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Prevention and Control of Laboratory Acquired Hemorrhagic Fever with Renal Syndrome (HFRS) in Animal Experimentation.

Research Project

Project/Area Number 62304057
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionOsaka University

Principal Investigator

YAMANOUCHI TAKAHISA  Research Institute for Microbial Diseases, Professor, 微生物病研究所, 教授 (40029765)

Co-Investigator(Kenkyū-buntansha) MIYAMOTO HIROYUKI  Wakayama Medical College, Professor, 教授 (90029778)
KIMURA MICHIO  Kansai College of Acupuncture Medecine, Professor, 教授 (50111745)
KURATA TAKESHI  National Institute of Health, Head of department, 部長 (50012779)
DOHMAE KAYOKO  Osaka University, Research Institute for Microbial Diseases, Instructor, 微生物病研究所, 助手 (80127266)
YAMANISI KOICHI  Osaka University, Research Institute for Microbial Diseases, Associate Professor, 微生物病研究所, 助教授 (10029811)
浜田 忠弥  新潟大学, 医学部, 教授 (40027313)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 1988: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1987: ¥4,000,000 (Direct Cost: ¥4,000,000)
KeywordsEpidemic Hemorrhagic Fever / Hemorrhagic Fever with Renal Syndrome (HFRS) / HFRS virus / Laboratory Animal / ラット
Research Abstract

In Japan, an outbreak of laboratory infection of HFRS was first made public in November, 1978. Since then, this research group was organized, and both epidemiological and virological studies have been undertaken. Retrospective survey revealed that this type of HFRS already occured early in the 1970's. Since then, 126 human cases of laboratory acquired HFRS have been recorded in 22 facilities of Japan. Seroepidemiological sutudies revealed that laboratory rats exhibites high IFA titers against HFRS or related viruses at locations where HFRS patients occured. Researchers contracted HFRS more frequently than laboratory animal technicians or caretakers, although a caretaker died of HFRS. Inhalation of HFRS virus contaminated air in the animal room is mainly cause of infection with this virus. Wound infection during animal experiments is another important foute of infection. Infection of laboratory rats can occur by transferring animals from contaminated to other facility. Supply of the rats from contaminated colonies is the important and actual causes of infection of rats in animal facilities. Tissue fragments or cells of transplantable animal tumors are potential source of spreading the HFRS virus. Eradication of HFRS virus from contaminated can be achieved best by elimination of all animals, especially when human HFRS is associated with an infected laboratory rats. In some facilities, small number of human and rat sera have a low IFA titers. The real means of these low IFA titers are still remained to be resolved in future. in 1981, a guide-line was issued by our research group and governmental officials for protection of this type HFRS. Since then numbers of the patient decreased. The last patient was recorded at the end of 1984. On these successive facts, we emphasize that the prevention and control of laboratory acquired HFRS depend upon the knowledge and understanding of this disease among the biomedical researchers.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (57 results)

All Other

All Publications (57 results)

  • [Publications] KAWAMATA J; YAMANOUCHI T.: LABORATORY ANIMOL SCIENSE. 37. 431-436 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] DANTS JR JR; OKUNO Y.ET AL.,: INTERVIROLOGY. 27. 161-165 (1887)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Van,Der.Green.G.Yamanishi,K.et al.: ACTA VIROL (Praha). VOL.31. 499-503 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Van.Der.Green.G; Beelaert.G; Hoofd.G; Leirs.H; Verhagen.R; Yamanishi.K; Tkacenko.E.A; Lvanov.A.P.,: ARCH VIROL. VOL.95,. (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Van.Der.Green.G; Beelaert.G; Yamanishi.K; Tkacenko.E.A.et al.: VOL.31. 180-184 (1978)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yamanishi,K; Tanishita,O; Tamura,M; Asada,H; Kondo,K.et al.: VACCINE. VOL.6. 278-282 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 山之内孝尚、堂前嘉代子: 微生物. 3. 37-49 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 西山弘一、奥野良信: 臨床検査. 31. 722-730 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 宮本久夫、森野吉晴 他: 感染症学雑誌. 61. 633-638 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 宮本久夫、森野吉晴 他: 感染症学雑誌. 61. 639-644 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] ASADA H; TAMURA M.ET AL.: J.Gen.Virol.68. 1961-1969 (1977)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] TAMURA M; ASADA H.ET AL.: ANTIVIRAL RESEARCH. 8. 171-178 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Asada,H; Tamura,M; Kondo,K.et al.: J GEN VIROL. VOL.69. 2179-2188 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 堂前嘉代子: 和歌山医学雑誌. 40巻. 1-13 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Asada,H; Balachandra,K.at al.: J.Gen.Viral.(1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 山西弘一: "腎症候性出血熱(腎症候性出血熱のウイルス学)" 医歯薬出版社, 241(45-68) (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 倉田毅: "腎症候性出血熱(腎症候性出血熱の病理)" 医歯薬出版社, 241(69-108) (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 山之内孝尚: "臨床検査マニュアル(腎症候性出血熱)" 文光堂, 712-722 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 山之内孝尚: "腎症候性出血熱(動物実験腎症候性出血熱の発生) 川俣順一" 医歯薬出版社,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kurata,T; Sata,T; Aoyama,Y.et al.: "Systemic deposition of viral antigens in the vascular endothalia of hemorrhagic fever with renal syndrom.in"Cellular,molecular and genetic approaches to immunodiagnosis and immuno" edited by Kano,K.,Mori,S.,Sugisaki,T.and Torisu,M.Univ.Tokyo Press,305-312 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yamanouchi,T.;Dohmae,K.: "Epidemic Hemorrhagic Fever" J. Microorganisms. 3. 37-49 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yamanishi,K.;Okuno,Y.: "Virus Examination of Hemorrhagic Fever with Renal Syndrome (Korean Hemorrhagic Fever)" Clinical Examination. 31. 722-730 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Miyamoto,H.,;Morino,Y.,et al.: "An Epidemiologic Study on Rats Associated with Outbreak of Hemorrhagic Fever with Renal Syndrome - Comparison with Antibodies for Two Virus Strain, Hantaan Virus 76-118 Strain and Newly Isolated WKM Strain -" Kansenshogaku zasshi. 61. 633-638 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Miyamoto,H.,;Morino,Y.,et al.: "An Epidemiologic Study on HFRS After SiX Years Surveillance - Comparison with Antibodies for Two Virus Strain, Hantaan Virus 76-118 Strain and WKM Strain in Members of College -" Kansenshogaku zasshi. 61. 639-644 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Asada,H.;Tamura,M.;Kondo,K.,et al: "Role of T Lymphocyte Subsets in Protection and Recovery from Hantaan virus Infection in Mice." J.GEN VIROL. 68,. 1961-1969 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kawamata,J.;Yamanouchi,T.;Dohmae,K.et al.: "Contorol of Laboratory Acquired Hemorragic Fever with Renal Syndrome(HFRS) in Japan" LAB.ANIM SCI. 37,. 431-436 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] DANTAS JR JR; OKUNO Y,.ET AL.,: "VIRUSES OF HEMORRHAGIC FEVER WITH TENAL SYNDROME(HFRS) GROUPED BY IMUNO PRECIPITATION AND HEMAGGLUTINATION INHIBITION" INTERVIROLOGY. 27. 161-165 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Van, Der.Groen.G.;Yamanishi,K.,et al.: "Characterization of Hantaviruses Using Monoclonal Antibodies." ACTA VIROL (Praha). 31,. (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Van.Der.Green.G,;Beelaert.G,;Yamanishi.K,;Tkacenko.E.A.,et al: "Detection of Hantaviruses with RNA Probes Generated from Recombinant DNA" ARCH VIROL. 95,. (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] van.Der.Green.G,;Beelaert.G,Yamanishi.K,Tkacenko.E.A.,: "PARTIAL CHARACTERIZATION OF A HANTAVIRUS ISOLATED FROM A CLETHRIONOMYS GLAREOLUS CAPTURED IN BELGIUM." ACTA VIROL (PRAHA). 31. 180-184 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yamanishi,K.;Tanishita,O.,et al: "Development of Inactivated Vaccine Against Virus Causing Haemorrhagic Fever with Renal Syndrome." VACCINE. 6,. 278-282 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Asada,H.;Tamura,M.;Kondo,K.,et al: "Cell-Mediated Immunity to Virus Causing Haemorrhagic Fever with Renal Syndrome: Generation of Cytotoxic T Lymphocytes." J GEN VIROL. 69. 2179-2188 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Dohmae,K.: "Comparative Studies on the Pathogenesis of Hemorrhagic Fever with Renal Syndrome (HFRS) Virus in Newborn Mice and Rats" J. Wakayama Med. Soc.40. 1-13 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Asada,H.;Balachandra,K.,et al: "Cross-reactive Immunity among Different Serotypes of Virus Causing Haemorrhagic Fever with Renal Syndrom" J. Gen.Viral.(in press). (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tamura,M.;Asada,H.;Kondo,K.et al: "Effects of Human and Murine Interferons Against Hemorrhagic Fever with Renal Syndrome(HFRS) Virus (Hantaan Virus)" ANTIVIAL RES.8. 171-178 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yamanouchi, Takahisa: Hemorrhagic Fever with Renal Syndrome (Clinical Examination Manual). Bunkodo, 1595 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yamanouchi, Takahasa: Hemorrhagic Fever with Ranal Syndrome (Laboratory Type Infection of HFRS in Animal Experimentation). Ishiyaku shuppan, 241 9-43 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yamanishi, Koichi.: Hemorrhagic Fever with Renal Syndrome (Virology of HFRS). Ishiyaku shuppan, 241 45-48 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kurasta, Takeshi.: Hemorrhagic Fever with Renal Syndrome (Pathology of HFRS). Ishiyaku shuppan, 241 69-108 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kurata,T.;Sata,T.;Aoyama,Y.,et al.: Systemic deposition of viral antigens in the vascular endothalia of hemorrhagic fever with renal syndrom. In "Cellular, moecular and genetic approaches to immunodiagnosis and immunopathology". Univ. Tokyo Press,305-312 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yamanishi,K.;Tanishita,O.;Tamura,M.;Asada,H.;Kondo,K.: VACCINE. VOL.6,. 278-282 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Asada,H.;Tamura,M.;Kondo,K.: J.Gen.Virol.VOL.69,. 2179-2188 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 堂前嘉代子: 和歌山医学雑誌. 40. 1-13 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Asada,H.;Balachandra,K.: J.Gen.Virol.(1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 山之内孝尚: "臨床検査マニュアル・腎症候性出血熱" (712-722)1595 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 山之内孝尚;堂前嘉代子: 微生物. 3. 37-49 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 山西弘一;奥野良信: 臨床検査. 31. 722-730 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 宮本久夫;森野吉晴他: 感染症学雑誌. 60. 633-638 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 宮本久夫;森野吉晴他: 感染症学雑誌. 60. 639-644 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] ASADA.H;TAMURA.M;ETAL: JOUNAL GENERAL VIROLOGY. 68. 1961-1969 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] TAMURA.M;ASADA.H;ETAL: ANTIVIRAL RESEARCH. 8. (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] KAWAMATA.J;YAMANOUCHI.T;ETAL: LABORATORY ANIMOL SCIENSE. 37. 431-436 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] DANTAS JR JR;OKUNO Y.ETAL: INTERVIROLOGY. 27. (161-165)

    • Related Report
      1987 Annual Research Report
  • [Publications] 三輪谷俊夫;山之内孝尚: "臨床検査マニュアル(腎症候性出血熱)" 文光堂, 1595 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] 川俣順一編;山之内孝尚: "腎症候性出血熱(動物実験に伴う腎症候性出血熱の発生)" 歯薬出版社, 241(9-43) (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 川俣順一編;山西弘一: "腎症候性出血熱(腎症候性出血熱のウイルス学)" 医歯薬出版社, 241(45-68) (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 川俣順一編;倉田毅: "腎症候性出血熱(腎症候性出血熱の病理)" 医歯薬出版社, 241(69-108) (1987)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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