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Experimental and clinical analysis of functional characteristics of intramyocardial microvessls and its disorders

Research Project

Project/Area Number 62480220
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKawasaki Medical School

Principal Investigator

KAJIYA Fumiko  Kawasaki Medical School, Professor, 医用工学, 教授 (70029114)

Co-Investigator(Kenkyū-buntansha) YAGINUMA Toshio  Jichi Medical School, Professor, 循環器内科, 教授 (00048985)
MITO Keiichiro  Kawasaki College, Associate Professor, 助教授 (40078027)
OGASAWARA Yasuo  Kawasaki Medical School, Lecturer, 医用工学, 講師 (10152365)
TSUJIOKA Katsuhiko  Kawasaki Medical School, Associate Professor, 医用工学, 助教授 (30163801)
FUJIWARA Takashi  Kawasaki Medical School, Professor, 心臓外科, 教授 (90090224)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1988: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1987: ¥4,000,000 (Direct Cost: ¥4,000,000)
KeywordsIntramyocardial blood flow / microcirculation / optical fiber laser Doppler velocimeter / high frequency ultrasound Doppler velocimeter / 心筋肉容量血管 / 心筋内血流 / 心筋内容量血管
Research Abstract

The purpose of this study was to clarify the physiological and pathophysiological role of intramyocardial capacitance vessels in the regulation of coronary circulation in animal experiment and clinical research. In anesthetized open-chest dogs coronary inflow(artery flow) coronary outflow(coronary vein flow) were measured by an optical fiber laser doppler velocimeter under control of coronary perfusion pressure. On the other hand, human coronary artery and vein flows were measured by an 80 channel 20 MHz ultrasound doppler velocimeter during cardiac surgery.
Functional characteristics of intramyocardial capacitance vessels were composed of two factors: unstressed volumes(UV) and usual compliance. The characteristics of UV is fitted to store blood and its capacity is found to be 5ml/100g of LV. The coronary inflow resistance increased without significant changes of zero-flow pressure, when UV was filled with blood. The phasic coronary vein flow was mainly regulated by the blood stored within intramyocardial vessels. The rheological property of blood had effects on not only inflow resistance but also zero-flow pressure of the coronary artery. The fluid dynamics of the human poststenotic coronary artery folw was analyzed by 20MHz 80 Channel ultrasound Doppler velocimeter during cardiac surgery. the phasic characteristics of coronary artery folw in pressure overload human hypertrophy was also clarified. We developped dual-core optical fiber laser doppler velocimeter, which is useful for the measurement of blood flow away from the fiber and disturbed flow.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] F.Kajiya;et al.: Med.Prog.Technol.12. 77-85 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] F.Kajiya;et al: Circulation. 76(5). 1092-1100 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] F.Kajiya;et al: Biorheology. 25. 227-235 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] D.Kilpatric,et al: Australian Physical & Engineering Sciences in Medicine. 11(1). 5-14 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] F.Kajiya;et al.: Cardiovasc.Res.22(8). 545-554 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T.Fujiwara;et al.: Circulation. 78(5). 1210-1217 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] F.Kajiya;et al: "Role of blood flow in atherogenesis" Intraoperative evaluation of blood velocit waveforms in different coronary artery bypass graft., 117-122 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] F. Kajiya, et al.: "An optical-fiber laser Doppler velocimeter and its application to measurements of coronary blood flow velocities." Med. Prog. Technol.12. 77-85 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] F. Kajiya, et al.: "Analysis of flow characteristics in poststenotic regions of the human coronary artery during bypass graft surgery." Circulation. 76(5). 1092-1100 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] F. Kajiya, et al.: "Dual-fiber laser Doppler velocimeter and its application to the measurements of coronary blood velocity." Biorheology. 25. 227-235 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] F. Kajiya, et al.: "Effect of packed cell volume on diastolic coronary artery pressure-flow relations in the dog." Cardiovascuc. Res.22(8). 545-554 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T. Fujiwara, et al.: "Comparison of blood-flow velocity waveforms in different coronary artery bypass grafts --- Sequential saphenous vein grafts and internal mammary artery grafts---." Circulation. 78(5). 1210-1217 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] F. Kajiya, et al.: Intraoperative evaluation of blood velocity waveforms in different coronary artery bypass graft.Springer-Verlag, 117-122 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] F.Kajiya,et al.: Circulation. 25. 227-235 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] D.Kilpatrick,et al.: Australian Physical&Engineering Sciences in Medicine. 11(1). 5-14 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] F.Kajiya,et al.: Cardiovasc.Res.22(8). 545-554 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Fujiwara,et al.: Circulation. 78(5). 1210-1217 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Mito,et al.: "Microcirculation in Circulatory Disorders" Evaluation of blood flow velocity waveforms in intramyocardial artery and vein by laser Doppler velocimeter with an optical fiber., 525 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] F.Kajiya,et al.: "Microcirculaion in Circulatory Disorders" Flow characteristics in poststenotic regions of the human coronary artery assessed by 20-MHz 80-channel pulsed Doppler velocimetry., 315 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 梶谷文彦;小笠原康夫;辻岡克彦: BME. 1. 34-40 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 金沢成雄;藤原巍;稲田洋;野上厚志;山根尚慶;近藤潤次;勝村達喜;梶谷文彦: 日本心臓血管外科学会雑誌. 17. 199-200 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] F.Kajiya;O.Hiramatsu;K.Mito;Y.Ogasawara;K.Tsujioka: Medical Progress through Technology. 12. 77-85 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] F.Kajiya;K.Tsujioka,et al.: Circulation. 76. 1092-1100 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] F.Kajiya;O.Hiramatsu;Y.Ogasawara;K.Mito;K.Tsujioka: Biorheology.

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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