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Fever and Host Defense

Research Project

Project/Area Number 62440025
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field 環境生理学(含体力医学・栄養生理学)
Research InstitutionYamaguchi University

Principal Investigator

MURAKAMI Naotoshi  Yamaguchi Univ. Sch. of Med., Professor, 医学部, 教授 (90040518)

Co-Investigator(Kenkyū-buntansha) WATANABE Tatsuo  Yamaguchi Univ. Sch. of Med., Instructor, 医学部, 助手 (60182929)
SAKATA Yoshiyuki  Yamaguchi Univ. Sch. of Med., Instructor, 医学部, 助手 (10034927)
MORIMOTO Akio  Yamaguchi Univ. Sch. of Med., Associate Professor, 医学部, 助教授 (70127794)
Project Period (FY) 1987 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥19,400,000 (Direct Cost: ¥19,400,000)
Fiscal Year 1990: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1989: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1988: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1987: ¥7,800,000 (Direct Cost: ¥7,800,000)
KeywordsFever / Pyrogen / Non-specific host defense / Hybridization / Unanesthetized animal / Electrophysiological experiment / Pathogenesis of fever / 無拘束動物 / Telemetory system / ストレス性高体温 / プロスタグランジン / ACTH / CRF / ノルアドレナリン / 急性相反応 / OVLT / インタ-ロイキン1 / 家兎 / ラット / 長期運動鍛練 / Interleukinー1 / 発熱 / 腫瘍壊死因子 / インターフェロン / Interleukin-l / EP / サイトカイン / 神経系 / 免疫系 / 下垂体・副腎系 / プロスタグランディン
Research Abstract

According to progress of cytokine studies, it has been reported that many cytokines have intrinsically pyrogenic property and are believed to be contained in a substance what we called generally as endogenous pyrogen so far. In order to investigate on central mechanism of febrile response to a variety of pyrogenic cytokines and its relation to development of non-specific host defense, acutephase response, three different levels of research, as follows, were used.
1) Histo in-situ hybridization method,
2) Fever experiments on unanesthetized experimental animals,
3) Electrophysiological experiments on anesthetized animals,
Among three levels, fever experiments on unanesthetized animals has provided much evidence which has clarified the central mechanism of febrile response evoked by several kinds of cytokine and has presented the different pattern of non-specific host defense. However, little evidence has been obtained through the histo in-situ hybridization method and the electrophysiological experiments on anesthetized animals. Further more experiments may be needed to know the details of these problems.

Report

(5 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • Research Products

    (141 results)

All Other

All Publications (141 results)

  • [Publications] Morimoto,A.,et al.: "Evidence for separate mechanisms of induction of biphasic fever inside and outside the blood brain barrier in rats" J.Physiol.383. 629-637 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Suppression of antipyretic response in rabbits by intraventricular protein synthesis inhibitor" Pflugers Arch.408. 414-416 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami,N.,et al.: "Sexーrelated differences in fever development of rats" AM.J.Physiol.252. R284-R289 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Fever induced in rabbits by intraventricular injection of rabbit and human serum albumin" J.Physiol.390. 137-144 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Watanabe,T.,et al.: "Effects of endogenous pyrogen and prostaglandin E_2 on hypothalamic neurons in rat brain slices" Can.J.Physiol.Pharmacol.65. 1382-1388 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami,N.,et al.: "Acute phase response induced by monoー and biphasic fever" Neuroscience Res.Suppl.5. S24 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 村上 悳: "インタ-ロイキン1,内因性発熱物質による発熱" 日本臨床. 45. 961-968 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 森本 昭生: "脳代謝活動からみた体温調節中枢神経機構の研究" 山口医学. 36. 139-143 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ono,T.,et al.: "Effects of endogenous pyrogen and prostaglandin E_2 on hypothalamic neurons in guinea pig brain slices" J.Appl.Physiol.63. 175-180 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Fever and acute phase response induced in rabbits by human recombinant interferonーγ" J.Physiol.391. 209-218 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Watanabe,T.,et al.: "Effect of PGE_2 on preoptic and anterior hypothalamic neurons using slice preparation" J.Appl.Physiol.63. 918-922 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Separate mechanisms inside and outside the bloodーbrain barrier inducing metabolic chages in febrile rabbits" J.Physiol.392. 637-649 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami,N.,et al.: "Pathophysiology of fever in patients of cerebral or subarachnoid hemorrhages" Man in stressful environments ー Thermal and work physiology. 169-180 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "The temperature selected by thermoregulatory behavior is affected by initial ambient temperature" Bull.Yamaguchi Med.Sch.34. 7-13 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Restraint induced stress elicits acuteーphase response in rabbits" Pflugers Arch.410. 554-556 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami,N.,et al.: "Changes in metabolic activity of the central nervous structures during hypodymic exposure (body suspention)" Proceedings of the Ninth Annual Meeting of the IUPS Commission on Gravitational Physiology.Supplement.The Physiologist. 31. S152-S153 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Ventromedial hypothalamus is highly sensitive to prostaglandin E_2 for producing fever in rabbits" J.Physiol.397. 259-268 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Multiple control of fever production in the central nervous system of rabbits" J.Physiol.397. 269-280 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Is the central arachidonic acid cascade system involved in the development of accuteーphase response in rabbits?" J.Physiol.397. 281-289 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Changes in hypothalamic temperature modulate the neuronal response of the ventral thalamus to skin warming in rats" J.Physiol.398. 97-108 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Pattern differences in experimental fevers induced by endotoxin,endogenous pyrogon,and prostaglandins" Am.J.Physiol.254. R633-R640 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami,N.: "Multiple control of fever production in the brain stem of rabbits" Neuroscience Res.Suppl.7. S68 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Effect of prostaglandin E_2 on thermoresponsive neurones in the preoptic and ventromedial hypothalamic regions of rats" J.Physiol.405. 713-725 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami,N.: "Analysis on pyrogenic action of recombinant tumor necrosis factor (rTNF)" Int.J.Biometeol.32. 222 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Leukocytosis induced by microinjection of endogenous pyrogen or interleukinー1 into the preoptic and anterior hypothalamus" Brain Res.475. 345-348 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami,N.,et al.: "Activation of ACTH release is mediated by the same molecule as the final mediator,PGE_2,of febrile response in rats" Brain Res.478. 171-174 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Characteristics of fever and acuteーphase response induced in rabbits by ILー1 and TNF" Am.J.Physiol.256. R35-R41 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 村上 悳: "発熱機構と自律神経" Clinical Neuroscience. 6. 64-65 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 村上 悳,他: "脳・血液関門を境にした発熱物質の作用機構" 炎症. 8. 305-309 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Possible involvement of prostaglandin E in development of ACTH response in rats induced by human recombinant interleukinー1" J.Physiol.411. 245-256 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sakata,Y.,et al.: "Responses of thalamic neurons in rats to skin cooling and hypothalamic temperature" Am.J.Physiol.256. R1293-R1298 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sakata,Y.,et al.: "Effect of intravascular of endogenous pyrogen or prostaglandin E_2 on neuronal activity of rat′s hypoーthalamus" Bull.Yamaguchi Medical Journal. 36. 1-8 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Brain regions involved in the development of acute phase responses accompanying fever in rabbits" J.Physiol.416. 645-657 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sakata,Y.,et al.: "Effect of preoptic/anterior hypothalamic temperature on activity of thalamic neurons in rats responding to skin temperature" Thermal Physiology ed.by Mercer,J.B.,Excerpta Medica,Amsterdam. 73-76 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami,N.: "A possible role of the central nervous system for induction of acute phase responses during fever" Int.J.Biometeorol.33. 202 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 村上 悳,他: "発熱時にみられる下垂体ー副腎系活動の賦活化機構" 炎症. 9. 289-294 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Watanbe,T.,et al.: "ACTH response induced by interleukinー1 is mediated by CRF secretion stimulated by hypothalamic PGE" Experientia. 46. 481-484 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Metabolic activation of the fetal rat brain" Meuroscience Letters. 111. 34-38 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sugiura,T.,et al.: "Separation of myosin heavy chain isoforms in rat skeletal muscles by gradient sodium dodecyl sulfateーpolycrylamide gel electrophoresis" Biomedical Res.11. 87-91 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sakata,Y.,et al.: "Response of thermoresponsive neurons of rat′s hypoーthalamus during intracarotid infusion of prostagladinE_2" Brain Res.Bull.24. 529-532 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] ImaiーMatsumura,K.,et al.: "Maternal thermal stimulation changes metabolic activity in fetal hypothalamus" Brain Res.513. 295-298 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] ImaiーMatsumura,K.,et al.: "Suppression of coldーinduced thermogenesis in fullーterm pregnant rats" J.Physiol.425. 271-281 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Leucocytosis induced in rabbits by intravenous or central,injection of granulocyte colony stimulating factor" J.Physiol.426. 117-126 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto,A.,et al.: "Functional and structural differences in febrile mechanism between rabbits and rats" J.Physiol.427. 227-239 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Wada,M.,et al.: "Effect of physical trainig on febrile and acuteーphase responses induced in rats by bacterial endotoxin or interleukinー1" J.Physiol.430. 595-603 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami,N.,et al.: "Central action sites of interleukinー1β for inducing fever in rabbits" J.Physiol.428. 299-312 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 村上 悳: "発熱と生体防御" 自律神経. 27. 378-384 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 村上 悳: "新生理学大系,第22巻,エネルギ-代謝・体温調節の生理学 中山昭雄・入来正躬編" 医学書院, 286-296 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 村上 悳: "発熱と生体防御" 日本医事新報社, 1-207 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 村上 悳: "発熱症候群 入来正躬編" 文光堂, 20-31,106-118 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Evidence for separate mechanisms of induction of biphasic fever inside and outside the blood brain barrier in rats." J. Physiol.383. 629-637 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Suppression of antipyretic response in rabbits by intraventricular protein synthesis inhibitor." Pflugers Arch.408. 414-416 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami, N., et al.: "Sex-related differences in fever development of rats." Am. J. Physiol.252. 284-289 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Fever induced in rabbits by intraventricular injection of rabbit and human serum albumin." J. Physiol.390. 137-144 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Watanabe, T., et al.: "Effects of endogenous pyrogen and prostaglandin E_2 on hypothalamic neurons in brain slices." Can. J. Physiol. Pharmacol.65. 1382-1388 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami, N., et al.: "Acute phase response induced by mono- and biphasic fever." Neuroscience Res.Suppl. 5. S24 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami, N.: "Interleukin-l, fever induced by endogenous pyrogen." Jap. J. Clin. Med.45. 961-968 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A.: "Study on the central mechanism of thermoregulation, using [^<14>C]deoxyglucose technique." Yamaguchi Medical Journal. 36. 139-143 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ono, T. et al.: "Effects of endogenous pyrogen and prostaglandin E_2 on hypothalamic neurons in guinea pig brain slices." J. Appl. Physiol.63. 175-180 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Fever and acute phase response induced in rabbits by human recombinant interferon-gamma." J. Physiol.391. 209-218 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Watanabe, T., et al.: "Effect of PGE_2 on preoptic and anterior hypothalamic neurons using slice preparation." J. Appl. Physiol.63. 918-922 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Separate mechanisms inside and outside the blood-brain barrier inducing metabolic changes in febrile rabbits." J. Physiol.392. 637-649 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami, N., et al.: "Pathophysiology of fever in patients of cerebral or subarachnoid hemorrhages." Man in stressful environments. - Thermal and work physiology. 169-180 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "The temperature selected by thermoregulatory behavior is affected by initial ambient temperature." Bull. Yamaguchi Med. Sch.34. 7-13 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Restraint induced stress elicits acute-phase response in rabbits." Pflugers Arch.410. 554-556 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami, N., et al.: "Changes in metabolic activity of the central nervous structures during hypodynamic exposure (body suspension)." Proceedings of the Ninth Annual Meeting of the IUPS Commission on Gravitational Physiology.Supplement. The Physiologist, 31. S152-S153 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Ventromedial hypothalamus is highly sensitive to prostaglandin E_2 for producing fever in rabbits." J. Physiol.397. 259-268 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Multiple control of fever production in the central nervous system of rabbits." J. Physiol.397. 269-280 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Is the central arachidonic acid cascade system involved in the development of acute-phase response in rabbits?" J. Physiol.397. 281-289 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Changes in hypothalamic temperature modulate the neuronal response of the ventral thalamus to skin warming in rats." J. Physiol.398. 97-108 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Pattern differences in experimental fevers induced by endotoxin, endogenous pyrogen, and prostaglandins." Am. J. Physiol.254. R633-R640 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami, N.: "Multiple control of fever production in the brain stem of rabbits." Neuroscience Res.Suppl. 7. S68 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Effect of prostaglandin E_2 on thermoresponsive neurones in the preoptic and ventromedial hypothalamic regions of rats." J. Prysiol.405. 713-725 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami, N.: "Analysis on pyrogenic action of recombinant tumor necrosis factor (rTNF)." Int. J. Biometeol.32. 222 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Leukocytosis induced by microinjection of endogenous pyrogen or interleukin-l into the preoptic and anterior hypothalamus." Brain Res.475. 345-348 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami, N., et al.: "Activation of ACTH release is mediated by the same molecule as the final mediator, PGE_2, of febrile response in rats." Brain Res.478. 171-174 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Characteristics of fever and acute-phase response induced in rabbits by IL-l and TNF." Am. J. Physiol.256. R35-R41 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami, N.: "Febrile response and the autonomic nervous system." Clinical Neuroscience. 6. 64-65 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami, N., et al.: "Dual mechanisms of fever induction inside and outside the blood-brain barrier in rabbits." Jap. J. Inflammation. 8. 305-309 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Possible involvement of prostaglandin E in development of ACTH response in rats induced by human recombinant interleukin-l." J. Physiol.411. 245-256 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sakata, Y., et al.: "Responses of thalamic neurons in rats to skin cooling and hypothalamic temperature." Am. J. Physiol.256. R1293-R1298 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sakata, Y., et al.: "Effect of intravascular infusion of endogenous pyrogen or prostaglandin E_2 on neuronal activity of rat's hypothalamus." Bull. Yamaguchi Medical Journal. 36. 1-8 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Brain regions involved in the development of acute phase responses accompanying fever in rabbits." J. Physiol.416. 645-657 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sakata, Y., et al.: "Effect of preoptic/anterior hypothalamic temperature on activity of thalamic neurons in rats responding to skin temperature." Thermal Physiology ed. by Mercer, J. B.Excerpta Medica, Amsterdam. 73-76 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami, N.: "A possible role of the central nervous system for induction of acute phase responses during fever." Int. J. Biometeorol.33. 202 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami, N., et al.: "A possible role of prostaglandin in increase of plasma ACTH during febrile response." JaP. J. Inflammation. 9. 289-294 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Watanabe, T., et al.: "ACTH response induced by interleukin-l is mediated by CRF secretion stimulated by hypothalamic PGE." Experientia. 46. 481-484 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Metabolic activation of the fetal rat brain." Neuroscience Letters. 111. 34-38 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sugiura, T., et al.: "Separation of myosin heavy chain isoforms in rat skeletal muscles by gradient sodium dodecyl sulfate-polyacrylamide gel electrophoresis." Biomedical Res.11. 87-91 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sakata, Y., et al.: "Response of thermoresponsive neurons of rat's hypothalamus during intracarotid infusion of prostaglandin E_2." Brain Res. Bull.24. 529-532 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Imai-Matsumura, K., et al.: "Maternal thermal stimulation changes metabolic activity in fetal hypothalamus." Brain Res.513. 295-298 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Imai-Matsumura, K., et al.: "Suppression of cold-induced thermogenesis in full-term pregnant rats." J. Physiol.425. 271-281 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Leucocytosis induced in rabbits by intravenous or central injection of granulocyte colony stimulating factor." J. Physiol.426. 117-126 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Morimoto, A., et al.: "Functional and structural differences in febrile mechanism between rabbits and rats." J. Physiol.427. 227-239 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Wada, M., et al.: "Effect of physical training on febrile and acute-phase responses induced in rats by bacterial endotoxin or interleukin-l." J. Physiol.430. 595-603 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami, N., et al.: "Central action sites of interleukin-l beta for inducing fever in rabbits." J. Physiol.428. 299-312 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami, N.: "Fever and host defense." The Autonomic Nervous System. 27. 378-384 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami, N.: "Behavioral thermoregulation" The New Handbook of Physiology Vo1.22, Energy Metabolism and Thermoregulation. ed. by Nakayama, T. and Iriki, M.Igakuchoin Tokyo. 286-296 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami, N.: "Fever and host defense" Japan Medical Journal Pub. Co., Tokyo. 1-207 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Murakami, N.: "Pyrogen, Acute phase response" Fever Syndrom, ed. by Iriki, M.Bunkodo, Tokyo. 20-31, 106-118 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Watanabe,T.,et al.: "ACTH response induced by interleukinー1 is mediated by CRF secretion stimulated by hypothalamic PGE" Experientia. 46. 481-484 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Morimoto,A.,et al.: "Metabolic activation of the fetal rat brain" Neuroscience Letters. 111. 34-38 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Sugiura,T.,et al.: "Separation of myosin heavy chain isoforms in rat skeletal muscles by gradient sodium dodecyl sulfateーpolyacrylamide gel electrophoresis" Biomedical Res.11. 87-91 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Sakata,Y.,et al.: "Response of thermoresponsive neurons of rat's hypothalamus during intracarotid infusion of prostaglandin E_2" Brain Res.Bull.24. 529-532 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] ImaiーMatsumura,K.,et al.: "Maternal thermal stimulation changes metabolic activity in fetal hypothalamus" Brain Res.513. 295-298 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] ImaiーMatsumura,K.,et al.: "Suppression of coldーinduced thermogenesis in fullーterm pregnant rats" J.Physiol.425. 271-281 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Morimoto,A.,et al.: "Leucocytosis induced in rabbits by intravenous or central injection of granulocyte colony stimulating factor" J.Physiol.426. 117-126 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Morimoto,A.,et al.: "Functional and structural differences in febrile mechanism between rabbits and rats" J.Physiol.427. 227-239 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Wada,M.,et al.: "Effect of physical training on febrile and acuteーphase responses induced in rats by bacterial endotoxin or interleukinー1" J.Physiol.430. 595-603 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Murakami,N.,et al.: "Central action sites of interleukinー1β for inducing fever in rabbits" J.Physiol.428. 299-312 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 村上 悳: "発熱と生体防御" 自律神経. 27. 378-384 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Morimoto,A.: "Possible involvement of prostaglandin E in development of ACTH response in rats induced by human recombinant interleukin-1." J.Physiol.411. 245-256 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Sakata,Y.: "Responses of thalamic neurons in rats to skin cooling and hypothalamic temperature." Am.J.Physiol.256. R1293-R1298 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Sakata,Y.: "Effect of intravascular infusion of endogenous pyrogen or prostaglandin E_2 on neuronal activity of rat's hypothalamus." Bull.Yamaguchi Medical Journal. 36. 1-8 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Morimoto,A.: "Brain regions involved in the development of acute phase responses accompanying fever in rabbits." J.Physiol.416. 645-657 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Sakata,Y.: "Effect of preoptic/anterior hypothalamic temperature on activity of thalamic neurons in rats responding to skin temperature." Thermal physiology,ed.by Mercer J.B.,Excerpta Midica,Amsterdam. 73-76 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 村上悳: "発熱時にみられる下垂体ー副腎系活動の賦活化機構" 炎症. 9. 289-294 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 村上悳: "発熱症候群(分担)" 文光堂, 38 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Morimoto,A.: J.Physiol.397. 259-268 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Morimoto,A.: J.Physiol.397. 281-289 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Morimoto,A.: J.Physiol.397. 269-280 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Morimoto,A.: J.Physiol.398. 97-108 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Morimoto,A.: Am.J.Physiol.254. R633-R640 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Murakami,N.: Neuroscience Res.Suppl.7. s68 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Morimoto,A.: J.Physiol.405. 713-725 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Morimoto,A.: Brain Res.475. 345-348 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 村上悳: Clinical Neuroscience. 6(8). 64-65 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 村上悳: 炎症. 8(4). 305-309 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Murakami,N.: Int.J.Biometeol.32. 222 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 村上悳: "発熱と生体防御" 日本医事新報社, 1-215 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Murakami, N.: Am. J. Physiol.252. R284-R289 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Morimoto, A.: J. Physiol.383. 629-637 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Morimoto, A.: Pfl gers Arch.408. 414-416 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Morimoto, A.: J. Physiol.390. 137-144 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Watanabe, T.: Can. J. Physiol. Pharmacol.65. 1382-1388 (1987)

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      1987 Annual Research Report
  • [Publications] Ono, T.: J. Appl. Physiol.63. 175-180 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Morimoto, A.: J. Physiol.391. 209-218 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Watanabe, T.: J. Appl. Physiol.63. 918-922 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Morimotof, A.: J. Physiol.392. 637-649 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Morimoto, A.: Pfl gers Arch.410. 554-556 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Murakami, N.: "Pathophysiology of fever in patients of cerebral or subarachnoid hemorrhages. In: Man in stressful environmentstj- Thormor and Work Physiology" Shiraki, K. and Yousef, M. K. Charles C. Thomas, Springfield, Illinois, 11 PAGES (1987)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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