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Analysis of mechanism on gastrin biosynthesis and secretion

Research Project

Project/Area Number 62480197
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

KAWAI Keiichi  Kyoto Prefectural University of Medicine, 医学部, 教授 (50079745)

Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1988: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1987: ¥2,800,000 (Direct Cost: ¥2,800,000)
KeywordsGastrin / ガストリンーG / ガストリン-G / PAM活性 / オリゴヌクレオドプローベ
Research Abstract

Gastrin, one of well-known Gut hormon, stimulates gastric acid secretion and plays an important role in the pathogenesis of peptic ulcer.
In 1964 Gregory and Tracy isolated gastrin for the first time from antrum mucosa of pig stomach.
Gastrin is also one of polypeptide hormones that are alpha-amidated at the COOH-terminus. The precursor structure of gastrin at the amidation site is -Phe-Gly-Arg-Ser. Recently, COOH-terminal glycine extended progastrin (gastrin-G) were identified using radioimmunoassay with monoclonal antibody developed against a synthetic peptide analogue for progastrin, Tyr-Gly-Try-Met-Asp-Phe-Gly. Secretion and biosynthesis of gastrin-G were examined using the monoclonal antibody in the present study. Post-translational processing of gastrin might occur sequentially through proteolytic cleavage of progastrin to gastrin-G followed by activation via alpha-amidation. Gastrin-G co-existed with gastrin in antral gastrin cells, and co-secreted with gastrin in response to various stimulation from gastrin cells.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] 柳沢孝二,東健,河合隆,中島千春,井口秀人,川井啓市: 京都府立医科大学雑誌. 96. 715-717 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 東健,真神易,柳沢孝二,川井啓市: 日本消化器病学会雑誌. 84. 116 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takeshi Azuma;Keiichi Kawai;John M.Walsh: Gastroenterologia Japonica. 22. 685-689 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 川井啓市,東健: 京都府立医科大学雑誌. 97. 207-212 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 東健,川井啓市: 綜合臨床. 37. 367-374 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 東健,柳沢孝二,井口秀人,川井啓市: 日本消化器病学会雑誌. 84. 111 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 東健、河合隆、井口秀人、川井啓市: "消化管ホルモン" 医学図書出版, 737 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 藤田哲也、川井啓市: "消化器の発生と分化" 大阪書籍, 167 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takeshi,Azuma; Yasushi,Magami; Koji,Yanagisawa; Keiichi,Kawai: "The activity of peptidyl-glycine -amidating monooxigenase and gastrin" Japanese Journal of Gastroenterology. 84. 116 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takeshi,Azuma; Keiichi,Kawai; John H.,Walsh: "Immunocytochemical characterization of monoclonal antibody A_2B_5 in the rat gastric antrum" Gastroenterologia Japonica. 22. 685-689 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Keiichi,Kawai; Takeshi,Azuma: "Progress of the research in gastrin" Journal of Kyoto Prefectural University of Medicine. 97. 207-212 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takeshi,Azuma; Keiichi,Kawai: "Gastrin--its localization and physiological bioactivity and clinical understanding" Sogorinsho. 37. 367-374 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takeshi,Azuma; Koji,Yanagisawa; Hideto,Inokuchi; Keiichi,Kawai: "Amidation of gastrin" Japanese Journal of Gastroenterology. 84. 111 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takeshi Azuma.;Hideto Inokuchi.;Keiichi Kawai.: J.of Gastroenteralogy and Hepatology. 3. 349-354 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 藤田晢也,川井啓市: "消化器の発生と分化" 大阪書籍, 167- (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 柳沢孝二;東健;河合隆;中島千春;井口秀人;川井啓市: 京都府立医科大学雑誌. 96. 715-717 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 東健;真神易;柳沢孝二;川井啓市: 日本消化器病学会雑誌. 84. 116 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Takeshi Afuma;Keiichi Kawai;John H.Walsh: Gastroenterologia Japonica. 22. 685-689 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 川井啓市;東健: 京都府立医科大学雑誌. 97. 207-212 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 東健;川井啓市: 綜合臨床. 37. 367-374 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] 東健;柳沢孝二;井口秀人;川井啓市: 日本消化器病学会雑誌. 84. 111 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 東健;河合隆;井口秀人;川井啓市: "消化管ホルモン(VII)" 医学図書出版株式会社, 737 (1987)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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