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Morphometric analysis of primary sensory neuron in aged rats

Research Project

Project/Area Number 62480209
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

OHNISHI Akio  Univ. of Occup. & Environm. Hlth. Associate Professor, 医学部・神経内科, 助教授 (50091278)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Tatsunori  Univ. of Occup. & Environm. Hlth. Assistant, 医学部・神経内科, 助手 (10166803)
ITOYAMA Yasuto  Kyushu Univ. Associate Professor, 医学部・神経内科, 助教授 (30136428)
MURAI Yoshiyuki  Univ. of Occup. & Environm. Hlth. Professor, 医学部・神経内科, 教授 (80038637)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥4,300,000 (Direct Cost: ¥4,300,000)
KeywordsPrimary sensory neuron / Aged rat / Nerve terminal / Myelinated fiber / Unmyelinated fiber / ニュ-ロペプタイド / 第一次感覚ニューロン / ニューロペプタイド
Research Abstract

In the comparative morphometric studies of the primary sensory neuron between young and old rats, the following conclusions were obtained. In older rats compared with younger rats, 1)the number of myelinated fibers was decreased, 2)the myelin sheath showed segmental demyelination followed by remyelination, 3)the myelin change was severe in the ventral root, 4)axonal degeneration of the myelinated fiber was more frequently found, 5)the nerve cell body in the spinal dorsal root ganglion showed higher density and shrinkage of the cytoplasm, 6)axonal swellings and spheroids were frequently found in the gracile nucleus of the medulla, but they were rare in the dorsal born of the lumbar spinal cord and in the dorsal nucleus of clarke of the first lumbar spinal cord, 7)the volume density of the nerve terminal was decreased in the gracile nucleus of the medulla, dorsal born of the lumbar spinal cord and dorsal nucleus of clarke of the first lumbar spinal cord, and the decrease was prominent in the gracile nucleus, 8)the total number of nerve cell bodies in the first sacral dorsal root ganglion was decreased, and the decrease of those with larger diameters was prominent, and 9)the unmyelinated fibers showed the tendency of the decrease in number, but the ongoing degenerative findings of unmyelinated fibers were not found. Therefore, it was concluded that the primary sensory neuron shows histopathological alterations in each component of the myelin sheath, axon, nerve terminal and nerve cell body. The large diameter sensory neuron seems to be most vulnerable in the aging process.

Report

(3 results)
  • 1989 Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 大西晃生,村井由之,糸山泰人,山本辰紀: "加齢ラットの第一次感覚ニュ-ロン 若年ラットとの対比" 臨床神経学(予定).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大西晃生,村井由之,糸山泰人,山本辰紀: "加齢ラットの軸索萎縮" 神経病理学(予定).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大西晃生,村井由之,糸山泰人,山本辰紀: "加齢ラットのニュ-ロピル病変" 神経病理学(予定).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大西晃生,村井由之,糸山泰人,山本辰紀: "Morphometric difference of nerve cell bodies in spinal dorsal root ganglion between young and aged rats." Brain Research(予定).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohnishi A, Murai Y, Itoyama Y, Yamamoto T: "Primary sensory neuron in aged rats" Clinical Neurology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohnishi A, Murai Y, Itoyama Y, Yamamoto T: "Axonal atrophy in aged rats" Neuropathology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohnishi A, Murai Y, Itoyama Y, Yamamoto T: "Pathological findings of the neuropile in aged rats" Neuropathology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohnishi A, Murai Y, Itoyama Y, Yamamoto T: "Morphometric difference of nerve cell bodies in spinal dorsal root ganglion between young and aged rats" Brain Research.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大西晃生、村井由之、糸山泰人、山本辰紀: 臨床神経学.

    • Related Report
      1988 Annual Research Report
  • [Publications] 大西晃生、村井由之、糸山泰人、山本辰紀: 神経病理学.

    • Related Report
      1988 Annual Research Report
  • [Publications] 大西晃生、村井由之、糸山泰人、山本辰紀: 神経病理学.

    • Related Report
      1988 Annual Research Report
  • [Publications] 大西晃生、村井由之、糸山泰人、山本辰紀: Brain Research.

    • Related Report
      1988 Annual Research Report
  • [Publications] 大西晃生;村井由之;糸山泰人;山本辰紀: 臨床神経学.

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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