| Project/Area Number |
62480297
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Saitama Medical University (1988-1989)
Jichi Medical University (1987) |
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Principal Investigator |
KIMURA Sosuke Saitama Medical School, Dept. of Surgery, Associate Prof., 医学部, 助教授 (30118450)
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| Co-Investigator(Kenkyū-buntansha) |
ADACHI Hideo Saitama Medical School, Dept. of Surgery, Assistant Prof., 医学部, 講師 (80175174)
堀見 博之 自治医科大学, 胸部外科, 助手 (10167637)
長谷川 嗣夫 自治医科大学, 胸部外科, 教授 (30048954)
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| Project Period (FY) |
1987 – 1989
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥4,900,000 (Direct Cost: ¥4,900,000)
Fiscal Year 1989: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1988: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1987: ¥2,700,000 (Direct Cost: ¥2,700,000)
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| Keywords | ECMO / Extreme small premature infant / Respiratory Distress Syndrome. / 呼吸不全 / IRDS |
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| Research Abstract |
With of maximum sophisticated supportive care, the survival expectation of premature infants with the body weight of under 1000g is still very low. This project aims to develope a new system of extra-corporeal membrane oxygenation(ECMO), possible for those premature infants of body weight under 1000g or gestational age of below 30 weeks.
This system, "Two-Staged Oxygenation" method, consists of two circuits, possessing the primary small circuit of ECMO and the secondary large external circuit of conventional cardio-pulmonary bypass system using artificial blood. The external circulation, controlled by the conventional cardio-pulmonary bypass system, oxygenates the infant's blood under the fluid-to-fluid oxygen transport method, and at the same keeps the temperature at the certain level. The primary circuit needs the priming volume of only 30 ml, and its flow is controlled by servomatic method with a small roller pump.
After the basical Experiments, this system is found to have a very high potential of clinical use, namely small priming volume, heat exchange function included, and totally small size(the primary circuit).
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