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Neuroendocrine Regulation on Age-related Changes of Reproductive Function

Research Project

Project/Area Number 62480023
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 動物形態・分類学
Research InstitutionUniversity of Tokyo (1988)
Hiroshima University (1987)

Principal Investigator

KAWASHIMA Seiichiro  Faculty of Science, Hiroshima University (until 1988 Sept) Faculty of science, University of Tokyo (from 1988 Oct), 理学部, 教授 (20011554)

Co-Investigator(Kenkyū-buntansha) MORI Takao  Faculty of Science, University of Tokyo. (from 1988 Oct), 理学部, 講師 (80011659)
TSUTSUI Kazuyoshi  Faculty of Science, Hiroshima University (until 1988 Sept), 理学部, 助手 (20163842)
TAKAHASHI Sumio  Faculty of Science, Hiroshima University, 理学部, 助手 (90144807)
MACHIDA Takeo  Faculty of Science, Hiroshima University (until 1988 Sept), 理学部, 助教授 (70073020)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1988: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1987: ¥3,500,000 (Direct Cost: ¥3,500,000)
KeywordsReproductive function / aging / central nervous system / LHRH / FSH receptor / prolactin / growth hormone / ニューロンの可塑性 / 神経内分泌 / ゴ ナドメロピン受容体 / 腎臓病変 / 子宮病変 / 前葉ホルモン / ラット / マウス / 培養
Research Abstract

The purpose of the present study is to analyze the mechanism of age-relate changes of reproductive function, with special reference to neuroendocrine function. The important findings are summarized as follows.
1. The results of immonocytochemistry and radioimmonoassay revealed that LHRH neurons start functioning earlier in male rats than females. For the maintenance of cyclic release of LHRH and LH in adult female rats, the suprachiasmatic nucleus could normally play a role, if either the anterior or posterior afferents was left intact.
2. As concerns the pulsatile release of growth hormone (GH), old rats showed a decrease in pulse peak and pituitary content of GH. Simultaneously, the increase in the number of GH binding sites in hepatic membrane fraction and the decrease in plasma level of somatomedin-C were found.
3. Age-related changes in the hypothalamic-neurohypophyseal system was also studied. It was found that vasopressin neuronal plasticity was decreased as age advances. This finding affords an approach to age-related changes in other neuroendocrine system.
4. Follicle-stimulating hormone (FSH) receptor in the testes was low in affinity at first but before parturition the affinity increased to the adult level. In the mouse, the concentration of testicular FSH receptors increased until puberty similar to that in the rat. However, in the mouse fsh receptors decreased after puberty due to downregulation of FSH receptors. The electron microscopic autoradiography and kinetic study revealed that internalization of FSH-FSH receptor complex is important for the downregulation.
Representative reports for the present project are listed in the next page.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] K.Kawamoto: Brain Research. 422. 106-117 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] S.Kawashima: Proceedings of First Congress of Asia and Oceania Society for Comparative Endocrinology. 80-81 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] A.Shimizu: Endocrinologia Japonica. 34. 431-442 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] S.Takahashi: Neuroendocrinology. 46. 137-142 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K.Tsutsui: Endocrinologia Japonica. 34. 717-725 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Win Win Yee: Zoological Science. 4. 867-873 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K.Nomura: Neuroendocrinology. 47. 444-452 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] S.Takahashi: Anatomy and Embryology. 178. 475-480 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K.Tsutsui: Endocrinology. 122. 1094-1102 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T.Yamashita: Development,Growth and Defferentiation. 30. 563-571 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T.Mori: Zoological Science. 6. 103-112 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K.Tsutsui: General and Comparative Endocrinology. 73. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K. Nomura; S. Takahashi; S. Kawashima: "Maintenance of estrous cycle in female rats with anterior or posterior deafferentation of the suprachiasmatic nucleus." Neuroendocrinology.47. 444-452 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] S. Takahashi; R. Ono; K. Nomura; S. Kawashima: "Luteinizing hormone-releasing hormone (LHRH) neurons in the male and female rats at peripubertal period." Anatomy and Embryology. 480. 475-480 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K. Tsutsui; S. Kawashima; A. Masuda; T. Oishi: "Effects of photoperiod and temperature on the binding of follicle-stimulating hormone (FSH) to testicular preparations and plasma FSH concentration in the Djungarian hamster, Phodopussungorus." Endocrinology. 122. 1094-1102 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T. Yamashima; K. Kawamoto; S. Kawashima: "Arginine vasopressin contents of the hypothalamus and pituitary during fetal and postnatal development in the mouse." Development, Growth and Differentiation. 30. 563-571 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T. Mori; H. Nagasawa: "Causal analysis of the development of uterine adenomvosis in mice." Zoological Science. 6. 103-112 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] S. Kawashima; K. Kawamoto: Age-related changes in plasti city of vasopressin- and oxytocin- immunoreactive neurons in rats and mice. (Proceedings of the Internat. Svmp.on New Trends in Aging Research). Fidia SPA, (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K.Nomura: Neuroendocrinology. 47. 444-452 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] S.Takahashi: Anatomy and Embryology. 178. 475-480 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Tsutsui: Endocrinology. 122. 1094-1102 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Yamashita: Development,Growth and Defferentiation. 30. 563-571 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Mori: Zoological Science. 6. 103-112 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Tsutsui: General and Comparative Endocrinology. 73. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kawamoto,K.;S.Kawashima: Brain Research. 422. 106-117 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Win Win Yee;S.Kawashima: Journal of Science of Hiroshima University Series B,Division 1. 33. 1-9 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Shimizu,A;K.Tsutsui;S.Kawashima: Endocrinologia Japonica. 34. 431-442 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Takahashi,S.;S.Kawashima: Zoological Science. 4. 855-860 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Win Win Yee;S.Kawashima: Zoological Science. 4. 867-873 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Tsutsui K.;S.Kawashima: Endocrinologia Japonica. 34. 717-725 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Nomura,K.;S.Takahashi;S.Kawashima: Neuroendocrinology. (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Yamashita,T;K.Kawanoto;S.Kawashima: Zoological Science. 5. (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Tsutsui,K;S.Kawashima;A.Masuda;T.Oishi: Endocrinology. 122. (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Takase,M;K.Tsutsui;S.Kawashima: Endocrinologia Japonica. 35. (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Kobayashi,Y;S.Kawashima: Zoological Science. 5. (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Kobayashi,Y;S.Kawashima: Journal of Science of Hiroshima University,Series B,Division 1.33. (1988)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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