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Characterization of Tumor Vasculature to Specify Cancer Therapy

Research Project

Project/Area Number 62480238
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionFukui Medical School

Principal Investigator

ISHII Yasushi  Fukui Medical School, 医学部, 教授 (00026949)

Co-Investigator(Kenkyū-buntansha) NAKASHIMA Tetsuo  Fukui Medical School, 医学部, 助手 (70188936)
NAKATSUGAWA Shigekazu  Fukui Medical School, 医学部, 講師 (00180315)
ODORI Teruo  Fukui Medical School, 医学部, 助教授 (10115818)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 1988: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1987: ¥4,800,000 (Direct Cost: ¥4,800,000)
KeywordsImaging diagnosis / RF capacitive heating / Thermotheraphy / Dynamic Phantom / MR diffusion imaging / 31-P MR spectroscopy / ^<31>P-MRS / 嫌気性エネルギー代謝 / diffusion imaging / ^<31>PーMRS / 癌の治療 / 腫瘍血管 / 微小循環 / MRスペクトロスコピー / XTV造影
Research Abstract

The aim of this project is to establish the effect of abnormal constitution of tumor vascularure on dynamic flow/volume relation and subsequent metabolic state. In this connection, we have investigated following four themes.
1) A battery of clinical examination such as angiography, dynamic contrast enhanced CT and radionuclide estudies using flow tracer as well as tumorseeking agents were done, in patients with malignant tumor. Data of these examinations revealed decreased tendeney of flow/volume relation in the tumor with increasing its size and with tumor sequestration of the radiotracer.
2) Since heat accumulation within tumor due to the decreased flow/volume ratio might be plausible, in the hyperthermia therapy using RF capacitive heating, we validated this assumption using simulated dynamic phantom study.
3) In order to establish the rational scheme for cancer control such as thermotherapy, imaging of this perfusion status with highly precision seems to be necessary. So, an attempt to image diffusion or microcirculation were successfuly accomplished using MR imaging modality.
4) The lowered tendeney of perfusion status in the malignant tumor with increasing size was proved to cause anerobic energy production as evidence by the 31-P-MR Spectroscopy.
5) In conclusion, anatomical derangement of the tumor vasculature causes metabolic change through decreased efficiency of the perfusion status (flow/volume relation). Thus adequate means for perfusion imaging such as diffusion imaging may play a key role to establish an adequate strategy for the cancer control.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 玉川洋一: 日本磁気共医学会雑誌. 9. 163 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 木村浩彦: 日本磁気共鳴医学会雑誌. 9. 284 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ryosuke Okumura: Proceedings of 7th Annual Meeting of SMRM. 1. 541 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 中津川重一: 日本医学放射線学会生物部会誌. 1. 93-96 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Teruo Odori: Proceedings of 4th Asia & Oceania Congress of Nuclear Medicine. 1. 309-310 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 周藤裕治: 核医学. 25. 455-458 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Y. Tamagawa, et al: "IVIM imaging using 2T small bore MR." Jap. J. Magnet. Reson. in Med.9. 163 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] H. Kimura, et al: "^<31>P MRS findings of human lung cancer implanted on nude mouse." Jap. J. Magnet. Reson. in Med.9. 284 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] R. Okumura, et al: "Evaluation of the signal intensity in replated scan after administration of Gd-DTPA." Proceedings of 7th Annual Meeting of SMRM. 1. 541 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] S. Nakatsugawa, et al: "Influence of perfusion on RF capacitive heating -- Dynamic phantom" Nippon Acta Radiologica, Biology. 1. 93-96 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T. Odori, et al: "The effect of vascularity on tumor uptake of ^<99m>Tc (V) dimercaptosuccinic acid (DMS)." Proceedings of 4th Asia & Oceanic Congress of Nuclear Medicine. 1. 309-310 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Y. Suto, et al: "Initial Traials of Hepatic Imaging Using I-123-IMP." The Japanese Society of Nuclear Medicine. 25. 455-458 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 玉川洋一: 日本磁気共医学会雑誌. 9. 163 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 木村浩彦: 日本磁気共鳴医学会雑誌. 9. 284 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ryosuke Okumura: Proceedings of 7th Annual Meeting of SMRM. 1. 541 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 中津川重一: 日本医学放射線学会生物部会誌. 1. 93-96 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Teruo Odori: Proceedings of 4th Asia & Oceania Congress of Nuclear Medicine. 1. 309-310 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 周藤裕治: 核医学. 25. 455-458 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] S.Nakatsugawa: Radiosensitization Newsletter,Chemical Modifiers & Hyperthermia. 6. 5-8 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 中津川重一: 日本癌治療学会誌.

    • Related Report
      1987 Annual Research Report
  • [Publications] 伊藤俊祐: Therapeutic Research. 6. 1041-1047 (1987)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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