| Project/Area Number |
62440064
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
麻酔学
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
KOBAYASHI Kenichi Jikei University School of Medicine, the medical department, Professor, 医学部, 教授 (50056470)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Motoo Jikei University School of Medicine the medical department, Assistant, 医学部, 助手 (20178776)
YASUDA Nobuhiko Jikei University School of Medicine the medical department, Assistant, 医学部, 助手 (80174514)
KAGESHIMA Kazuyuki Jikei University School of Medicine, the medical department, Assistant, 医学部, 助手 (80185727)
MISHIMA Kimi Jikei University School of Medicine the medical department, Assistant, 医学部, 助手 (70181873)
TANIFUJI Yasumasa Jikei University School of Medicine the medical department, Associate professor, 医学部, 助教授 (00056847)
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| Project Period (FY) |
1987 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 1989: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1988: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1987: ¥4,500,000 (Direct Cost: ¥4,500,000)
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| Keywords | Hepatic circulation / Hepatic metabolism / Induced hypotension / Urinastation / Renal function / Dopamine / Hemorrhage hypotension sive / 腎機能 / ド-パミン / ドブタミン / 肝血流量 / ドパミン / 脱血性低血圧 / Ca拮抗薬 / ニカルジピン / 人為低血圧麻酔 / 肝酸素消費量 / 腎血流量 / ウリナスタチン |
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| Research Abstract |
1. A comparison of effect among trimetaphan(TM), adenosine triphosphate(ATP), and nitroglycerine (NTG) induced hypotension(MAP 60mmHg) on hepatic circulation and metabolism in dogs under 1 MAC enflurane. As results, hepatic arterial blood flow did not significantly change by three drugs, but portal venous blood flow significantly in creased by NTG < ATP, significantly decreased by TM. Whereas hepatic oxygen consumption did not change by the three drugs, but hepatic oxygen supply significantly increase NTG < ATP, significantly decreased by TM. It suggest that hepatic circulation and metabolism should be well maintained during ATP induced hypotension compared with NTG and TM hypotension.
2. Effect of urinastation on renal blood flow and urine volume with TM hypotension under 1MAC halothane in dogs. Hypotension was induced and maintained 50-60% of control blood pressure for 1 hour. Administration of urinastation was started at the beginning of anesthesia and dripped continuously at the rate of 50,000 U/kg/hour till the end of experiments. As results, renal blood flow decreased significantly in control group but not in urinastation group. Urine volume decreased significantly during hypotension in both group and it could not recovered in control group. However urine volume of urinastation group at recovery period was twice higher than control group. It seems that urinastation is beneficial for renal function during deliberate hypotension.
3. Effects of dopamine and dobutamine on hepatic circulation and metabolism in hemorrhagic hypotension(MAP 50mmHg) under 1MAC enflurane in pigs.
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