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Diagnosis and Treatment of Lung Cancer with Cell Engineering Technique

Research Project

Project/Area Number 62440053
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionChiba University

Principal Investigator

YAMAGUCHI Yutaka  Institute of Pulmonary Cancer Research, School of Medicine, Chiba University Surgery, (Professor), 医学部, 教授 (80009448)

Co-Investigator(Kenkyū-buntansha) BABA Masayuki  Institute of Pulmonary Cancer Research, School of Medicine, Chiba University Sur, 医学部, 助手 (00143305)
SHIBA Mitsutoshi  Institute of Pulmonary Cancer Research, School of Medicine, Chiba University Sur, 医学部, 助手 (20162620)
KIMURA Hideki  Institute of Pulmonary Cancer Research, School of Medicine, Chiba University Sur, 医学部, 講師 (10161572)
FUJISAWA Takehiko  Institute of Pulmonary Cancer Research, School of Medicine, Chiba University Sur, 医学部, 助教授 (80110328)
由佐 俊和  千葉大学, 医学部, 助手 (10182669)
斉藤 博明  千葉大学, 医学部, 助手 (40186953)
Project Period (FY) 1987 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥28,600,000 (Direct Cost: ¥28,600,000)
Fiscal Year 1990: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1989: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1988: ¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1987: ¥16,500,000 (Direct Cost: ¥16,500,000)
Keywordsmonoclonal antibody / Surgery of lung cancer / Immunotherapy of lung cancer / lymphokine-activated-killer cell / Biological nature / unclear DNA / 肺癌 / IL2 / 外科療法 / 細胞工学 / モノクローナル抗体
Research Abstract

The objective of this study is to improve the diagnosis and treatment of lung carcinoma by using a cell engineering technique.
Recombinant IL2 could generate lymphokine-activated killer (LAK) cells which were cytotoxic to various kind of malignant tumor cells. We applied for cases with lung carcinomas in clinical setting and found that survival rate in group treated with LAK was better than those in group treated with chem otherapy alone or control group in cases not only with relative curative but also noncurat ive resection. LAK therapy, furthermore, showed clinical benefit in 8 cases with postoperative recurrence or unresectable advanced diseases, when either LAK was stimulated with autologous cancer cells inactivated by MMC or infused topically via bronchial artery. Monoclonal antibody produced by hybridoma technique (3H12) was reactive both to small cell lung carcinoma and myeloid leucemia at myeloid crisis, indicating that this monoclonal antibody is considered to be useful for the diagnosis of not only small cell carcinoma but also subtype of myeloid leucemia. We developed nude mice in vivo experimental model by using cultured human bronchial epithel obtained from an infant dead by non-malignant or non-hereditary reasons and this model can be applied for in vitro carcinogenesis experiment. Nuclear DNA anlysis demonstrated that survival rate in cases with aneuploid pattern was significantly less than that in diploid pattern, suggesting aneuploid pattern is considered to include higher malignant potentiality.

Report

(5 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • Research Products

    (71 results)

All Other

All Publications (71 results)

  • [Publications] 山口 豊、藤沢 武彦、木村 秀樹: "原発性肺癌切除術後の集学的治療に関する研究" がん治療のあゆみ. 7. 137-144 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 馬場 雅行、山口 豊、藤沢 武彦、木村 秀樹: "肺癌術後局所再発およぴ転移性肺腫瘍に対する局所療法" 癌と化学療法. 15. 1342-1350 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 山口 豊、籾木 茂、木村 秀樹、小川 利隆、他: "肺小細胞癌の集学的治療に占める外科療法の意義" 胸部外科. 41. 184-189 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 藤沢 武彦、深沢 敏男、斉藤 幸雄、卜部 憲和 他: "肺癌切除例における自家ならびに他家腫瘍細胞に対する細胞障害活性の経時的変動" 癌の臨床. 34. 1922-1926 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 木村 秀樹、山口 豊、藤沢 武彦、馬場 雅行 他: "肺腫瘍に対する ILー2、LAK cell による養子免疫療法" BIOTHERAPY. 2. 1131-1137 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 山口 豊: "肺癌の集学的治療の現況" 外科治療. 59. 424-431 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 木村 秀樹、山口 豊、岩井 直路、柏谷 敦子、他: "癌性胸水に対するRecombinant ILー2の胸腔内投与" 日本癌治療学会誌. 23. 1580-1584 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 光永 伸一郎、木村 秀樹、山口 豊: "原発性肺癌における腫瘍細胞および腫瘍内浸潤リンパ球の数量的解析の試み" 日本癌治療学会誌. 23. 1467-1472 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 柴 光年、山口 豊、木村 秀樹、小川 利隆 他: "進行期肺非小細胞癌に対する術前化学療法の検討" 日本胸部外科学会雑誌. 36. 1089-1095 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 藤沢 武彦、深沢 敏男、斉藤 幸雄、卜部 憲和 他: "肺癌切除例における細胞障害活性に関する検討" Oncologia. 21. 99-105 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 木村 秀樹、山口 豊、小幡 貞男、由佐 俊和 他: "原発性肺癌に対する気管支動脈内stーLAKcell注入" 癌と化学療法. 15. 2401-2404 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M.Baba,T.Obara,R.D.Bonfil,Y.Yamaguchi,B.F.Trump,J.Resau and et al.: "Resistance to serumーinduced terminal differentiation in normal human trachobronchial epithelial cells after invivo exposure to 7,12ーdimetylbenz[α] anthracene" Gann. 79. 734-741 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S.Mitsunaga,H.Kimura,Y.Yamaguchi,A.Mikata: "Effect of recombinant human interleukin 2 on the growth of a BALB/c sarcoma induced by Molony murine sarcoma virus" Gann. 79. 965-972 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 木村 秀樹、山口 豊: "肺癌に対するILZ,LAK細胞による受動免疫療法" 日本外科学会雑誌. 90. 1459-1462 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 山口 豊、馬場 雅行、渋谷 潔、藤野 道夫 他: "進行肺癌に外科ー治療方針" 外科診療. 31. 1449-1456 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 木村 秀樹、山口 豊、小幡 貞男、籾木 茂、他: "肺非小細胞癌に対する術前化学療法の検討" 呼吸器外科. 3. 302-308 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 木村 秀樹、山口 豊、藤沢 武彦、柴 光年 他: "N_2症例の成績と手術適応" 日本胸部外科学会雑誌. 37. 884-885 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 馬場 雅行、山口 豊、山川 久美、 他: "ヒト気管(支)実験モデルの作製" 呼吸. 8. 713-718 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 木村 秀樹、山口 豊: "ILー2、LAK療法の宿主免疫能に題する影響" BIOTHERAPY. 4. 1762-1767 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 山口 豊: "肺臓外科における基礎的進歩とその展望" 日本外科学会雑誌. 91. 1133-1136 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 由佐 俊和、山口 豊、斉藤 幸雄、山川 久美 他: "肺癌治癒切除後の血行性転移にかかわる臨床病理学的因子に関する検討ー腺癌と扁平上皮癌の相違について" 肺癌. 30. 35-41 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T.Iizasa,Y.Yamaguchi,M.Tagawa,H.Saitoh,M.Fujisawa,K.Kato,et al.: "Establishment of human monoclonal antibody recognizing a new tumorーassociated antigen from a patient with small cell lung carcinoma" HYBRIDOMA.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] "Human monoclonal antibody detects a cell surface antigen expressed on hematopoietic malignant cells lymphoid lineage" Jpn J Cancer Res.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 川野 裕、木村 秀樹、山口 豊: "肺悪性腫瘍における腫瘍細胞核の形態変化を指標としたin vitro制癌剤感受性試験と術後adjuvant chemotherapyへの応用" 肺癌. 31. 69-75 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yutaka Yamaguchi, Takehiko Fujisawa, Hideki kimura: "Multi-modality treatment for resected, primary lung carcinoma in special reference to immunochemotherapy for the suppression of postoperative recurrence." Advances in Cancer Treatment. 7. 137-144 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Masayuki Baba, Yutaka yamaguchi, Takehiko Fujisawa, Hideki kimura: "The effects of localized therapy with postsurgical local recurrences of lung carcinoma and metastatic lung tumors-laser irradiation, 1L-2+LAK or ethanol injection." Jpn J Cancer Chemother. 15. 1342-1350 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yutaka Yamaguchi, Shigeru Momiki, Hideki Kimura, Toshitake Ogawa, Masayuki Baba: "The role of surgical treatment in the combination therapy for small cell lung cancer(SCLC)." Thorac Surg. 41. 184-189 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takehiko Fujisawa, Toshio Fukasawa, Yukio Saitoh, Norikazu Urabe, Yasusi Nomoto, Hisami Yamakawa, Masayuki Baba, Hideki Kimura, Yutaka Yamaguchi: "Postoperative sequential testing of cytotoxic activity against the autologous and allogeic tumor cells in primary lung resected cancer patients." Jpn J Cancer Clin. 34. 1922-1926 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Hideki Kimura, Yutaka Yamaguchi, Takehiko Fujisawa, Masayuki Baba, Mitsutoshi Shiba, Toshikazu Yusa, Hisami Yamakawa, Sadao Obata,: "Adoptive immunotherary of LAK cells against primary and metastatic lung tumors." Biotherapy. 2. 1131-1137 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yutaka Yamaguchi: "Present status of multi-modality treatment for lung cancers." Surg Treat. 59. 424-431 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Hideki Kimura, Yutaka Yamaguchi, Naomichi Iwai, Atsuko Kashiwaya, Hisami Yamakawa, Masayuki Baba, Takehiko Fujisawa: "Intrapleural instillation of recombinant 1L-2 in a patient with pleuritis carcinomatosa." J Jpn Soc Cancer Ther. 23. 1580-1584 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Shin-ichiro Mitsunaga, Hideki Kimura, Yutaka Yamaguchi: "Quantitative analysis of tumor cells and tumor infiltrating lymphocytes in primary lung cancer patients." J Jpn Soc Cancer Ther. 23. 1467-1472 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Mitsutoshi Shiba, Yutaka Yamaguchi, Hideki Kimura, Toshitake Ogawa, Hisami Yamakawa, Yutaka Kawano, Norikazu Urabe, Takehiko Fujisawa, Keiichi Nagao, Takayuki Kuriyama: "Clinical study on the role of postoperative chemotherapy for the advanced stage of non-small cell lung cancer." J Jpn Assoc Thor Surg. 36. 1089-1098 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takehiko Fujisawa, Toshio Fukusawa, Yukio Saitoh, Norikazu Urabe, Yasushi Nomoto, Hisami Yamakawa, Masayuki Baba, Hideki Kimura, Yutaka Yamaguchi: "Cytotoxic activity in primary resected lung cancer patients." Oncologia. 21. 99-105 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Hideki Kimura, Yutaka Yamaguchi, Sadao Obata, Toshikazu Yusa, Yasuo Sekine: "Bronchial arterial infusion of lymphokine-activated killer cells stimulated by autologous tumor cells." Jpn J Cancer Chemother. 15. 2401-2404 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Masayuki Baba, Takeshi Obara, R D Bonfil, Yutaka Yamaguchi, B F Trump, J Resau, AJP Klein-Szanto: "Resistance to serum-induced terminal differentiation in normal human tracheobronchial epithel cells after in vivo exposure to 7, 12-dimethylbenz [alpha]anthracene." Jpn J Cancer Res. 79. 734-741 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Shin-ichiro Mitsunaga, Hideki Kimura, Yutaka Yamaguchi, Atsuo Mikata: "Effect of recombinant interleukin 2 on the growth of a BALB/c sarcoma induced by Moloney murine sarcoma virus." Jpn J Cancer Res. 79. 965-972 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Hideki Kimura, Yutaka Yamaguchi: "Adoptive immunotherary with LAK cell and 1L2 against primary lung cancer." J Jpn Surg Soc. 90. 1459-1462 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yutaka Yamaguchi, Masayuki Baba, Kiyoshi Shibuya, Michio Fujino, Emiko Odaka, Makoto Suzuki: "Surgical treatment discipline for advanced lung cancer." Surg Treat. 31. 1449-1456 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Hideki Kimura, Yutaka Yamaguchi, Sadao Obata, Shigeru Momiki, Takehiko Fujisawa, Masayuki Baba, Mitsutoshi Shiba, Toshikazu Yusa: "Preoperative chemotherapy for advanced non-small cell lung cancer ; a preliminary study." J Jpn Assoc Surg. 3. 302-308 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Hideki Kimura, Yutaka Yamaguchi, Takehiko Fujisawa, Mitsutoshi Shiba, Toshikazu Yusa, Hisami Yamakawa, Sadao Obata, Norihisa Tamiya, Naomichi Iwai, Toshio Fukasawa, Yasushi Nomoto, Kiyoshi Shibuya, Emiko Nishioka: "Results of N2 cases and surgical indication." J Jpn Assoc Thor Surg. 37. 884-885 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Masayuki Baba, Yutaka Yamaguchi, Hisami Yamakawa, AJP Klein-Szanto: "Au in vivo model for human tracheobronchial experimental carcinogenesis." Respiration. 8. 713-718 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Hideki Kimura, Yutaka Yamaguchi: "Effect of adoptive immunotherapy by 1L-2 and LAK cell on the host immune response of primary lung cancer patients." Biotherapy. 4. 1762-1767 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yutaka Yamaguchi: "The advancement and the future application of basic research in lung surgery." J Jpn Surg Soc. 91. 1133-1136 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Toshikazu Yusa, Yutaka Yamaguchi, Yukio Saitoh, Hisami Yamakawa, Sadao Obata, Mitsutoshi Shiba, Hikeki Kimura, Takehiko Fujisawa, Hidemi Ohwada, Yutaka Hayashi: "Comparison of adenocarcinoma and squamous cell carcinoma of the lung in terms of clinicopathological factors related to hematogenous metastasis after curative resection." Lung Cancer. 30. 35-41 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Toshihiko Iizasa, Yutaka Yamaguchi, Masatoshi Tagawa, Hiroaki Saitoh, Takehiko Fujisawa, Kanefusa Kato, Masaru Taniguchi: "Establishment of human monoclonal antibody recognizing a new tumor associated antigen from a patient with small cell lung carcinoma." Hybridoma. 9. 211-219 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Toshihiko Iizasa, Yutaka Yamaguchi, Masatoshi Tagawa, Takehiko Fujisawa, Hiroaki Saitoh, Haruki Kondo, Yoshinobu Matsuo, Jun Minowada, Masaru Taniguchi: "Human monoclonal antibody detects a cell surface antigen expressed on hematopoietic malignant cells of lymphoid lineage." Jpn J Cancer Res. 82. 213-218 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yutaka Kawano, Hideki Kimura, Yutaka Yamaguchi: "In vitro sensitivity test based on cytomorphological changes of nuclei and applications for post-operative adjuvant chemotherapy of lung cancer." Lung Cancer. 31. 69-75 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 木村 秀樹.山口 豊: "ILー2,LAK療法の宿主免疫能に対する影響" BIOTHERAPY. 4. 1762-1767 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 山口 豊: "肺臓外科における基礎的進歩とその展望" 日本外科学会雑誌. 91. 1133-1136 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 由佐 俊和,山口 豊,斉藤 幸雄,山川 久美他: "肺癌治癒切除後の血行性転移にかかわる臨床病理学的因子に関する検討ー腺癌と扁平上皮癌の相違について" 肺癌. 30. 35-41 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Iizasa,Y.Yamaguchi,M.Tagawa,H.Saitoh,T.Fujisawa,K.Kato,et al.: "Establishment of human monoclonal antibody recognizing a new tumorーassociated antigen from a patient with small cell lung carcinoma" HYBRIDOMA. 9. 211-219 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Iizasa,Y.Yamaguchi,M.Tagawa,T.Fujisawa,H.Saito,H.Kondo,etal.: "Human monoclonal antibody detects a cell surface antigen expressed on hematopoietic malignant cells of lymphoid lineage" Jpn J Cancer Res. 82. 213-218 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 川野 裕,木村 秀樹,山口 豊: "肺悪性腫瘍における腫瘍細胞核の形態変化を指標としたin vitro制癌剤感受性試験と術後adjuvant chemotherapyへの応用" 肺癌. 31. 69-75 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Hideki Kimura and Yutaka Yamaguchi: "Cytotoxic Activity of Various LAK Cells against Autologous Lung Cancer,Kー562 Daudi Cells" Jpn.J.Clin.Oncol.19. 222-228 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 木村秀樹,山口豊,藤沢武彦,柴光年,他: "N_2症例の成績と手術適応" 日本胸部外科学会雑誌. 37. 884-885 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 木村秀樹,山口豊,小幡貞男,他: "肺非小細胞癌に対する術前化学療法の検討" 日本呼吸器外科学会雑誌. 3. 302-308 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 木村秀樹,山口豊: "肺癌に対するIL2,LAK細胞による受動免疫療法" 日本外科学会雑誌. 90. 1459-1462 (1989)

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      1989 Annual Research Report
  • [Publications] 由佐俊利,山口豊,斉藤幸雄,他: "肺癌治癒切除後の血行性転移にかかわる臨床病理学的因子に関する検討ー腺癌と扁平上皮癌の相違についてー" 肺癌. 30. 35-41 (1990)

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      1989 Annual Research Report
  • [Publications] 馬場雅行,山口豊,藤沢武彦,木村秀樹: 癌と化学療法. 15. 1342-1350 (1988)

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      1988 Annual Research Report
  • [Publications] Hideki,Kimura;Yutaka,Yamaguchi: GANN. (1989)

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      1988 Annual Research Report
  • [Publications] Shin-ichiro,Mitshaga;Hideki,Kimura;Yutaka,Yamaguchi;Atsuo,Mikata: GANN. (1989)

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      1988 Annual Research Report
  • [Publications] 藤沢武彦,深沢敏男,斉藤幸雄,ト部憲和,野本靖史,山川久美,馬場雅行,木村秀樹,山口豊: Dncologia. 21. 99-105 (1988)

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      1988 Annual Research Report
  • [Publications] 藤沢武彦,深沢敏男,斉藤幸雄,ト部憲和,野本靖史,山川久美,馬場雅行,木村秀樹,山口豊: 癌の臨床. 34. 1922-1926 (1988)

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      1988 Annual Research Report
  • [Publications] 山口豊,藤沢武彦,木村秀樹: "がン集学的治療研究報告書" がん集学的治療研究財団, 137-144 (1988)

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      1988 Annual Research Report
  • [Publications] 馬場雅行,山口豊,藤沢武彦,木村秀樹: 癌と化学療法.

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      1987 Annual Research Report
  • [Publications] Hideki Kimura; Yutaka Yamaguchi: GANN. (1988)

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      1987 Annual Research Report
  • [Publications] Shin-ichiro Mitsunaga; Hideki Kimura; Yutaka Yamaguchi; Atsuo Mikata: GANN.

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      1987 Annual Research Report
  • [Publications] 藤沢武彦,深沢敏男,斉藤幸雄,卜部憲和,野本清史,山川久美,馬場雅行,木村秀樹,山口豊: Dncologia.

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      1987 Annual Research Report
  • [Publications] 藤沢武彦,深沢敏男,斉藤幸雄,卜部憲和,野本靖史,山川久美,馬場雅行,木村秀樹,山口豊: 癌の臨床.

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      1987 Annual Research Report
  • [Publications] 山口豊,藤沢武彦,木村秀樹: "がん集学的治療研究報告書" がん集学的治療研究財団, (1988)

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      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2017-10-19  

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