| Budget Amount *help |
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥5,400,000 (Direct Cost: ¥5,400,000)
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| Research Abstract |
1) The morphological plasticity of thyroid blood capillaries in long-term low-iodine-diet (LID)-treated rats was studied. By SEM of the corrosion cast, it was clear that the blood capillaries in the basket-like network surrounding each follicle become heterogeneously dilated and show many buddings, branches, and an anastomoses. By TEM, the capillary endothelial cells from the long-term LID-treated rats became larger in volume of the cytoplasm with well-developed rough endoplasmic reticulum, Golgi apparatus and numerous vesicles. The sproutings and the fusion of the capillaries were often seen. The ^3H-thymidine autoradiography demonstrated that DNA-synthesizing endothelial cells, pericaplillary cells, and follicle epithelial cells were markedly increased in number after 2-3 weeks of LID feeding. The thyroid capillaries are flexible and changed in morphology by functional states of the gland.
2) The three-dimensional architectures and the regional differences of the vascular system in the mucosa of teh hamster stomach were revealed by scanning electron microsoopy of corrosion casts. In the forestomach, the vascular network spreads two-dimensionally in a thin lamina propria. In the corpus and the antrum, the capillaries in the thick lamina propria are well developed, extending three-dimensionally along the gastric pits and glands. In the corpus, the submucosal arteries enter the lamina propria to become ascending capillaries, which project toward the top of the lamina propria and anastomose to create a capillary network beneath the mucosal epithelium. A subepithelial capillary is mcuh wider in diameter than an ascending capillary and is, therefore, a sinusoid capillary. Subepithelial capillaries join descending venules, which are less numerous than the ascending capillaries.
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