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The Study of Higher Order Structure of Biologically Active Macromolecules by Means of High-Resolution NMR

Research Project

Project/Area Number 62430019
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field 高分子物性
Research InstitutionTokyo Institute of Technology

Principal Investigator

CHUJO Riichiro  Tokyo Inst. Technol., Faculty of Eng., Prof., 工学部, 教授 (60016285)

Co-Investigator(Kenkyū-buntansha) AIZAWA Masuo  Tokyo Inst. Technol., Faculty of Eng., Prof., 工学部, 教授 (00016742)
NAKAHAMA Seiichi  Tokyo Inst. Technol., Faculty of Eng., Prof., 工学部, 教授 (90016410)
KOMIYAMA Jiro  Tokyo Inst. Technol., Faculty of Eng., Prof., 工学部, 教授 (60016574)
ABE Akihiro  Tokyo Inst. Technol., Faculty of Eng., Prof., 工学部, 教授 (50114848)
TODA Fujio  Tokyo Inst. Technol., Faculty of Eng., Prof., 工学部, 教授 (80011021)
Project Period (FY) 1987 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥38,200,000 (Direct Cost: ¥38,200,000)
Fiscal Year 1989: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1988: ¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 1987: ¥24,500,000 (Direct Cost: ¥24,500,000)
KeywordsHigh-resolution NMR / Higher-order structure of macromolecules / Protein / Polypeptide / Enzyme / Cyclodextrin / Glycoprotein / Artificial Enzyme / ^1HーNMR / ^<13>CーNMR / ^2HーNMR / イオノホア / コンホメーション / 水素結合 / 高次構造 / 高分子 / ^1HーNMMR / ペプチド / 遺伝子
Research Abstract

The biologically active macromolecules take a variety of higher-order structures according to the circumstances. This research project is being aimed to establish the higher-order structure of biologically active macromolecules in solutions and in solid states by means of high-resolution NMR spectroscopy. This project was carried out for three years from 1987 to 1989 on the three main research subjects,(1)glycoproteins,(2)enzymes and artificial enzymes, and (3)protein models. In the first subject, conformations and interaction between the sugar and peptide moieties were investigated for several O-glycosylated threonine containing oligopeptides which were models of antifreeze glycoprotein(Chujo & Inoue). In the second subject, enzyme-like activity of artificial enzyme, that is, histamine-modified cyclodextrin(Toda), and the role of branch in the molecular-inclusion function of branched cyclodextrins(Yamamoto) were investigated on the basis of structural information obtained from NMR. A hybrid protein between metapyrocatechase and binding protein A was produced by recombinant DNA techniques,and applicability of expressed fusion protein for enzyme immunoassay was investigated(Aizawa). In the last subject, the role of side-chain/side-chain interaction in the stabilization of higher-order structure of poly (gamma-benzyl glutamate)(Abe) and the effect of counterions on the structure of polyglutamate in solution(Komiyama) were investigated. The structure of potassium salt of carboxylic polyether, which is the model of natural ionophore,was studied in aqueous solution(Nakahama). The higher order structures or polypeptides and tropomyosine were also investigated in the solid state as well as in solution(Ando).

Report

(4 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report

Research Products

(98 results)

All Other

All Publications (98 results)

  • [Publications] Nobuyoshi J.Maeji: "Conformation-Determining Role for the N-Acetyl Group in the O-Glycosidic Linkage,α-GalNAc-Thr" Biopolymers. 26. 1753-1767 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hiroshi Ikeda: "Catalytic Properties of Dimethyl- -Cyclodextrin Bearing Imidazolylethyl Group.pH Dependence and Regioselectivity of the Hydrolysis of Nitrophenyl Acetates" Tetrahedron Letters. 29. 311-312 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Toshimasa Yamazaki: "Conformational Studies of N-Acetyl-N'-Methylamide Derivatives of α-Aminobutyric Acid,Norvaline,and Valine.I.Prefered Conformations in Solution as Studied by ^1H-NMR Spectroscopy" Biopolymers. 27. 969-984 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Akihiro Abe: "Conformational Studies of N-Acetyl-N'-Methylamide Derivatives of α-Aminobutyric Acid,Norvaline,and Valine.II.Experimental Results" Biopolymers. 27. 985-999 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Mitsuru Sato: "Hydration of Sodium and Caesium Salts of Poly(Acrylic Acid)in Aqueous Salt Solution" Polymer Commun.29. 49-51 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Mitsuru Sato: "A New Model of Counterion Condensation in Polyelectrite Solutions.II.Theoretical Predictions of Competitive Condensation between Counterions of Different Valences" Biophysical Chem.31. 209-215 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hitoshi Kuboniwa: "Crystal Structure of Potassium Salt of Synthetic Carboxylic Ionophore" Chemistry Letters. 923-926 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kazuo Yamaguchi: "Studies on Synthetic Ionophores VI.Synthesis of Polyether Carboxylic Acids and THeir Use as Carriers for Alkali Metal Ion Transport through Liquid Membrane" Bull.Chem.Soc.Japan. 61. 2047-2054 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shinji Ando: "Intermolecular Hydrogen-Bonding Effect on ^<13>C NMR Chemical Shifts of Glycine Residue Carbonyl Carbons of Peptides in the Solid State" J.Am.Chem.Soc.110. 3380-3386 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takeshi Yamanobe: "Conformational and Dynamic Aspects of Poly(γ-n-octadecyl L-glutamate)in the Solid State and Liquid-Crystalline state as Studied by Variable-Temperature ^<13>C CP/MAS NMR Spectroscopy" Macromolecules. 21. 48-50 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yasuhiko Yamamoto: "^1H-Nuclear Magnetic Resonance Study of 6-O-α-D-Glucopyranosyl α-Cyclodextrin/para-Nitrophenol Inclusion Complex" Chem.Letters. 495-498 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yasuhiko Yamamoto: "Determination of the Host-Guest Geometry in the Inclusion Complexes of Cyclomalto-Oligosaccharides with p-Nitrophenol in Solution" Carbohydrate Research. 182. 41-52 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Mitsuhiko Onda: "^1H-NMR Study of Intramolecular-Hydrogen Bonding Interaction in Cyclodextrins and Their Di-O-Methylated Derivatives" Bull.Chem.Soc.Japan. 61. 4015-4021 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yoshimasa Mimura: "NMR Study on Conformation of Ac-Thr(α-GalNAc)-Ala-Ala-OMe as a Model for Mucin Type Glycoprotein" Int.J.Peptide & Protein Research. 34. 363-368 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yoshimasa Mimura: "NMR Study on Interaction between Sugar and Peptide Moieties in Mucin Type Model Glycopeptides" Rep.Prog.Polym.Phys.Japan. 32. 503-506 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hiroshi Ishii: "Synthesis and Conformational Analysis of Aib-Containing Peptide Modelling for N-Glycosylation Site in N-Glycoprotein" Int.J.Biol.Macromole.11. 329-334 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hiroshi Ikeda: "Artificial Hydrlase Using Modified Dimethyl-α-Cyclodextrin" J.Inclusion Phenomena. 7. 117-124 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Akihiro Abe: "Deuterium NMR Analysis of Poly(γ-benzyl-L-glutamate)in the Lyotropic Liquid-Crystalline State: Orientational Order of the α-Helical Backbone and Conformation of the Pendant Side Chain" Macromolecules. 22. 2138-2145 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Akihiro Abe: "Orientational Order of α-Helical Poly(γ-benzyl glutamate)in the Lyotropic Liquid-Crystalline State.Comparison of Theory with Experiments" Macromolecules. 22. 2145-2149 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Toshimasa Yamazaki: "Conformational Characteristics of Polyglutamic Acids Esters:Persistence of Orientational Correlation Along the Side-Chain Flanking the α-Helical Backbone" Biopolymers. 28. 1959-1967 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Soichi Yabuki: "Electro-Conductive Enzyme Membrane" J.Chem.Soc.,Chem.Commun.945-946 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Eiri Kobatake: "Application of a Fusion Protein,Metapyrocatechase/Protein A,to an Enzyme Immunoassay" Anal.Biochem.(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shinji Ando: "Conformational Characterization of Glycine Residues Incorporated into Some Homopolypeptides by Solid State ^<13>C NMR Spectroscopy II." J.Molecular Structure. 192. 153-161 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Satoru Tsuji: "The ^<13>C-NMR Chemical Shift and the Higher Order Structure of L-Alanine Residues in Tropomyosine in the Solid State and in Solution" J.Molecular Structure. 196. 317-325 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shinji Ando: "A Conformational Study of Oligopeptides Containing Gly-Pro Sequence in the Solid State by ^<13>C CP/MAS NMR" J.Molecular Structure. 212. 123-135 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M.Okabe: "Conformational Behavior of Poly(β-Aspartate)with n-Alkyl Side Chains in the Solid State as Studied by ^<13>C-CP/MAS NMR Spectroscopy" J.Molecular Structure. 213. 213-220 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yasuhiko Yamamoto: "NMR Studies of Cyclodextrin Inclusion Complex" J.Carbohydrate Chemistry. 8. 29-46 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yoshihiro Kanda: "High-Resolution Nuclear Magnetic Resonance Study of 6-O-α-D-Glucopyranosyl-α-Cyclodextrin-para-Nitrophenol Inclusion Complex in Aqueous Solution" Bull.Chem.Soc.Japan. 62. 2002-2008 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yoshio Inoue: "Elucidation of the Host-Guest Geometrical Relationship in a Branched Cyclomaltohexaose Inclusion-Complex by Measurements of Intermolecular Nuclear Overhauser Effects in the Rotating-Frame" Carbohydrate Chemistry. 194. C8-13 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] N. J. Maeji, Y. Inoue, and R. Chujo: "Conformation Determining Role for the N-Acetyl Group in the O-Glycosidic Linkage, alpha-GalNAc-Thr" Biopolymer. 26. 1753-1767 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Mimura, Y. Inoue, N. J. Maeji, and R. Chujo: "NMR Study on Study on Conformation of Ac-Thr( alpha-GalNAc) -Ala-Ala-OMe as a Model for Mucin Type Glycoprotein" Int. J. Peptide Protein Res. 34, 363-368(1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Mimura, Y. Yamamoto, Y. Inoue, and R. Chujo: "NMR Study on Interaction between Sugar and Peptide Moieties in Mucin Type Model Glycopeptides" Rep. Prog. Polym. Phys. Jpn. 32, 503-506(1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] H. Ishii, O. Nadaoka, Y. Mimura, Y. Inoue, and R. Chujo: "Synthesis and Conformational Analysis of Aib-Containing Peptide Modelling for N-Glycosylation Site in N-Glycoprotein" Int. J. Biol. Macromol., 11, 329-334(1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] H. Ikeda, R. Kojin, C.-J. Yoon, T. Ikeda, and F. Toda: "Catalytic Properties of Dimethyl-beta-Cyclodextrin Bearing Imidazolylethyl Group. pH Dependence and Regioselectivity of the Hydrolysis of Nitrophenyl Acetates" Tetrahedron Letters, 29, 311-312(1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] H. Ikeda, R. Kojin, C.-J. Yoon, T. Ikeda, and F. Toda: "Artificial Hydrolase Using Modified Dimethyl-beta-cyclodextrin" J. Inclusion Phenomena, 7, 117-124(1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Yamazaki and A. Abe: "Conformational Studies of N-Acetyl-N'-Methylamide Derivatives of alpha-Aminobutyric Acid, Norvaline, and Valine. I. Preferred Conformations in Solution as Studied by 'H-NMR Spectroscopy" Biopolymers, 27, 969-984(1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] A. Abe and T. Yamazaki: "Conformational Studies of N-Acetyl-N'-Methylamide Derivatives of alpha-Aminobutyric Acid, Norvaline, and Valine. II. Conformational Energy Calculations and Comparison with Experimental Results" Biopolymers, 27, 985-999(1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] A. Abe and T. Yamazaki: "Orientational Order of alpha-Helical Poly(gamma-benzyl glutamate) in the Lyotropic Liquid-Crystalline State. Comparison of Theory with Experiments" Macromolecules 22, 2145-2149(1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Yamazaki, A. Abe, H. Ono, and H. Toriumi: "Conformational Characteristics of Polyglutamic Acid Esters:Persistence of Orientational Correlation Along the Side Chain Flanking the alpha-Helical Backbone" Biopolymers, 28, 1959-1967(1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M. Sato, M. Hayashi, J. Komiyama, and T. Iijima: "Hydration of Sodium and Caesium Salts of Poly(Acrylic Acid) in Aqueous Salt Solutions" Polymer Commun., 29, 49-51(1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M. Sato, T. Kawashima, and J. Komiyama: "A New Model of Counterion Condensation in a Polyelectrolyte Solutions. II. Theoretical Predictions of Competitive Condensation between Counterions of Different Valences" Biophys. Chem., 31, 209-215(1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] H. Kuboniwa, K. Yamaguchi, S. Nakahama, K. Hori, and Y. Ohashi: "Crystal Structure of Potassium Salt of Synthetic Carboxylic Ionophore" Chemistry Letters, 923-926(1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K. Yamaguchi, S. Negi, S. Kozakai, R. Nagano, H. Kuboniwa, A. Hirao, S. Nakahama, and N. Yamazaki: "Studies on Synthetic Ionophores. VI. Synthesis of Polyether Carboxylic Acids and Their Use as Carriers for Alkali Metal Ion Transport Through Liquid Membrane" Bull. Chem. Soc., Jpn., 61, 2047-2054(1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] S. Yabuki, H. Shinohara, and M. Aizawa: "Electro-Conductive Enzyme Membrane" J. Chem. Soc., Chem. Commun 945-946(1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] E. Kobatake, Y. Nishimori, Y. Ikariyama, M. Aizawa, and S. Kato: "Application of a Fusion Protein, Metapyrocatechase/Protein A, to an Enzyme Immunoaasay" Anal. Biochem.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] S. Ando, I. Ando, A. Shoji, and T. Ozaki: "Intermolecular Hydrogen-Bonding Effect on ^<13>C NMR Chemical Shifts of Glycine Residue Carbonyl Carbons of Peptides in the Solid State" J. Am. Chem. Soc., 110, 3380-3386(1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Yamanobe, M. Tsukahara, T. Komoto, J. Watanabe, I. Ando, I. Uematsu, K. Deguchi, T. Fujito, and M. Imanari: "Conformation and Dynamic Aspects of Poly(gamma-n-octadecyl L-glutamate) in the Solid State and Liquid-Crystalline State as Studied by Variable-Temperature ^<13>C CP/MAS NMR Spectroscopy" Macromolecules, 21, 48-50(1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] S. Ando, I. Ando, A. Shoji, and T. Ozaki: "Conformational Characterization of Glycine Residues Incorporated into Some Homopolypeptides by Solid State ^<13>C NMR Spectroscopy. II." J. Molecular Structure, 192, 153-161(1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] S. Tuji and I. Ando: "The C-NMR Chemical Shift and the Higher Order Structure of L-Alanine Residues in Tropomyosine in the Solid State and in Solution" J. Molecular Structure 196, 317-325(1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] S. Ando, K. Matsumoto, I. Ando, A. Shoji, and T. Ozaki: "A Conformational Study of Oligopeptides Containing Gly-Pro Sequence in the Solid State by ^<13>C CP/MAS NMR" J. Molecular Structure, 212, 123-135(1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M. Okabe, T. Yamanobe, T. Komoto, J. Watanabe, I. Ando, and I. Uematsu: "Conformational Behavior of Poly(beta-Aspartate) with n-Alkyl Side Chains in the Solid State as Studied by ^<13>C-CP/MAS-NMR Spectroscopy" J. Molecular Structure 213, 213-220(1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Yamamoto, Y. Kanda, Y. Inoue, R. Chujo, and S. Kobayashi: "^1H-Nuclear Magnetic Resonance Study of 6-O- alpha-D-Glucopyranosyl alpha-Cyclodextrin/para-Nitrophenol Inclusion Complex" Chemistry Letters, 495-498(1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Yamamoto, M. Onda, Y. Takahashi, Y. Inoue, and R. Chujo: "Determination of the Host-Guest Geometry in the Inclusion Complexes of Cyclomaltooligosaccharides with p-Nitrophenol in Solution" Carbohydr. Res., 182, 41-52(1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M. Onda, Y. Yamamoto, Y. Inoue, and R. Chujo: "^1H-NMR Study of Intramolecular-Hydrogen Bonding Interaction in Cyclodextrins and Their Di-O-Methylated Derivatives" Bull. Chem. Soc. Jpn., 61, 4015-4021(1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Yamamoto and Y. Inoue: "NMR Studies of Cyclodextrin Inclusion Complex" J. Carbohydrate Chem., 8, 29-46(1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Kanda, Y. Yamamoto, Y. Inoue, R. Chujo, and S. Kobayashi: "High-Resolution Nuclear Magnetic Resonance Study of 6-O-alpha-D-Glucopyranosyl- alpha-Cyclodextrin-Para-Nitrophenol Inclusion Complex in Aqueous Solution" Bull. Chem. Soc. Jpn., 62, 2002-2008(1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Inoue, Y. Kanda, Y. Yamamoto, R. Chujo, and S. Kobayashi: "Elucidation of the Host-Guest Geometrical Relationship in a Branched Cyclomaltohexaose Inclusion-Complex by Measurements of Intermolecular Nuclear Overhauser Effects in the Rotating-Frame" Carbohydr. Res., 194, C8-13(1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ishii Hiroshi: "Synthesis and Conformational Analysis of Aib-Containing Peptide Modelling for N-Glycosylation Site in N-Glycoprotein" International J.Biological Macromolecules. 11. 329-334 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Mimura Yoshimasa: "NMR Study on Conformation of Ac-Thr(alpha-GalNAc)-Ala-Ala-OMe as a Model for Mucin Type Glycoprotein" International J.Peptide&Protein Research. 34. 363-368 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Mimura Yoshimasa: "NMR Study on Interaction between Sugar and Peptide Moieties in Mucin Type Model Glycopeptides" Rep.Prog.Polym.Phys.Japan. 32. 503-506 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ikeda Hiroshi: "Artificial Hydrolase Using Modified Dimethyl-B-Cyclodextrin" J.Inclusion Phenomena. 7. 117-124 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Abe Akihiro: "Deuterium NMR Analysis of Poly(gammaーbenzylーLーglutamate)in the Lyotropic LiquidーCrystalline State:Orientational Order of the alphaーHelical Backbone and Conformation of the Pendant Side Chain" Macromolecules. 22. 2138-2145 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Abe Akihiro: "Orientational Order of alphaーHelical Poly(gammaーbenzyl glutamate)in the Lyotropic LiquidーCrystalline State.Comparison of Theory with Experiments." Macromolecules. 22. 2145-2149 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Yamazaki Toshimasa: "Conformational Characteristics of Polyglutamic Acid Esters:Persistence of Orientational Correlation Along the Side Chain Flanking the alphaーHelical Backbone" Biopolymers. 28. 1959-1967 (1989)

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  • [Publications] Sato Mitsuru: "A New Model of Counterion Condensation in Polyelectrolyte Solutions:II.Theoretical Predictions of Competitive Condensation between Counterions of Different Valences" Biophysical Chem.31. 209-215 (1988)

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  • [Publications] Yamaguchi Kazuo: "Studies on Synthetic Ionophores.VI.Synthesis of Polyether Carboxylic Acids and Their Use as Carriers for Alkali Metal Ion Transport Through Liquid Membrane" Bull.Chem.Soc.Japan. 61. 2047-2054 (1988)

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  • [Publications] Yabuki Soichi: "ElectroーConductive Enzyme Membrane" J.Chem.Soc.,Chem.Commun.945-946 (1989)

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  • [Publications] E.Kobatake: "Application of a Fusion Protein,Metapyrocatechase/Protein A,to an Enzyme Immunoassay" Anal.Biochem.(印刷中).

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  • [Publications] Ando Shinji: "Conformational Characterization of Glycine Residues Incorporated into Some Homopolypeptides by Solid State ^<13>C NMR Spectroscopy" J.Molecular Structure. 192. 153-161 (1989)

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  • [Publications] Tuji Satoru: "The ^<13>CーNMR Chemical Shift and the Higher Order Structure of LーAlanine Residues in Tropomyosine in the Solid State and in Solution" J.Molecular Structure. 196. 317-325 (1989)

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  • [Publications] Ando Shinji: "A Conformational Study of Oligopeptides Containing GlyーPro Sequence in the Solid State by ^<13>C CP/MAS NMR" J.Molecular Structure. 212. 123-135 (1989)

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  • [Publications] Yamamoto Yasuhiko: "NMR Studies of Cyclodextrin Inclusion Complex" J.Carbohydrate Chemistry. 8. 29-46 (1989)

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  • [Publications] Kanda Yoshihiro: "HighーResolution Nuclear Magnetic Resonance Study of 6ーOー ーDーGlucopyranosylー ー CyclodextrinーparaーNitrophenol Inclusion Complex in Aqueous Solution" Bull.Chem.Soc.Japan. 62. 2002-2008 (1989)

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  • [Publications] Inoue Yoshio: "Elucidation of the HostーGuest Geometrical Relationship in a Branched Cyclomaltohexaose InclusionーComplex by Measurements of Intermolecular Nuclear Overhauser Effects in the Rotating Frame" Carbohydrate Research. 194. C8-13 (1989)

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  • [Publications] Hiroshi Ishii: Polymer Journal. 20. 65-72 (1988)

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  • [Publications] Yoshio Inoue: International J.of Peptide & Protein Research.

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  • [Publications] Yasuhiko Yamamoto: Chemistry Lett.495-498 (1988)

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  • [Publications] Yasuhiko Yamamoto: Carbohydrate Research. 182. 41-52 (1988)

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  • [Publications] Mitsuhiko Onda: Bull.Chem.Soc.Japan. 61. 4015-4021 (1988)

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      1988 Annual Research Report
  • [Publications] Akihiro Abe: Macromolecules.

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  • [Publications] Toshimasa Yamazaki: Biopolymers.

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      1988 Annual Research Report
  • [Publications] Mitsuru Satoh: Polymer. 29. 49-51 (1988)

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  • [Publications] Mitsuru Satoh: Biophys.Chemistry. 31. 209-215 (1988)

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  • [Publications] Hitoshi Kuboniwa: Chemistry Lett.923-926 (1988)

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  • [Publications] Kazuo Yamaguchi: Bull.Chem.Soc.Japan. 61. 2047-2054 (1988)

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  • [Publications] Shinji Ando: J.American Chemical Society. 110. 3380-3386 (1988)

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  • [Publications] Nobuyoshi Joe Maeji: Carbohydr. Res.162. C4-C8 (1987)

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  • [Publications] Nobuyoshi Joe Maeji: Biopolymers. 26. 1753-1767 (1987)

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  • [Publications] Yasuhiko Yamamoto: Carbohydr. Res.166. 156-161 (1987)

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  • [Publications] Yoshio Inoue: Bull. Chem. Soc. Japan. 60. 2539-2545 (1987)

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  • [Publications] Hiroshi Ikeda: Chem. Lett.1495-1498 (1987)

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  • [Publications] Chul Joong Yoon: J. Inclusion Phenomena. 5. 85-91 (1987)

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  • [Publications] Toshimasa Yamazaki: Biopolymers.

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  • [Publications] Akihiro Abe: Biopolymers.

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  • [Publications] Mitsuru Satoh: Polymer Communications. 28. 71-73 (1987)

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  • [Publications] Kazuo Yamaguchi: Bull. Chem. Soc. Japan.

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  • [Publications] Shin Ando: J. Am. Chem. Soc.

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  • [Publications] Yasuhiko Yamamoto: Carbohydr. Res.170. 229-234 (1987)

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Published: 1987-03-31   Modified: 2016-04-21  

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