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Relationship between the concentration of serum lipids and dietary factors in Zen monks.

Research Project

Project/Area Number 62304053
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 医学一般
Research InstitutionKyoto University

Principal Investigator

TORU KITA  Kyoto University, 医学部 (60161460)

Co-Investigator(Kenkyū-buntansha) 中谷 矩章  東海大学, 医学部, 助教授
YUJI MATSUZAWA  Osaka University, 医学部, 講師 (70116101)
KOREAKI NAKAYA  Tokai University
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥7,400,000 (Direct Cost: ¥7,400,000)
Fiscal Year 1988: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1987: ¥5,400,000 (Direct Cost: ¥5,400,000)
Keywordscholesterol / dietary factors / LDL / fatty acids / Zen monks / 血小板 / 禅宗 / LDLコレステロール / 不飽和 / 飽和脂肪酸
Research Abstract

In Japan the incidences of heart attacks and cerabral srtokes are rapidly increasing, which correlates with a greater consumption of Western style food. Epidemiologic surveys conducted in many countries over the past 30years have all shown that atherosclerosis becomes more severe as the mean LDL level rises in a population. In Japan, it is well known that Zen monks have long life span, possibly because of their diet. In this study, we focused on their serum lipid levels and dietary habits.
The mean levels of total cholesterol and LDL-cholesterol were 28.5, and 32.8% lower in Zen monks than in control Japanese males. There were no significant difference in the level of triglyceride in both groups. The mean levels of total and LDL-cholesterol were almost same in both caucasian and Japanese Zen monks and were apparently lower than that in control Japanese males. This suggested that there are no race difference in the level of serum cholesterol when people eat animal product-free diet. In addition, the serum lipid levels in Zen monks before they started thraining were compared with those 6 months after they underwent training. The mean levels of total and LDL-cholesterol decreased by 18.1 and 16.3%, respectively. The results of the nutritional intake revealed differences between Zen monks and control males. No significant differences were observed between the groups in mean intake of total calories. Zen monks consumed virtually no cholesterol or animal products (fat protein) and ate only vegetable fats with an extremely high ration of polyunsaturated to saturated fat (P/S ratio). These data suggest that the dietary habits of Zen monks give rise to relatively low levels of LDL-cholesterol. We are now planning to investigate what factors in fatty acids influence serum cholesterol level.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Kita,T.;Yokode,M.;Kume,N.;Ishii,K.;Nagano,Y.;Mikami,A.;Kita,M.;Fuhii,K.;Kawai,C.;Domae,N.;Ishihara,H.;Kimura,M.;Itokawa,Y.: Jap.Circl.J.52. 99-104 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kita,T.;Nagano,Y.;Yokode,M.;Ishii,K.;Kume,N.;Narumiya,S.;Kawai,C.: Am.J.Cardiol.62. 13B-19B (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Wu,D-J.;Fujiwara,H.;Tanaka,M.;Onodera,T.;Matsuda,M.;Ishida,M.;KAwamura,A.;Takemura,G.;Fujiwara,T.;Nagano,Y.;Ishii,K.;Kita,T.;Kawai,C;Hamashima,Y.: Jap.Circl.J.52. 327-340 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yokode,M.;Kita,T.;Arai,H.;Kawai,C.;Naruniya,S.:Fujiwara,M.: Proc.Natl.Acad.Sci.U.S.A.85. 2344-2348 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ishii,K.;Kita,T.;Kume,N.;Nagano,Y.;Kawai,C.: Biochim.Bhiophys.Acta. 962. 387-389 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kamido,H.;Matsuzawa,Y.;Tarui,S.: Lipids. 23. 917-923 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yokode,M.;Kita,T.;Narumiya,S.;Kawai,C.: Advance in Prostaglandin, Thromaboxane, and Leukotrinene Research. 17. 229-232 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kita,T.;Kume,N.;Tsujita,Y.;Ito,T.;Qatanbe,Y.;Kawai,C.: Drugs Affecting Lipid Metabolism. 251-254 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kita, T.,;Yokode, M.,;Kume, N.,;Ishii, K.,;Nagano, Y.,;Mikami, A.,;Kita, M.,;Fujii, K.,;Kawai, C.,;Domae, N.,;Ishihara, H.,;Kimura, M.; Itokawa, Y.: "The concentration of serum lipids in Zen monks and control males in Japan." Jap. Circl. J.52. 99-104 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kita, T.,;Nagano, Y.,;Yokode, M.,;Ishii, K.,;Kume, N.,;Narumiya, S.,;Kawai, C.: "Prevention of atherosclerotic progerssion in Watanabe rabbits by probucol." Am. J. Cardiol.62. 13-19 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Wu, D-J.,;Fujiwara, H.,;Tanaka, M.,;Onodera, T.,;Matsuda, M.,;Ishida, M.,;Kawamura, A.,;Takemura, G.,;Fujiwara, T.,;Nagano, Y.,;Ishii, K.,;Kita, T.,;Kawai, C.; Hamashima, Y.: "Distribution and progression of coronary arterial and aortic lesions in the conventional WHHl rabbit -quantitative analysis-." Jap. Circl. J.52. 327-340 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yokode, M.,;Kita, T.,;Arai, H.,;Kawai, C.,;Narumiya, S.,;Fujiwara, M.: "Cholesteryl ester accumulation in macrophages incubated with low density lipoprotein pretreated with cigarette smoke extract." Proc. Natl. Acad. Sci. U.S.A.85. 2344-2348 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ishii, K.,;Kita, T.,;Kume, N.,;Nagano, Y.,;Kawai, C.: "Uptake of acetylated LDL by peritoneal macrophages obtained from normal and Watanabe heritable hyperlipidemic rabbits, an animal model for familial hypercholesterolemia." Biochim. Biophys. Acta. 962. 387-389 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kamido, H.,;Matsuzawa, Y.,;Kita, T.;Tarui, S.: "Lipid composition of platelets from patients with atheroscleorsis: Effect of purified eicosapentaenoic acid ethyl ester administration." Lipids. 23. 917-923 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yokode, M.,;Kita, T.,;Narumiya, S.;Kawai, C.: "Arachidonate metabolism during foam cell transformation of macrophages." Advances in Prostaglandin, Thromaboxane, and Leukotriene Research. 17. 229-232 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kita, T.,;Kumi, N.,;Tsujita, Y.,;Ito, T.,;Watanabe, Y.;Kawai, C.: "Induction of hepatic LDL receptors in heterozygous WHHL rabbits treated with CS-524 alone or CS-514 in combination with cholestyramine." Drugs Affecting Lipid Metabolism. 251-254 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kita,T.,;Yokode,M.,;Kume,N.,;Ishii,K.,;Nagano,Y.,;Mikami,A.,;Kita,M.,;Fujii,K.,;Kawai,C.,;Domae,N.,;Ishihara,H.,;Kimura,M.,;Itokawa,Y.: Jap.Circl.J.52. 99-104 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kita,T.,;Nagano,Y.,;Yokode,M.,;Ishii,K.,;Kume,N.,;Narumiya,S.,;Kawai,C.: Am.J.Cardiol.62. 13B-19B (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Wu,D-J,;Fujiwara,H.;Tanaka,M.;Onodera,T.;Matsuda,M.;Ishida,M.;Kawamura,A.;Takemura,G.;Fujiwara,T.;Nagano,Y.;Ishii,K.;Kita,T.;Kawai,C.;Hamashima,Y.: Jap.Circl.J.52. 327-340 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yokode,M.,;Kita,T.,;Arai,H.,;Kawai,C.,;Narumiya,S.,;Fujiwara,M.: Proc.Natl.Acad.Sci.U.S.A.85. 2344-2348 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ishi,K.,;Kita,T.,;Kume,N.,;Nagano,Y.,;Kawai,C: Biochim.Bhiophys.Acta.962. 387-389 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kamido,H.,;Matsuzawa,Y.,;Tarui,S.: Lipids.23. 917-923 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yokode,M.,;Kita,T.,;Narumiya,S.,;Kawai,C.: Advances in Prostaglandin,Thromaboxane,and Leukotriene Research. 17. 229-232 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kita,T.,;Kume,N.,;Tsujita,Y.,;Ito,T.,;Watanabe,Y.,;Kawai,C.: Drugs Affecting Lipid Metabolism. 251-254 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kita.T;Yokode.M;Kita.M;Fujii.K;Kawai.C: J AM Col Cardiol. 42A. (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] Kita.T;Ishii.K;Kume.N;Nagano.Y;Kawai.C: Circulation. 74. II-33 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] Kita.T;Yokode.M;Kume.N;Ishii.K;Nagano.Y;Mikami.A;Kita.M;Fujii.K;Kasai.C;Domae.N;Ishihara.H;Kimura.M;Itokawa.Y: Jap Circl J.

    • Related Report
      1987 Annual Research Report
  • [Publications] 北徹: 臨床栄養.

    • Related Report
      1987 Annual Research Report
  • [Publications] 河合忠一編;北徹: "心臓病学(動脈硬化の成因)" 朝倉書店, 645-662 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] 河合忠一編;北徹: "心臓病学(冠状動脈疾患)" 朝倉書店, 862-871 (1986)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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