "Responses of cytosolic free calcium to ADP in platelets of spontaneousuly hypertensive rats" Am J Hyptetens.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Fujita,T.: "Hypotensive effects of taurine:Possible involvement of the sympathetic nervous system and endogenous opiates" J Clin Invest. 82. 993-996 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Fujita,T.: "Increased sympatho-adrenomedullary activity and left ventricular hypertrophy in young patients with borderline hypertension" J Mol Cell Cardiol. 22(suppl V). 15-27 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Fujita,T.: "Attnuated vasodilator responses to magnesium in young patients with borderline hypertension" Circulation.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Fujita,T.: "Systemic and regional hemodynamics in patients with salt-sensitive hypertension" Hypertension.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Saitoh,M: "Selective inhibition of catalytic activity of smooth muscle myosin lighc chain kinase" J Biol Chem.262. 7796-7801 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hagiwara,M.: "Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors,isoquinolinesulfonamide derivatives" Mol Pharmacol. 32. 7-12 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Asano,T.: "Mechanism of action of a nnvel antivasospasm drug,HA1077" J Pharmacol Exp Ther. 241. 1033-1040 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sasaki,Y.: "Disorganization by calcium antagonists of action microfilament in aortic smooth muscle cells" Am J Physiol. 253. c71-c78 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hagiwara,M.: "Thyroid hormones inhibit the Ca^<2+> calmodulin-induced activation of myosin light chain kinase" Biochem Biophys Res Commun. 152. 270-276 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ishihara,T.: "ML-9 inhibits the vascular contraction via the inhibition of myosin light chain phosphorylation" Mol Pharmacol. 33. 598-603 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ikebe,M.: "Correlation of conformation and phosphorylation and dephosphorylation of smooth muscle myosin" J Biol Chem. 263. 10698-10704 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ishikawa,T.: "Thyroid hormones directly interact with vascular smooth muscle stripes" Mol Pharmacol. 35. 760-765 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hagiwara,M.: "Monoclonal antibody assessment of tissue-and species-specific myosin light chain kinase isozymes" J Biochem. 106. 71-75 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tokumitsu,H.: "Anti-gizzard MLCk monoclonal antibody MM13 inhibits superprecipitation and phosphorylation of bovine aortic smooth muscle actomyosin" J Biochem. 106. 511-514 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hidaka,H.: "Role of protein phosphorylation in Ca^<2+> regulated intracellular messenger systems" Microcirc Endoth Lymphatics. 5. 13-29 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tokumitsu,H.: "KN-62(1-No-bis-5-isoquinolinesulfonyl-N-methyl-Lーtyrosyl-4-phenylpiperazine)specific inhibitor of Ca^2 calmodulin-dependent protein kinase" J Biochem chem.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Asano,T.: "Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase" Br J Pharmacol. 98. 1091-1100 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hagiwara,M: "Selective binding of L-thyroxine to calmodulin-binding domain of myosin light chain kinase" J Biol Chem. 264. 40-44 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takeuchi,K.: "Difference between the effects of atrial natriuretic peptide and calcium antagonist on cytosolic free calcium in cultured vascular smooth muscle cells" J Cardiovas Pharmacol. 13(suppl 6). s13-s16 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takeuchi,K.: "Intracellular compartmentalization of fura-2 dye demonstrated by laser excitation fluorescence microscopy:a problem in measuring cytosolic free calcium concerntration using fura-2 fluorescence in vascular smooth muscle cells" Tohoku J Exp Med. 159. 23-35 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takeuchi,K.: "Phosphoinositide hydrolysis and calcium mobilization induced by angiotensin II and vasopressin in cultured vascular smooth muscle" Kidney Int.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takata,S.: "Concomitant omcrease om cytosolic free calcium and phosphorylation of myosin light chain by vasoconstrictive hormones in cultured rat vascular smooth muscle cells" Endocrinol Japon. 35. 577-584 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takata,S.: "Phorbol ester modulates serotonin receptor-mediated increases in inositol phosphate production and calcium mobilization in cultured rat vascular smooth muscle cells" FEBS Lett. 234. 228-230 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hirata,Y.: "Calcitonin gene-related peptide receptor in cultured vascular smooth muscle cells" Biochem Biophys Res Commun. 151. 1113-1121 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takagi,Y.: "Effects of protein kinase inhibitors on growth factor-stimulated DNA synthesis in cultured rat vascular smooth muscles cells" Atherosclerosis. 74. 227-230 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takata,S.: "Cellular mechanism of action by vasoconstrictor hormons in cultured rat vascular smooth muscle cells" Am J Hypertens.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 高木康行: "血管由来成長因子の血管平滑筋細胞での増殖機構" 血管. 12. 62-72 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 吉田豊: "血管平滑筋に存在する2種類の高親和性(Ca^<2+>+Mg^<2+>)-ATPase:Ca^<2+>pumpとの関連" 心筋の構造と代謝. 11. 461-474 (1988)

    • Description
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      1989 Final Research Report Summary
  • [Publications] Yoshida,Y.: "Two high affinity(Ca^<2+>+Mg^<2+>)-ATPase of vascular smooth muscle plasma membrane preparation:Their relation to the Ca^<2+>-pumping ATPase" Am J Hypertens.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takuwa,Y.: "Endothelin receptor is coupled to phospholipase C via a pertussin toxin-insensitive guanine nucleotide binding regulatory protein in vascular smooth muscle cells" J Clin Invest.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Nakamura,R.: "Effects of calcium supplementation on blood pressure in essential hypertensive subjects" Jpn J Med. 26. 203-206 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kageyama,Y.: "Effects of calcium loading in DOCA-salt hypertensive rats" Jpn Circ J. 51. 1315-1324 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kageyama,Y.: "Oral calcium treatment lowers blood pressure in renovascular hypertensive rats by suppressing the renin-angiotensin system" Hypertension. 10. 375-382 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kusaka,M.: "Does so-called stereptozocin hypertension exist in rats?" Hypertension. 10. 517-521 (1987)

    • Description
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    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kusaka,M.: "Antihypertensive treatment in spontaneously hypertensive rats with stereozotocin-induced diabetes mellitus" Acta Physiol Hungarica. 71. 251-269 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kishi,K.: "Possible mechanisms of abnormal norepinephrine sensitivity and the development of hypertension in spontaneously hypertensive rats:a hypothesis" Am J Hypertens.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hidaka,H.: "Progress in Clinical Biochemistry and Medicine Vol.5" Springer-Verlag,Berlin Heidelberg, 18 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hagiwara,M.: "Regulation and Contraction of Smooth Muscle(ed.by Siegman,M.et al.)" Alan R.Liss,Inc.,New York, 12 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hidaka,H.: "Pharmacology(ed. by Rand,M.J.et al.)" Elsevier Science Publishers,B.V.,Amsterdam, 7 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hagiwara,M.: "Biosignalling in Cardiac and Vascular System(ed.by Fujiwara,M et al.)" Pergamon Press,England, 4 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hidaka,H.: Raven Press,New York, 1988 (AdvancesinSecondMessengerandPhosphoproteinResearch(ed)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tanaka,T.: "Calcium Protein Signaling(ed.by Hidala,H.)" Plenum Press,New York, 7 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takeuchi,K.: "Renal Function,Hypertension and Kallikrein-kinin system(ed.by Iimura,O.et al.)" 5 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takeuchi,K.: "Biosignalling in Cardiac and Vascular System(ed.by Fujiwara,M.et al.)" Pergamon press,England, 4 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Imai,S.: "Calcium Protein Signaling(ed.by Hidaka,H.)" Plenum Press,New York, 10 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Masuyama: "The neural and vascular factors in the pathogenesis of Hypertension" Jpn J Hypertens. 11(2). 133-151 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] A. Baba et al.: "Intracellular free calcium concentration, Ca^<++> channel and calmodulin level in experimental hypertension in rats." Jpn Circ J 51(10):1216-1222 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Hano et al.: "Ca mobilization from the intracellular Ca store in spontaneously hypertensive rats" J Cardiovascular Pharmacol 10:s72-73, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] A. Baba et al.: "Effects of nicardipine on blood pressure and pletelet cytosolic free calcium concentration in SHR" J Cardiovascular Pharmacol 10:s70-71, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K. Tsuda et al.: "Decreased membrane fluidity of erythrocytes and cultured vascular smooth muscle cells in spontaneously hypertensive rats: an electron spin resonance study" Clinical Science 75:477-480, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Masuyama et al.: "Membrane abnormality of erytyrocytes is highly dependent on salt intake and renin profile in essential hypertension: an electron spin resonance study" J Hypertens 6:s266-268, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K. Fukuda et al.: "Increased concentration of calcium channel and intracellular free calcium in the acute phase of deoxycorticosterone acetate salt hypertension" J Hypertens 6:s261-263, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K. Tsuda et al.: "Greater calmodulin-dependent regulation of nerotransmitter release and vascular responsiveness in chronic DOCA-salt hypertension" Am J Hypertens 2:93-98, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M. Shiotani et al.: "Effects of Calcium-Antagonist on renin release from isolated rat glomeruli" Jpn Pharmacol Ther 17:35-39, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Hano et al.: "Alteration of norepinephrine uptake in DOCA-salt hypertension (in Japanese)" Heart 21:67-69 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M. Shiotani et al.: "Contribution of calmodulin to renin release in spontaneously hypertensive rats. (in Japanese)" Jpn J Nephrol X X X I 859-863, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Hano et al.: "Contribution of calmodulin and protein kinase C to renin release in spontaneously hypertensive rats." Am J Hypertens.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] A. Baba et al.: "Responses of cytosolic free calcium to ADP in platelets of spontaneously hypertensive rats." Am J Hypertens.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Fujita et al.: "Hypotensive effects of taurine: Possible involvement of the sympahtetic nervous system and endogenous opiates" J Clin Invest 82:993-996, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Fujita et al.: "Increased sympatho-adrenomedullary activity and left ventricular hypertrophy in young patients with borderline hypertension" J Mol Cell Cardiol 22(suppl V):15-27, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Fujita et al.: "Attenuated vasodilator responses to magnesium in young patients with borderline hypertension" Circulation.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Fujita et al.: "Systemic and regional hemodynamics in patients with salt-sensitive hypertension" Hypertension.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M. Saitoh et al.: "Selective inhibition of of catalytic activity of smooth muscle myosin light chain kinase" J. Biol Chem 262:7796-7801 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M. Hagiwara et al.: "Selective modulation of cacium-dependent myosin phosphorylation by movel protein kinase inhibitors, isoquinolinesulfonamide derivatives" Mol Pharmacol 32:7-12, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Asano et al.: "Michanism of action of a novel antivasospasm drug, HA1077" J Pharmacol Exp Ther 241(3):1033-1040, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Sasaki et al.: "Disorganization by calcium antagonists of actin microfilament in aortic smooth muscle cells" Am J Physiol 253(2):C71-78, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M. Hagiwara et al.: "Thyroid hormones inhibit the Ca^<2+> caomodulin-induced activation of myosin light chain kinase" Biochem Biophys Res Commun 152(1):270-276, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Ishihara et al.: "ML-9 inhibits the vascular contraction via the inhibition of myosin light chain phosphorylation" Mol Phrmacol 33:598-603, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M. Ikebe et al.: "Correlation of conformation and phosphorylation and dephosphorylation of smooth muscle myosin" J Biol Chem 263(22) 10698-10704, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Ishikawa et al.: "Thyroid hormones directly interact with vascular smooth muscle strips" Mol Phrmacol 35:760-765, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M. Hagiwara et al.: "Monoclonal antibody assessment of tissue- and species- specific myosin light chain kinase isozymes" J Biochem 106(1):71-75, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] H. Tokumitsu et al.: "Anti-gizzard MLCK monoclonal antibody MM13 inhibits superprecipitation and phosphorylation of bovine aortic smooth muscle sctomyosin" J Biochem 106(3) 106(3):511-514, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] H. Hidaka et al.: "Role of protein phosphorylation in Ca^<2+> regulated intracellular messenger systems" Microcirc Endoth Lymphatics 5:13-29 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] H. Tokumitsu et al.: "KN-62(1- [No-bis-5-isoquinolinesulfonyl] -N-methyl-L-tyrosyl-4-phenylpiperazine) specific inhibitor of Ca^<2+> calmodulin-dependent protein kinase II" J Biol Chem.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Asano et al.: "Vasodilator actions of HA 1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase" Br J Pharmacol 98:1091-1100, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M. Hagiwara et al.: "Selective binding of L-thyroxine to calmodulin-binding domain of myosin light chain kinase" J Biol Chem 264(1):40-44, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K. Takeuchi et al.: "Difference between the effects of atrial natriuretic peptide and calcium antagonist on cytosolic free calcium in cultured vascular smooth muscle cells" J Cardiovas Pharmacol 13(supple 6):s13-16, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K. Takeuchi et al.: "Intracellular cpmpartmentation of fura-2 dye demonstrated by laser excitation fluorescence microscopy: a problem in measuring cytosolic free calcium concentration using fura-2 fluorescence in vascular smooth muscle cells." Tohoku J Exp Med 159:23-35, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] R.Nakamura et al.: "Effects of calcium supplementation on blood pressure in essential hypertensive subjects" Jpn J Med 26 203-206, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Kageyama et al.: "Effects of calcium loading in DOCA-salt hypertensive rats" Jpn Circ J 51:1315-1324, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Kageyama et al.: "Oral calcium treatment lowers blood pressure in renovascular hypertensive rats by suppressing the renin-angiotensin system" Hypertension 10:375-382, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M.Kusaka et al.: "Does so-called stereptozocin hypertension exist in rats?" Hypertension 10(5), 517-521, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M.Kusaka-Nakamura et al.: "Antihypertensive treatment in spontaneously hypertensive rats with stereozotocininduced diabetes mellitus." Acta Physiol Hungarica 71(2) 251-269, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K.Kishi et al.: "Possible mechanisms of abnormal norepinephrine sensitivity and the development of hypertension in spontaneously hypertensive rats; a hypothesis" Am J Hypertens.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K.Tsuda et al.: "Effects of calcium and calcium antagonist on neurosecretion and vascular responsiveness in renal vasculature" Microcirculation -an update, vol 2 M.Tsuchiya et al. p477-478, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T.Hano et al.: "Intracelluar calcium sore in spontaneously hypertensive and DOCA-salt hypertensive rat." Biosignaling in Cardiac and Vascular System M.Fujiwara, S.Narumiya S.Miwa p393-396, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] H.Hidaka et al.: "Biophrmacological regulation of protein phosphorylation" Progress in Clinical Biochemistry and Medicine, Vol 5 p25-42, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M.Hagiwara et al.: "Selective inhibitors of phosphorylation in smooth muscle" Regulation and Contraction of Smooth Muscle M.Siegman, A.P.Somlyo, N.L.Stephens p251-262, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] H.Hidaka et al.: "Myosin phosphorylation inhibitors and vascular contraction" Pharmacology M.J. Rand, C.Raper, p393-399, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M.Hagiwara et al.: "Modulation of Ca^<2+> calmodulin-dependent myosin phosphorylation by three types of inhibitors" Biosignaling in Cardiac and Vascular System M.Fujiwara, S.Narumiya S.Miwa p267-270, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K.Takeuchi et al.: "Phosphoinositide hydrolysis and calcium mobilization induced by angiotensin II and vasopressin in cultured vascular smooth muscle" Kidney Int.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] S.Takata et al.: "Concomitant increase in cytosolic free calcium and phosphorylation of myosin light chain by vasoconstrictive hormones in cultured rat vascular smooth muscle cells" Endocrinol Japon 35(4), 577-584, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] S.Takata et al.: "Phorbol ester modulates serotonin receptor-mediated increases in inositol phosphate production and calcium mobilization in cultured rat vascular smooth muscle cells" FEBS Lett. 234(1) 228-230, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Hirata et al.: "Calcitonin gene-related peptide receptor in cultured vascular smooth muscle cells" Biochem Biophys Res Commun 151(3):1113-1121, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Takagi et al.: "Effects of protein kinase inhibitors on growth factor-stimulated DNA synthesis in cultured rat vascular smooth muscle cells" Atherosclerosis 74:227-230, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] S.Takata et al.: "Cellular mechanism of action by vasoconstrictor hormons in cultured rat vascular smooth muscle cells" Am J Hypertens.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Takagi et al.: "Growth mechanisms of PDGF and EGF in vascular smooth muscle cells (in Japanese)" Jpn Circ Research 12:67-71, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Yoshida et al.: "Two high affinity (Ca^<2+>+Mg^<2+>)-ATPases in vascular smooth muscle cells: Their relation to the Ca^<2+> - pumping ATPase" Shinkinn no kozo to taisha 11:461-474, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Yoshida et al.: "Two high affinity (Ca^<2+>+Mg^<2+>)-ATPases of vascular smooth muscle plasma membrane preparation: Their relation to the Ca^<2+> -pumping ATPase" Am J Hypertens.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Takuwa et al.: "Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide binding regulatory protein in vascular smooth muscle cells" J Clin Invest.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] H.Hidaka et al.: "Ca^<2+>, phospholipid and Ca^<2+>, calmodulin-dependent myosin light chain phosphorylation of smooth muscle and non-muscle cells" Advances in Second Messenger and Phosphoprotein Research R.Adelstein, C.Klee, M.Rodbell vol.21, p95-100, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T.Tanaka et al.: "Calcium signaling of calcium-binding proteins and drug actions" Calcium Protein Signaling H.Hidaka vol. 255, p165-171, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K.Takeuchi et al.: "Relationship between bradykinin-induced rise in cytosolic free calcium and prostacyclin synthesis in cultured vascular smooth muscle cells" Renal Function, Hypertension and Kallilrein-Kinin System Iimura O and Margolius HS 117-121, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K.Takeuchi et al.: "Bradykinin stimulated phosphoinositolysis in cultured vascular smooth muscle cells" Biosignaling in Cardiac and Vascular System M.Fujiwara, S.Narumiya S.Miwa 335-338, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] S.Imai et al.: "Sarcolemmal(Ca^<2+>+Mg^<2+>)- ATPase of vascular smooth muscle" Calcium Protein Signaling 91-100, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 増山善明: "The neural and vascular factors in the pathogenesis of hypertension" 高血圧. 11. 133-151 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Tsuda,K.: "Greater calmodulin-dependent regulation of neurotransmitter release and vascular responsiveness in chronic DOCA-salt hypertension" Am J Hypertens. 2. 93-98 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 塩谷雅彦: "ラット単離糸球体からのレニン遊離に及ぼすCa拮抗薬の影響について" 薬理と治療. 17. 35-39 (1989)

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      1989 Annual Research Report
  • [Publications] 羽野卓三: "DOCA-食塩高血圧ラットにおけるノルエピネフリン再摂取機構の異常について" 心臓. 69. 67-69 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 塩谷雅彦: "高血圧自然発症ラット単離糸球体からのレニン分泌に及ぼすカルモデュリンの影響について" 日本腎臓学会誌. 31. 859-863 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hano,T.: "Contribution of calmodulin and protein kinase C to renin release in spontaneously hypertensive rats" Am J Hypertens.

    • Related Report
      1989 Annual Research Report
  • [Publications] Baba,A.: "Responses of cytosolic free calicium to ADP in platelets of spontaneously hypertensive rats" Am J Hypertens.

    • Related Report
      1989 Annual Research Report
  • [Publications] Fujita,T.: "Increased sympatho-adrenomedullary activity and left ventricular hypertrophy in young with borderline hypertension" J Mol Cell Cardiol. 22(Suppl V). 15-27 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Fujita,T.: "Attenuated vasodilator responses to magnesium in young patients with borderline hypertension" Circulation.

    • Related Report
      1989 Annual Research Report
  • [Publications] Fujita,T.: "Systemic and regional hemodynamics in patients with salt-sensitive hypertension" Hypertension.

    • Related Report
      1989 Annual Research Report
  • [Publications] Hagiwara,M.: "Selective binding of L-thyroxine to calmodulin-binding domain of myosin light chain kinase" J Biol Chem. 264. 40-44 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ishikawa,T.: "Thyroid hormones directly interact with vascular smooth muscle strips" Mol Pharmacol. 35. 760-765 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hagiwara,M.: "Monoclonal antibody assessment of tissue- and species-specific myosin light chain kinase isozymes" J Biochem. 106. 71-75 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Tokumitsu,H.: "Anti-gizzard MLCK monoclonal antibody MM13 inhibits super-precipitation and phosphorylation of bovine aortic smooth muscle actomyosin" J.Biochem. 106. 511-514 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hidaka,H.: "Role of protein phosphorylation in Ca^<2+> regulated intracellular messenger systems" Microcirc Endoth Lympatics. 5. 13-29 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Tokumitsu,H.: "KN-62(1-[No-bis-5-isoquino-linesulfonyl]-N-methyl-L-tyrosyl-4-phenylpiperazine)specific inhibitor of Ca^<2+> calmodulin-dependent protein kinase II" J Biol Chem.

    • Related Report
      1989 Annual Research Report
  • [Publications] Asano,T.: "Vasodilator actions of HA 1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase" Br J Pharmacol. 98. 1091-1100 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Takeuchi,K.: "Difference between the effects of atrial natriuretic peptide and calcium antagonist on cytosolic free calcium in cultured vascular smooth muscle cells" J Cardiovas Pharmacol. 13(Suppl 6). s13-s16 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Takeuchi,K.: "Intracellular compartmentation of fura-2 dye demonstrated by laser excitation fluorescence microscopy:a problem in measuring cytosolic free calcium concentration using fura-2 fluorescence in vascular smooth muscle cells" Tohoku J Exp Med. 159. 23-35 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Takeuchi,K.: "Phosphoinositide hydrolysis and calcium mobilization induced by angiotensin II and vasopressin in cultured vascular smooth muscle" Kidney Int.

    • Related Report
      1989 Annual Research Report
  • [Publications] Takata,S.: "Cellular mechanism of action by vasconstrictor hormons in cultured rat vascular smooth muscle cells" Am J Hypertens.

    • Related Report
      1989 Annual Research Report
  • [Publications] 高木康行: "血管由来成長因子の血管平滑筋細胞での増殖機構" 血管. 12. 62-72 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Yoshida,Y.: "Two high affinity(Ca^<2+>+Mg^<2+>)-ATPases of vascular smooth muscle plasma membrane preparation:Their relation to the Ca^<2+>-pumping ATPase" Am J Hypertens.

    • Related Report
      1989 Annual Research Report
  • [Publications] Takuwa,Y.: "Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide binding regulatory protein in vascular smooth muscle cells" J Clin Invest.

    • Related Report
      1989 Annual Research Report
  • [Publications] Hano,T.: "Biosignaling in Cardiac and Vascular System(ed.by Fujiwara,M.,et al)" Pergamon Press,England, 4 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hagiwara,M.: "Biosignaling in Cardiac and Vascular System(ed.by Fujiwara,M.,et al)" Pergamon Press,England, 4 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Tanaka,T.: "Calcium Protein Signaling(ed.by Hideka,H.)" Plenum Press,New York, 6 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Takeuchi,K.: "Biosignaling in Cardiac and Vascular System(ed.by Fujiwara,M.et al)" Pergamon Press,England, 4 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Imai,S.: "Calcium Protein Signaling(ed.by Hidaka,H.)" Plenum Press,New York, 10 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Baba,A.: Am J Hypertension. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Hano,T.: Am J Hypertension.

    • Related Report
      1988 Annual Research Report
  • [Publications] Tsuda,K.: Am J Hyperyension. 1. 283-286 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Tsude,K.: Clin and Exp Hyper-Theory and Practicet. A10. 1051-1064 (1988)

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      1988 Annual Research Report
  • [Publications] Fujita,T.: J Clin Invest. 82. 993-997 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ito,Y.: Jpn Circ J. 52. 1326-1334 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yamato,H.: Endocrinology. 124. 511-517 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ikebe,M.: J Biol Chem. 263. 10698-10704 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Hagiwara,M.: J Biol Chem. 264. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ishikawa,T.: Mol Pharmacol. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Takeuchi,K.: Kidney International. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Takeuchi,K.: J Cardiovasc Pharmacol. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Takeuchi,K.: Endocrinol Japon. 36. 31-37 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Nakai,M.: Biochem Biophys Research Comm. 152. 1416-1420 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ohno,T.: Pfugers Archiv.

    • Related Report
      1988 Annual Research Report
  • [Publications] Fujita,T.: Calcium Channel, Structure, Function and Implications. 635-639 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Takagi,Y.: Atherosclerosis. 74. 227-230 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Takata,S.: FEBS Letters. 234. 228-230 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Imai,S.: Brit Pharmacol. 94. 347-354 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ochi,S.: J Cardiovasc Pharmacol. 11. 326-331 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ishibashi,T.: Cardiovasc Res. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Imai,S.: Calcium-Binding Proteins 1988. (1989)

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      1988 Annual Research Report
  • [Publications] Ishibashi,T.: Artneimittel-Forshung. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kawada,T.: Brit j Pharmacol. 96. (1989)

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      1988 Annual Research Report
  • [Publications] Kishi,K.: Jpn J pharmacol. 46. 41 (1988)

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      1988 Annual Research Report
  • [Publications] Inoue,T.: Jpn J Pharmacol. (1989)

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      1988 Annual Research Report
  • [Publications] Inoue,T.: Hypertension. (1989)

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      1988 Annual Research Report
  • [Publications] Iwanaga,R.: Life Science. 42. 1279-1286 (1988)

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      1988 Annual Research Report
  • [Publications] Tominaga,T.: Life Science. 42. 1861-1868 (1988)

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      1988 Annual Research Report
  • [Publications] Hano,T.: "Intracellular calcium store in spontaneously hypertensive and DOCA-salt hypertensive rats.In "Proceeding of The International Symposium on Biosingnalling in Cardiac and Vascular S" Pergamon Press Inc.,Oxford, (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Hidaka,H.: "Calcium Signal and Cell Response" Japan Scientific Scieties Press,Springer-Verlag, 7 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Takeuchi,K.: "Relationship Between bradykinin-induced rise in cytosolic free calcium and prostacyclin synthesis in cultured vascular smooth muscle cells.In"Renal Function, Hypertension and Kall" University of Tokyo Press, 5 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Takeuchi,K.: "Bradtkinin stimulate phosphinositide hydrolysis in cultured vascular smooth muscle cells.In "Biosignalling in Cardiac and Vascular System"." Pergamon Press Inc.,Oxford, (1989)

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      1988 Annual Research Report
  • [Publications] Abe,K.: "The role of renal prostaglandin and kallikrein-kinin system in the renal excretory function and blood pressure.In "Renal Function,Hypertension and Kallikrein -kinin System"." University of Tokyo Press, 5 (1988)

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      1988 Annual Research Report
  • [Publications] Fujita,T.: "Calcium and Your Health" Japan Peblications, 132 (1987)

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      1988 Annual Research Report
  • [Publications] 永野充: "心臓代謝実験法" 医歯薬出版株式会社, 410 (1988)

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      1988 Annual Research Report
  • [Publications] Tsuda,K.: J.Hypertens.4(Suppl 5). S49-S51 (1986)

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      1987 Annual Research Report
  • [Publications] Tsuda,K.: J.Hypertens.4(Suppl 5). S57-S59 (1986)

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      1987 Annual Research Report
  • [Publications] Tsuda,K.: J.Hypertens.4(Suppl 6). S206-S208 (1986)

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      1987 Annual Research Report
  • [Publications] Tsuda,K.: Jpn.Circ.J.51. 25-32 (1987)

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      1987 Annual Research Report
  • [Publications] Tsuda,K.: Jpn.Heart J.28. 427-434 (1987)

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  • [Publications] Tsuda,K.: Hypertension. 9(Suppl III). III-19-III-24 (1987)

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  • [Publications] Baba,A.: Jpn.Circ.J.51. 1216-1222 (1987)

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  • [Publications] Kojima,I.: J.Biol.Chem.262. 4057-4063 (1987)

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  • [Publications] Matsunaga,H.: Pfueger Archives. 408. 351-355 (1987)

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  • [Publications] Matsunaga,H.: Biochem.Biophys.Re.Commun.(1988)

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  • [Publications] Saitoh,M.: J.Biol.Chem.262. 7796-7801 (1987)

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  • [Publications] Hidaka,H.: T.I.P.S.8. 162-164 (1987)

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  • [Publications] Hagiwara,M.: Mol.Pharmacol.7-12 (1987)

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  • [Publications] Ito,M.: Biochem.Biophys.Res.Commun.

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  • [Publications] Matsushima,S.: Biochem.Biophys.Res.Commun.148. 1468-1474 (1987)

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  • [Publications] Inagaki,M.: Arch.Biochem.Biophy.254. 136-141 (1987)

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  • [Publications] 竹内和久: 薬理と治療. 15S. 151-157 (1987)

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  • [Publications] Takeuchi,K.ed.,Iimura O,Margolius HS: Proceedings of Symposium on Renal Function,Hypertension and Kallikrein-Kinin System,Sapporo,1987,Tokyo University Press,Tokyo.

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  • [Publications] Takeuchi,K.: Proceedings of the International Conference'Calcium Signal and Cell Response:Biological and Clinical Aspects',Sapporo,1987(ed.,Yagi,K et al).

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  • [Publications] Tamita,M.: Endocrinol.Jpn.34. 313-318 (1987)

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  • [Publications] Takata,S.: Endocrinol.Jpn.

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  • [Publications] 吉田豊: 日本薬理学雑誌. 91. 12p (1988)

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  • [Publications] Fujita,T.: J.Clin.Investigat.80. 832-840 (1987)

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  • [Publications] Nojima,H.: J.Hypertens.4(Suppl 3). S275-S277 (1986)

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  • [Publications] Kawashima,H.: J.Hypertens. 4(Suppl 3). S287-S289 (1986)

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  • [Publications] Nojima,H.: J.Mol.Biol.190. 391-400 (1986)

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  • [Publications] Nojima,H.: J.Mol.Biol.193. 439-445 (1987)

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  • [Publications] Nojima,H.: Mol.Cell.Biol.7. 1873-1880 (1987)

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  • [Publications] Nojima,H.: FEBS Lett.217. 187-190 (1987)

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  • [Publications] Nakamura,R.: Jpn.J.Med.26. 203-206 (1987)

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  • [Publications] Kageyama,Y.: Jpn.Circl J.51. 1315-1324 (1987)

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  • [Publications] Kageyama,Y.: Hypertension. 10. 375-382 (1987)

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  • [Publications] Hidaka,H.: "Progress in Clinical Biochemistry and Medicine" Springer-Verlag,Berlin,

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  • [Publications] Hagiwara,M.: "Regulation and Contraction of Smooth Muscle" ARL,New York, 12 (1987)

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  • [Publications] Takeuchi,K.ed.by Abe,K.: "Kinin V" Plenum Publisher,CO.,New York,

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  • [Publications] Hirata,Y.ed.by Massry,SC.: "New Actions of PTH" Plenum Press,New York,

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  • [Publications] Kishi,K.ed.by Nakamura,K.: "Ca^<2+>-calmodulin activity in the brain of spontaneously hypertensive rats in"Brain and Blood Pressure Control"" Elsevier Science Publishers,Amsterdam, 6 (1986)

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Published: 1987-03-31   Modified: 2016-04-21  

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