The influence of degranulation by antigen specific IgG and IgG_4 antibody in nasal allergy patient.
| Project/Area Number |
62480358
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Nagoya City University, Medical School |
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Principal Investigator |
ITO Hirotaka Nagoya city university, Medical school,associate professor, 医学部, 助教授 (60080115)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSHITA Takashi Nagoya city university, Medical school, assistant, 医学部, 助手 (90181718)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Nasal allergy / 脱顆粒 / 好酸球 / アレルギー性鼻炎 / ペルオキシダーゼ / アリルスルファターゼ / アルカリフォスファターゼ / 抗原特異IsG / IgG_4 |
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| Research Abstract |
Eosinophils are found in the nasal discharge of patients with allergic rhinitis. They are well known to release many kinds of chemical mediators by the antigen challenge. Using anti-peroxidase antibody and Protein A-gold, we try to stain the peroxidase granules in the eosinophils and examine possible influence of the allergic attack and its treatment. From these study, we obtain the result that the granules in the eosinophils change to four types by the attack and the treatment.
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Report
(3 results)
Research Products
(8 results)
