• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Search for Bioactive Marine Natural Products

Research Project

Project/Area Number 62470137
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Chemical pharmacy
Research InstitutionOsaka University

Principal Investigator

KITAGAWA Isao  Osaka University, Professor, 薬学部, 教授 (20028830)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Masayuki  Osaka University, Associate Professor, 薬学部, 助教授 (90116129)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥7,500,000 (Direct Cost: ¥7,500,000)
Fiscal Year 1988: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1987: ¥6,000,000 (Direct Cost: ¥6,000,000)
KeywordsMarine organism / Marine natural products / Marine sponge / Oligoglycoside / Oligopeptide lactone / Alkaloid / 海洋天然物質 / 化学構造 / マクロリド / 異常ヌクレオシド / アミノ酸分析 / 受精卵卵割阻害活性 / 14ーノルラノスタン / Nーアセチルガラクトサミン
Research Abstract

Marine organisms comprise over half a million species. Due to their unusual living environment as compared with terrestrial organisms, marine organisms metabolite and produce a variety of substances which often have various unprecedented chemical structures and biological activities. During the course of continuing studies in search of new biologically active substances from marine organisms, we have studied several marine sponges collected in the coral reef of Okinawa Prefecture and Palau Islands.
1. Bioactive five lactones named theonellapeptolides Ia, Ib, Ic, Id, and Ie were isolated from the Okinawan marine sponge Theonella swinhoei and elucidated their absolute stereostructures by a new HPLC method for N-methly amino acids which was developed to analyze the amino acid composition of these peptide lactones. These peptide lactones are cytotoxic for L1210 cell and exhibit ionophoric activities to Na^+, K^+, and Ca^<++>
2. Nine new norlanostane-triterpenoid oligoglycosides, sarasinosides A_1, A_2, A_3, B_1, B_2, B_3, C_1 C_2, and C_3 were isolated from the Palauan marine sponge Asteropus sarasinosum and their structures were determined. These oligoglycosides exhibit ichthyotoxic activity and inhibit cell division of fertilized eggs ofthe starfish.
3. Nine novel macrocyclic alkaloids, araguspongines A-H, and J were isolated from an Okinawan marine sponge Xestospongia sp. and their absolute stereostructures were determined. These alkaloids having two l-oxaquinolizidine moieties exhibit potent vasodilative activity.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] I.,Kitagawa: Chem.Pharm.Bull.,. 35. 124-135 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I.,Kitagawa: Chem.Pharm.Bull.,. 35. 928-931 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I.,Kitagawa: Chem.Pharm.Bull.,. 35. 2129-2132 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I.,Kitagawa: Chem.Pharm.Bull.,. 35. 5036-5039 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I.,Kitagawa: Yakugaku Zasshi. 108. 398-416 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I.,Kitagawa: Chem.Pharm.Bull.,. 37. 61-67 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I.,Kitagawa: Chem.Pharm.Bull.,. 37. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I.,Kitagawa: Chem.Pharm.Bull.,. 37. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I.,Kitagawa: Chem.Pharm.Bull.,. 37. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I. Kitagawa: "Marine Natural Products. XVII. Nephtheoxydiol, a New Cytotoxic Hydroperoxy-Germacrane Sesquiterpene, and Related Sesquiterpenoids from an Okinawan Soft Coral of Nephthea sp." Chem. Pharm. Bull.,. 35. 124-135 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I. Kitagawa: "Four New Bisabolene-type Aminosesquiterpenes from an Okinawan Marine Sponge, Theonella sp. (Theonellidae)." Chem. Pharm. Bull.,. 35. 928-931 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I. Kitagawa: "Structure of Theonellapeptolide Ie, a New Tridecapeptide Lactone from an Okinawan Marine Sponge, Theonella sp. (Theonellidae)" Chem. Pharm. Bull.,. 35. 2129-2132 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I. Kitagawa: "Structures of Sarasinosides A_1, B_1, and C_1: New Norlanostane- Triterpenoides from the Palauan Marine Sponge Asteropus sarasinosum" Chem. Pharm. Bull.,. 35. 5036-5039 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I. Kitagawa: "Bioactive Marine Natural products" Yakugaku Zasshi. 108. 398-416 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I. Kitagawa: "Marine Natural Products. XVIII. Four Lanostane-type Triterpene Oligoglycosides, Bivittosides A, B, C, and D, from the Okinawan Sea Cucumber Bohadschia bivittata Mitsukuri" Chem. Pharm. Bull.,. 37. 61-67 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I. Kitagawa: "Marine Natural Products. XX. Pervicosides A, B, and C, Lanostane-type Triterpene-Oligoglycoside Sulfates from the Sea Cucumber Holothuria pervicax" Chem. Pharm. Bull.,. 37. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I. Kitagawa: "Heterosigma-glycolipids I and II, Two New Galactolipids Containing Octadecatetraenoyl and Eicosapentaenoyl Residues, from a Rahidophyte Dinoflagellate Heterosigma sp." Chem. Pharm. Bull.,. 37. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] I. Kitagawa: "Marine Natural Products. XX. Bioactive Scalarane-type Bishomo-sesterterpenes from the Okinawan Marine Sponge Phyllospongia foliascens" Chem. Pharm. Bull.,. 37. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 北川勲: 薬学雑誌. 108. 398-416 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] I.Kitagawa: Chem.Pharm.Bull.37. 61-67 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] I.Kitagawa: Chem.Pharm.Bull.37. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] I.Kitagawa: Chem.Pharm,Bull.37. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] I.Kitagawa: Chem.Pharm.Bull.37. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] M.Kobayashi: Chem.Pharm.Bull.34. 2306-2309 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] I.Kitagawa: Chem.Pharm.Bull.34. 2664-2667 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] I.Kitagawa: Chem.Pharm.Bull.34. 4590-4596 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] I.Kitagawa: Chem.Pharm.Bull.34. 4641-4652 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] I.Kitagawa: Chem.Pharm.Bull.35. 124-135 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] I.Kitagawa: Chem.Pharm.Bull.35. 928-931 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 北川勲 編者: 海洋天然物化学. 化学増刊111号. 205 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] I.Kitagawa: Chem.Pharm.Bull.35. 2129-2132 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] I.Kitagawa: Chem.Pharm.Bull.34. 5036-5039 (1987)

    • Related Report
      1987 Annual Research Report

URL: 

Published: 1987-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi