• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Immunopathological approach to pathogenesis of human idiapathic spermatogenic disorder

Research Project

Project/Area Number 62480137
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

HATAKEYAMA Shigeru  Tokyo Medical and Dental University, Medical Faculty Proffessor, 医学部, 教授 (30045926)

Co-Investigator(Kenkyū-buntansha) TERADA Takahiko  Tokyo Medical and Dental University, Medical Faculty Ass. Proffessor, 医学部, 助手 (90197799)
EISHI Yoshinobu  Tokyo Medical and Dental University, Medical Faculty Ass. Proffessor, 医学部, 助手 (70151959)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥5,500,000 (Direct Cost: ¥5,500,000)
KeywordsSpermatogenic disorder / Autoimmunity / Anti-Sertoli cell autoantibody / 精細管基成膜 / 精細管基底膜
Research Abstract

Human autoantibody to Sertoli cells was detected in normal human sera. This IgM-type autoantibody was undetectable during neonatal period and was found in 11.5% of 365 serum samples taken from adult healthy persons of both sexes. This human autoantibody to Sertoli cells exhibited quite the same target-organ specificity and:multi-organ reactivity as those of the murine monoclonal autoantibody(IgM class) to Sertoli cells (TM-1: WHO registered code T43) which has already been demonstrated capable of inducing experimental spermatogenic disturbance in mice. These human and murine autoantibodies could recognize testicular self-antigens of molecular weight 67,000 and 23,000 in Sertoli cells.
Monoclonal antibody to basement membrane of the seminiferous tubules (TM-2: WHO registered code T44) allowed the autoantibody to reach the Sertoli cells across the blood-testis barrierr. Autoantibody with the same target-tissue specificity as TM-2 was also demonstrated in human sera, both recognizing type-IV collagen molecules as target self-antigens of the testis.
Thus, human spermatogenic disturbance could be easily induced even in healthy individuals, once a functional impairment of Sertoli cells and blood-testis barrierr composed mainly of basement membrane of seminiferous tubules were induced by either these naturally-occuring autoantibodies or other toxic damages of blood-testis barrierr.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] 日吉徹: お茶の水医学会誌. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 寺田充彦: 病理と臨床. 7巻2号. 173-180 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 寺田充彦: 臨床泌尿器科. 42巻5号. 413-418 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 畠山茂: 病理と臨床. 7巻3号. 286-290 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 谷澤徹: 第78回日本病理学会誌. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 明石巧: 第78回日本病理学会誌. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shigeru Hatakeyama: ""Pathology of the Human Testis"in Functional Endocrine Pathology" Blackwell Scientific Publications Inc., 40 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 畠山茂: "病理学" 医歯薬出版, 100 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takahiko Terada: "Histopathology of the testis with male infertility" Byouri to Rynshou. 7. 173-180 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takahiko Terada: "Histopathological procedures treating surgical and biopsy materials -V. Testis-" Rynshou Hynyoukika. 42. 413-418 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shigeru Hatakeyama: "Organogenesis and development of the human testis" Byouri to Rynshou. 7. 286-290 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Touru Hiyoshi: "Demonstration of human autoantibody to Sertoli cells, and its immunopathological role in spermatogenic disorder" Ochanomizu Medical Journal. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Touru Tanizawa: "Autoantibody to basement membrane in human idiopathic spermatogenic disorder" Proceedings of 78th Japanese congress of Pathology. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shigeru Hatakeyama: "Pathology of the Human Testis" in Functional Endocrine Pathology. Blackwell Scientific Publications Inc., 40 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 日吉徹: お茶の水医学会誌. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 寺田充彦: 病理と臨床. 7巻2号. 173-180 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 寺田充彦: 臨床泌尿器科. 42巻5号. 413-418 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 畠山茂: 病理と臨床. 7巻3号. 286-290 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 谷澤徹: 第78回日本病理学会誌. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 明石巧: 第78回日本病理学会誌. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Shigeru Hatakeyama: ""Pathology of the Human Testis"in Functional Endocrine Pathology" Blackwell Scientific Publications Inc., 40 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 畠山茂: "病理学" 医歯薬出版, 100 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 畠山茂: 日病理会誌. 73. 3-29 (1984)

    • Related Report
      1987 Annual Research Report
  • [Publications] Shigeru Hatakeyama: ""Pathology of the Human Testis"in Functional Endocrine Pathology" Blackwell Scientific Publications Inc., 40 (1988)

    • Related Report
      1987 Annual Research Report

URL: 

Published: 1987-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi