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A study on entrainment; with special reference to the continuation mechanism of tachycardia

Research Project

Project/Area Number 62480219
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionSaitama Medical School

Principal Investigator

MATSUO Hiroshi  Saitama Medical School, Professor, 医学部, 教授 (60010378)

Co-Investigator(Kenkyū-buntansha) SEGAWA Kazuhiko  Saitama Medical School, Assistant, 医学部, 助手 (00179318)
TANAKA Shugo  Saitama Medical School, Assistant Professor, 医学部, 講師 (90179755)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥4,300,000 (Direct Cost: ¥4,300,000)
KeywordsEntrainment / Reentry / Concealed WPW syndrome / Atrial flutter / Slow conduction area / 興奮旋回
Research Abstract

As one of the criteria of entrainment, Wellens has proposed that after cessation of pacing, the first tachycardia complex occurs at the pacing rate. This is not always so, depending upon the pacing site on the macro reentrant circuit. The first tachycardia cycle length prolongs before returning to the original tachycardia cycle length. In order to see why and how this occurs, we have studied the change of cycle length at each electrogram-recording site during and immediately after pacing in A-V reentrant tachycardia of concealed WPW syndrome and experimental atrial flutter of dog.
In A-V reentrant tachycardia, prolongation of the first tachycardia cycle length necessitates the presence of slow conduction area (SCA),e.g. AV node, in the reentrant circuit. The degree of prolongation equals to the difference of conduction times through SCA during pacing and tachycardia. On pacing from proximal site to SCA (high right atrium), low right atrium, seated proximal to SCA but downstream to pacing site, shows the prolongation. On pacing from distal site to SCA (right vantricle), all recording sites show the prolongation, because these sites lie downstream to the pacing site.
In experimental atrial flutter, however, atrial excitation sequence, constructed by 7 local atrial electrograms, differs slightly during atrial premature stimulation and tachycardia. The failure of precise stimulation of reentry circuit (mother ring) or contrnuously changing of the route of the circuit could be the underlying mechanism. The presence of SCA could not be identified in experimental atrial flutter.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] 松尾博司,井上博: 心臓. 15. 259-269 (1983)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 松尾博司,野崎影,井上博: 心電図. 5. 3-15 (1985)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] A.Nozaki;H.Matsuo;H.Inoue;T.Sugimoto: Japanese Circulation Journal. 50. 91-98 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 松尾博司: 心臓. 19. 642-653 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 松尾博司: 循環器科. 22. 519-528 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 松尾博司: 埼玉医科大学雑誌. 15. 73-73 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 松尾博司: "不整脈診療マニュアル" 新興医学出版社, 76 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 松尾博司,杉本恒明: "臨床心臓電気生理学(心房細動・心房粗動)" 南江堂, 403 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hiroshi,Inoue; Hiroshi,Matsuo; Kan,Takayanagi; Satoru,Murao: "Clinical and experimental studies of the effects of atrial extrastimulation and rapid pacing on atrial flutter cycle" American Journal of Cardiology. 48. 623-631 (1981)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hiroshi,Inoue; Kiyoshi,Inoue; Hiroshi,Matsuo; Koichi,Kuwaki; Tetsuro,Shirai; Satoru,Murao: "Resetting of tachycardia cycle by single and double ventricular extrastimuli in recurrent sustained ventricular tachycardia" Pace. 7. 3-9 (1984)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hiroshi,Matsuo; Hiroshi,Inoue; Tsuneaki,Sugimoto: "Differential effects of premature atrial stimulation on cycle lengths in macrore-entrant and ectopic tachycardias" Circulation. 70. 11-223 (1984)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Akira,Nozaki; Hiroshi,Matsuo; Hiroshi,Inoue; Tsuneaki,Sugimoto: "A study on entrainment in various forms of tachycardia" Japanese Circulation Journal. 50. 91-98 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hiroshi,Matsuo; Nobuo,Yoshimoto; Shugo,Tanaka; Naondo,Takido; Kazuhiko,Segawa: "Prolongation of the first post-pacing cycle length in entrainment" Japanese Circulation Journal. 51. 727-727 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 松尾博司、井上博: 心臓. 15. 259-269 (1983)

    • Related Report
      1988 Annual Research Report
  • [Publications] 松尾博、野崎彰、井上博: 心電図. 5. 3-15 (1985)

    • Related Report
      1988 Annual Research Report
  • [Publications] A Nozaki,;H Matsuo,;H Inoue,;T Sugimoto,: Japanese Circulation Journal. 50. 91-98 (1986)

    • Related Report
      1988 Annual Research Report
  • [Publications] 松尾博司: 心臓. 19. 642-653 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] 松尾博司: 循環器科. 22. 519-528 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] 松尾博司: 埼玉医科大学雑誌. 15. 73-73 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 松尾博司: "不整脈診療マニュアル" 新興医学出版社, 76 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 松尾博司、杉本恒明: "臨床心臓電気生理学(心房細動・心房粗動)" 南江堂, 403 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 松尾博司: 心臓. 15. 259-269 (1983)

    • Related Report
      1987 Annual Research Report
  • [Publications] 松尾博司: 心電図. 5. 3-15 (1985)

    • Related Report
      1987 Annual Research Report
  • [Publications] 松尾博司: 心臓. 19. 642-653 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 松尾博司: 循環器科. 22. 519-528 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 松尾博司: 埼玉医科大学雑誌. 15. 73-73 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] 松尾博司: "不整脈診療マニュアル" 新興医学出版社, 76 (1988)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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