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Synergistic effect of the cell-kinetic oriented chemo-endocrine therapy on mammary cancer.

Research Project

Project/Area Number 62480273
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionFukushima Medical College

Principal Investigator

ABE Rikiya  Professor, 第二外科, 教授 (70004629)

Co-Investigator(Kenkyū-buntansha) KIMIJIMA Izo  Assistant, 第二外科, 助手 (00161547)
TSUCHIYA Atsuo  Associate professor, 第二外科, 助教授 (10117674)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsTMX / Testectomy / 5FU / chemo-endocrine therapy / Breast cancer / FCM / 細胞動態 / フローサイトメトリー / TMX,除睾術 / 5FU / MCF7 / 内分泌治療 / 細胞四粒 / フローサイトメトメトリー / TAM
Research Abstract

Two types of breast cancer MCF7 and SC115 were used in vitro and in vivo experment respectively. MCF7 culturing in vitro was estrogen dependent human breast cancer cell line. BC115 maintaining on DDS male mice was androgen dependent breast cancer. Tamoxifen was administered in vitro and testectomy was carriedtout in vivo as the endocrine therapy. 5FU was used 1 g/ml in vitro and 40mg/kg in vivo as the chemotherapy. Cell kinetics of each tumor were analysed with flow cytometry.
Both of tamoxifen and testectomy reduced tumor growth. These effects of the endocrine therapy upon the tumor cell kinetics were thought to be g_1 block. The effect of 5FU upon the tumor cell kinetics was obtained in temporary S phase depression.
Synergistic inhibitory effect of the chemoendocrine therapy on BC115 growth in DDS mice were observed in comparing with three groups which divided by 5FU administration at the different times before, 1 week, 2 weeks after testectomy performed. Anteceding administration of 5FU showed the synergistic inbitory effect on tumor growth. This inbitory effect resulted cytometrically from the long term depression of S phase fraction.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Rikiya,Abe: The Journal of Steroid Biochemistry. 28. 142 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 土屋敦雄: 癌の臨床. 35. 30-34 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Rikiya,Abe: "Experimentol studies on enhanced effects of chemo endocrine therapy for breast cancer" The Journal of Steroid Biochemistry. 28. 142 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Atsuo,Tsuchiya: "DNA analysis by flow cytometry in breast carcinoma" Japanese Journal of Cancer Clinics. 35. 30-34 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 土屋敦雄: 癌の臨床. 35. 30-34 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Rikiya Abe: The Journal of Steroid Biochemistry.28. 142 (1987)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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