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Experimental Research of Pathophisiology and Treatment of Cerebral Vasospasm in Rabbit Model with Neurologic Symptoms, - The Effect of Elastase Substance Administration -

Research Project

Project/Area Number 62480306
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionToyama Medical and Pharmaceutical University

Principal Investigator

ENDO Shunro  Toyama Medical Pharmaceutical University, Department of Neurosurgery, Associated Professor, 医学部, 助教授 (70125269)

Co-Investigator(Kenkyū-buntansha) KUWAYAMA Naoya  Toyama Medical Pharmaceutical University, Department of Neurosurgery, Research A, 医学部, 助手 (30178157)
FUKUDA Osamu  Toyama Medical Pharmaceutical University Department of Neurosurgery, Research As, 医学部, 助手 (10208952)
OHTSUJI Tsuneo  Toyama Medical Pharmaceutical University, Department of Neurosurgery, Research A, 附属病院, 助手 (60152188)
Project Period (FY) 1987 – 1989
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1989: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1988: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1987: ¥2,600,000 (Direct Cost: ¥2,600,000)
KeywordsCerebral Vasospasm / Animal Experimental Model / Neurologic symptoms / Cerebral Blood Flow / Elastase Substance / エラスターゼ製剤
Research Abstract

*Experimental model of symptomatic vasospasm and investigations of cerebral blood flow, sensory evoked potetial (SEP) and pathologic findings : The common carotid arteries were ligated bilaterally 2 weeks before twice induction of subarachnoiu hemorrhage in rabbits. Rabbits showed a progressing neurologic deficit that was worst on the fourth or fifth day after the subarachnoid hemorrhage. On the fourth day after the subarachnoid hemorrhage, the cortical blood flow showed 20-30% reduction in symptomatic rabbits in comparison with normal ones. SEP also showed nearly changes. In pathological investigations, Characteristic findings of vasospasm were observed on the basilal artery of symptomatic rabbits. However, the infraction changes of cerbral tissues were minimum.
Presumably, the rabbits became symptomatic because they no longer had collateral blood flow to compensate for the reduced blood flow in the basilar artery after subarachnoid hemorrhage. This model of symptomatic vasospasm may be beneficial for future studies. We are now trying to make a new model with more serious symptoms.
*The effect of elastase administration : For the protection of symptomatic vasospasm, the effect of elastase substance that prevents the damage of elastic layers was expected. In this seriese, the administration of elastase substances in various amounts and methods were experimented. The results were almost negative. The combined treatment with other materials are investigating now.

Report

(4 results)
  • 1990 Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Shunro Endo et.al.: "Experimental Model of Symptomatic Vasospasm in Rabbits" Stroke. 19. 1420-1425 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ryosei Iwai,Shunoro Endo et.al.: "Relation of Supersensitivity to CerebralVasospasm induced by Oxyhemoglobin" Neurological Research. 10. 169-174 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Shunro Endo et.al.: "Cerebral Blood Flow in Experimental Model of Symptomatic Vasospasm" Stroke.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Shunro Endo et. al: "Experimental Model of Symptomatic Vasospasm in Rabbits" Stroke. 19. 1420-1425 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ryosei Iwai, Shunro Endo et. al.: "Relation of Supersensitivity to Cerebral Vasospasm induced by Oxyhemoglobin" Neurological Research. 10. 169-174 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Shunro Endo et.al.: "Cerebral Blood Flow in Experimental Model of Symptomatic Vasospasm." Stroke.

    • Related Report
      1989 Annual Research Report
  • [Publications] Shunro,Endo;et al: Stroke. 19. 1420-1425 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Rhosei,Iwai;Shunro,Endo;et al: Neurological Research. 10. 169-174 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Shunro,Endo;et al: Stroke.

    • Related Report
      1988 Annual Research Report
  • [Publications] Shunro Endo: Stroke.

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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