• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study of a new treatment using excimer laser for severe ischemic heart disease

Research Project

Project/Area Number 62480293
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionKyoto University

Principal Investigator

BAN Toshihiko  Kyoto University, Faculty of medicine professor Department of Candiovascular Surgery, 医学部, 教授 (00173120)

Co-Investigator(Kenkyū-buntansha) OKABAYASHI Hitoshi  Kyoto University, Faculty of medicine assistant Department of Candiovascular Sur, 医学部, 助手 (10204009)
OKAMOTO Yoshihumi  Kyoto University, Faculty of medicine assistant professor Department of Candiova, 医学部, 助教授 (80116392)
松田 捷彦  京都大学, 医学部, 助手 (70127140)
Project Period (FY) 1987 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥4,800,000 (Direct Cost: ¥4,800,000)
KeywordsExcimer Laser / XeCl / Laser Angioplasty / Laser Endarterectomy / Ischemic Heart Disease / Vaporization / Thermal Injury / Quartz Fiber / エキシマレーザー / 塩化キセノン / フッ化クリプトン / 血管形成術 / 石英ファイバー / KrF / Xecl / 心筋穿刺法
Research Abstract

We studied the possible application of excimer laser to ischemic heart disease. In the first experiment, we studied the ablative effects of excimer laser at the wavelengths of 248 nm and 308 nm on the pig myocardium. Very clear cuts could be observed by histological examination, but there was a small adjacent line produced by thermal effect. A wavelength of 248 nm had less thermal effect than a wavelength of 308 nm. In addition we coupled the excimer laser to an optical fiber and measured the laser energy transmitted through the fiber. At a wavelength of 248 nm , the fibertip was destroyed. In the second experiment, we examined effects of excimer laser irradiation on blood. The lysis of erythrocytes does not occur in the laser - exposed cells. However, the damage to erythrocyte membrane took place as it was evidenced by progressive hemoglobin leakage into plasma. In the third experiment, we carried out a study on the possible application of the excimer laser in laser angioplasty. The healing responses following irradiation of the excimer laser to normal canine artery was satisfactory. Laser angioplasty was performed in 4 totally occluded femoral arteries in mongrel dogs using the excimer laser (XeCl : 308nm). The arteries were successfully recanalized in all 4 arteries using 2.5 - 6 m J/pulse, 20 - 30 pps and 6000 shots. Additionally, 4 WHHL rabbits were used in laser endarterectomy.
Histological examination of all laser - irradiated arteries revealed favorable results with no signs of the thermal injury and no thrombus formation. The results suggest the applicability of excimer laser to ischemic heart disease.

Report

(4 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] 岡林均: "心臓血管外科領域におけるレ-ザ-の応用に関する基礎的研究" 日本レ-ザ-医学会誌. 9. 25-28 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 岡林均: "CO_2レ-ザ-を用いた微小血管吻合-縫合法との比較、高脂血症ウサギでの検討-" 脈管学. 29. 1177-1181 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 岡林均: "エキシマレ-ザ-の血液に対する影響" 日本レ-ザ-医学会誌. 10. 331-333 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 岡林均: "エキシマレ-ザ-を用いたLaser Angioplasty" 日本レ-ザ-医学会誌. 10. 125-127 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 岡林均: "エキシマレ-ザ-照射後の犬正常動脈壁の治癒過程に関する研究" 日本心臓血管外科学会誌(発表予定).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okabayashi Hitoshi: "Experimental Study of Application of laser to Cardiovascular Surgery" J. Jpn. Society Laser Medicine 9, 1988, 25-28.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okabayashi Hitoshi: "Carbon Dioxide Laser-assisted Microvascular Anastomosis" J. Jpn. Coll, Angiol 29, 1989.1177-1181.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okabayashi Hitoshi: "Effects of Excimer Laser Irradiation on Blood" J. Jpn. Society laser Medicine 10, 1989, 331-333.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okabayashi Hitoshi: "Excimer laser Angioplasty" J. Jpn. Society laser Medicine 10, 1989, 125-127.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Okabayashi Hitoshi: "Healing Responses Following Irradiation of Excimer Laser to Normal Canine Artery" J. Jpn. Cardiorasc, Surg.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 岡林均: "心臓血管外科領域におけるレ-ザ-の応用に関する基礎的研究" 日本レ-ザ-医学会誌. 9. 25-28 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 岡林均: "CO_2レ-ザ-を用いた微小血管吻合-縫合法との比較、高脂血症ウサギでの検討-" 脈管学. 29. 1177-1181 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 岡林均: "エキシマレ-ザ-の血液に対する影響" 日本レ-ザ-医学会誌. 10. 331-333 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 岡林均: "エキシマレ-ザ-を用いたLaser Angioplasty" 日本レ-ザ-医学会誌. 10. 125-127 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 岡林均: "エキシマレ-ザ-照射後の犬正常動脈壁の治癒過程に関する研究" 日本心臓血管外科学会誌.

    • Related Report
      1989 Annual Research Report

URL: 

Published: 1987-04-01   Modified: 2017-10-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi