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Physicochemical Basis of Information Processing in Ameboid Cells in Relation to Perception of Lower Organisms

Research Project

Project/Area Number 62460214
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Physical pharmacy
Research InstitutionHokkaido University

Principal Investigator

KAMO Naoki (1988-1989)  Faculty of Pharmaceutical Sciences, Hokkaido University, 薬学部, 助教授 (10001976)

小畠 陽之助 (1987)  北海道大学, 薬学部, 教授 (80028092)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Kenji  Faculty of Pharmaceutical Sciences, Hokkaido University, 薬学部, 教務職員 (80183953)
TAKAHASHI Tetsuo  Faculty of Pharmaceutical Sciences, Hokkaido University, 薬学部, 助手 (90133769)
UEDA Tetsuo  Faculty of Pharmaceutical Sciences, Hokkaido University, 薬学部, 助手 (20113524)
加茂 直樹  北海道大学, 薬学部, 助教授 (10001976)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1988: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1987: ¥5,200,000 (Direct Cost: ¥5,200,000)
KeywordsHalobacterium halobium / Physarum polycephalum / Phase waves / Non-linear oscillation / Entrainment of waves / Activated oxygen / Phototaxis / 細胞の知覚 / 情報伝達の物理 / 情報判断
Research Abstract

1) Halobacterium halobium shows positive and negative phototaxis. Receptors of the phototaxis were identified. The photochemistry of receptor pigments was investigated with flash-photolysis and low-temperature spectrophotometry.
2) Uni-cellular organisms are able to perceive changes of their environment behave accordingly just as higher animals do. A mechanism of information processing in true slime mold, Physarum polycephalum is investigated. This organism extends like a sheet at the frontal part, and intricate veins develop toward the rear, in which the protoplasmic sol moves to and fro very regularly.
The period of this regular movement is about 2 minutes. Because this regular movement accompanies changes of the thickness of the vein, oscillatory signals of transmitted light can be observed. We have analyzed the dynamic behavior of the intrinsic rhythm with the help of computer image processing. When a part of the plasmodium is stimulated with temperature, chemicals or light, waves of thickness oscillation propagate throughout the organism, the phase around the stimulated region being advanced or retarded for attractants or repellents, respectively. This suggests that the intracellular information processing within the plasmodium is related to dynamic cooperative behavior in a population of coupled non-linear oscillators.
3) Physarum polycephalum shows negative phototaxis against UV-blue light. Action spectrum was determined, which accords well with action spectrum for generation of super oxide anion. In the absence of oxygen, no negative taxis is observed. These facts imply that super oxide anion is a mediator for the negative taxis.

Report

(3 results)
  • 1989 Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • Research Products

    (45 results)

All Other

All Publications (45 results)

  • [Publications] Y.Mori: "Spatio-Temporal organization of intracellular ATP content and oscillation patterns in response to blue light by Physarum polycephalum" Protoplasma. 135. 31-37 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M.Demura: "Binding of lipophilic cations to the liposomal membrane:thermodynamic analysis" Biochimica et Biophysica Acta. 903. 303-308 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M.Demura: "Mitochondrial membrane potential estimated with the correction of probe binding" Biochimica et Biophysica Acta. 894. 355-364 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T.Hosokawa: "Organization of community behavior during initiation of morphogentic aggregation in a population of Dicyostelium discoidem amoebae" Cell Structure and Function. 12. 497-502 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] N.Kamo: "Formation of blue membrane of bacteriorhodpsin.by addition of tetrakis(4-fluorophenyl)boron,an hydrophobic anion" Biochimica et Biophysica Acta. 904. 179-186 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T.Ueda: "Changes in cAMP and cGMP concentration,birefringent fibrils and contractile activity accompanying UV and blue light photoavoidance in plasmodia of an albino strain of Physarum polycephalum" Photochemistry and photobiology. 47. 271-275 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] N.Kamo: "On the glutamate transport through cell envelope vesicles of Halobacterium halobium" Biochem.Biophys.Res.Commun.157. 1090-1096 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Shichida: "Low-temperature spectrophotometry of phoborhodopsin" FEBS lett.236. 333-336 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T.Ueda: "Action spectra for superoxide generation and UV and visible light photoavoidance in plasmodia of Physarum polycephalum" Photochemistry and photobiology. 48. 705-709 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T.Ueda: "Patterns in intracellular ATP distribution and rhythmic contraction in relation to amoeboid locomotion in the plasmodium of Physarum polycephalum" Protoplasma. Suppl1. 51-56 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K.Matsumoto: "Reversal of thermotaxis with oscillatory stimulation in the plasmodium of Physarum polycephalum" J.Their.Biol.131. 175-182 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] S.Kurosawa: "Plasma-Polymerized membrane electrode selective to lipophilic cations" J.Membrane Science(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Mori: "Spatio-Temporal organization of intracellular ATP content and oscillation patterns in response to blue light by Physarum polycephalum" Protoplasma. 135. 31-37 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M.Demura: "Binding of lipophilic cations to the liposomal membrane: thermodynamic analysis" Biochimica et Biophysica Acta. 903. 303-308 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M.Demura: "Mitochondrial membrane potential estimated with the correction of probe binding" Biochimica et Biophysica Acta. 894. 355-364 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T.Hosokawa: "Organization of community behavior during initiation of morphogentic aggregation in a population of Dicyostelium discoidem amoebae" Cell Structure and Function. 12. 497-502 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] N.Kamo: "Formation of blue membrane of bacteriorhodpsin.by addition of tetrakis(4-fluorophenyl)boron, an hydrophobic anion" Biochimica et Biophysica Acta. 904. 179-186 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T.Ueda: "Changes in cAMP and cGMP concentration, birefringent fibrils and contractile activity accompanying UV and blue light photoavoidance in plasmodia of an albino strain of Physarum polycephalum" Photochemistry and photobiology. 47. 271-275 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] N.Kamo: "On the glutamate transport through cell envelope vesicles of Halobacterium halobium" Biochem.Biophys.Res.Commun.157. 1090-1096 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Shichida: "Low-temperature spectrophotometry of phoborhodopsin" FEBS lett.236. 333-336 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T.Ueda: "Action spectra for superoxide generation and UV and visible light photoavoidance in plasmodia of Physarum polycephalum" Photochemistry and photobiology. 48. 705-709 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T.Ueda: "Patterns in intracellular ATP distribution and rhythmic contraction in relation to amoeboid locomotion in the plasmodium of Physarum polycephalum" Protoplasma. Suppl 1. 51-56 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K.Matsumoto: "Reversal of thermotaxis with oscillatory stimulation in the plasmodium of Physarum polycephalum" J. Theor.Biol.131. 175-182 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] S.Kurosawa: "Plasma-Polymerized membrane electrode selective to lipophilic cations" J.Membrane Science. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] N.Hazemoto: "Plasma-Polymerized membrane electrode for the determination of dextromethorophan and dimemorfan" Chem.Pharm.Bull. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] E. Tawara: "Factors determining the oscillation frequency of piezoelectric quartz in aqueous solutions" Anal.Chim.Acta. to be submitted.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] S.Kurosawa: "Adsorption of various gases to plasma-polymerized phthalocyanine" Anal.Chem.to be submitted.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] S.Kurosawa: "Sensor for mutagen with use of piezo-electric quartz" Mutation Res.to be submitted.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T.Ueda: Photochemistry and photobiology. 47. 271-275 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] N.Kamo: Biochem.Biophys.Res Commun.157. 1090-1096 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Y.Shichida: FEBS left.236. 333-336 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Ueda: Photochemistry and photobiology. 48. 705-709 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Ueda: Protoplasma. Suppl1. 51-56 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Matsumoto: J.Theor,Biol.131. 175-182 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] S.Kurosawa: J.Membrane Science.

    • Related Report
      1988 Annual Research Report
  • [Publications] N.Hazemoto: Chem.Pharm.Bull.

    • Related Report
      1988 Annual Research Report
  • [Publications] E.Tawara: Anal.Chim.Acta.

    • Related Report
      1988 Annual Research Report
  • [Publications] S.Kurosawa: Anal.Chem.

    • Related Report
      1988 Annual Research Report
  • [Publications] S.Kurosawa: Mutation Res.

    • Related Report
      1988 Annual Research Report
  • [Publications] M.Demura: Biochimica et Biophysica Acta. 903. 303-308 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] M.Demura: Biochimica et Biophysica Acta. 894. 355-364 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Y.Mori: Protoplasma. 135. 31-37 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] T.Hosokawa: Cell Structure and Function. 12. 497-502 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] N.Kamo: Biochimica et Biophysica Acta. 904. 179-186 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] T.Ueda: Photochemistry and Photobiology. 47. 271-275 (1988)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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