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Potentiation of lethality and increase in body temperature by combined use of dmehamphetamine and morphine in mice.

Research Project

Project/Area Number 62480183
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Legal medicine
Research InstitutionOsaka University

Principal Investigator

FUNAHASHI Masumi (1988)  Osaka University Medical School Research Assistant, 医学部, 助手 (20135718)

四方 一郎 (1987)  大阪大学, 医学部, 教授 (10035371)

Co-Investigator(Kenkyū-buntansha) MATOBO Ryoji  Osaka University Medical School Associate Professor, 医学部, 助教授 (20107056)
舩橋 ますみ  大阪大学, 医学部, 助手 (20135718)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 1988: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1987: ¥4,000,000 (Direct Cost: ¥4,000,000)
Keywordsbody temperature / methamphetamine / morphine / naloxone / haloperidol / ketanserin / tolazoline / プロプラノロール / 生体アミン / ドーパミンレセプター / オピエートレセプター / マウス
Research Abstract

Lethality and change in body temperature in mice were examined after subcutaneous injection of d-methamphetamine and morphine alone or in combination. When a non-lethal dose of morphine (300 mg/kg) was administered with various doses of methamphetamine, the LD_<50> for methamphetamine was reduced to 5 mg/kg from 95 mg/kg. Injection of 5 mg/kg of methamphetamine produced slight hyperthermia, while 300 mg/kg of morphine decreased the body temperature of mice. However, when both drugs were used concomitantly, a marked increase in body temperature was observed. Those indicated a marked potentiation of toxicity by combined use of both drugs. We examined the effects of morphine antagonist (naloxone), dopamine antagonist (haloperidol), serotonine antagonist (ketanserin), -antagonist (tolazoline) and -antagonist (propranolol) on the hyperthermia induced by methamphetamine alone and methamphetamine plus morphine. The hyperthermia due to methamphetamine was completely abolished by pretreatment with haloperidol or ketanserin, but was conversely potentiated by pretreatment with naloxone. The hyper-thermia due to methamphetamine plus morphine abolished by pretreatment with naloxone, ketanserin or propranolol, but not haloperidol. When animals were pretreated with tolazoling these hyperthermia were still obserbed. These results suggest the participation of morphine receptors and some biogenic amines for the hyperthermia due to methamphetamine and morphine.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] Masumi,Funahashi: Forensic Science International. 37. 19-26 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Masumi, Funahashi: "Potentiation of lethality and increase in body temperture by combined use of d-methamphetamine and morphine in mice." Forensic Science International. 37. 19-26 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Masumi Funahashi: Forensic Science International.37. 19-26 (1988)

    • Related Report
      1988 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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