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A pharmacological study on the mechanism of capsaicin-induced corneal lesions.

Research Project

Project/Area Number 62480122
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionKagoshima University

Principal Investigator

FUKUDA Takeo  Faculty of Medicine, Kagoshima University. Professor., 医学部, 教授 (70038694)

Co-Investigator(Kenkyū-buntansha) SHIMIZU Takao  Faculty of Medicine, Kagoshima University. Instructor., 医学部, 講師 (10041336)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1988: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1987: ¥5,100,000 (Direct Cost: ¥5,100,000)
KeywordsCorneal lesion / Opacity / Capsaicin / Substance P / 6-OHDA / DSP4 / 交感神経 / 化学的交感神経切除 / 6-OHDA
Research Abstract

Capsaicin is known to cause damage to primary sensory afferent neurons, the neurotransmitter of which is believed to be substance P (SP). Following a single subcutaneous injection of capsaicin to neonatal mice, a high incidence of corneal lesions with opacity developed after a long latency. The intensity of the lesions progressed for about 1 month in animal which had received a high dose (50 or 100 mg/kg) of capsaicin. Although the intensity gradually decreased thereafter, 50% of animals still exhibited a visible opacity 6 months after treatment. Similar corneal lesions were also produced in neonatal rats which had been injected with capsaicin. It is suggested that the corneal lesions induced by capsaicin may be due to destruction of the trigeminal nerve. Pretreatment with a subcutaneous injection of 6-hydroxydopamine (6-OHDA) on the lst and 2nd postnatal day or on the 14th and 15th postnatal day led to a marked suppression of the capsaicin-induced corneal lelsions. The content of SP in the ocular anterior segments was decreased, dose-dependently, with capsaicin administration. 6-OHDA decreased the rate of capsaicin-induced reduction of SP. However, this effect of 6-OHDA was too slight to explain the suppression of the corneal lesions. these results suggest that the corneal changes induced by capsaicin are largely inhibited by a decreased activity in the sympathetic system.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] Takao Shimizu: J.Pharmacol.Exp.Ther.243. 690-695 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takao,Shimizu: "Capsaicin-induced corneal lesions in mice and the effects of chemical sympathectomy." J. Pharmacol. Exp. Ther.243. 690-695 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shimizu,Takao: J.Pharmacol.Exp.Ther.243. 690-695 (1987)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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