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The effects of local factors on bone remodeling

Research Project

Project/Area Number 62480371
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Morphological basic dentistry
Research InstitutionMeikai University

Principal Investigator

KUMEGAWA Masayoshi  Meikai University School of Dentistry, 歯学部, 教授 (40049367)

Co-Investigator(Kenkyū-buntansha) KURIHARA Eiko  Meikai University School of Dentistry, 歯学部, 助手 (40112643)
HAKEDA Yoshiyuki  Meikai University School of Dentistry, 歯学部, 助手 (90164772)
MAEDA Norihiko  Meikai University School of Dentistry, 歯学部, 講師 (60049418)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1988: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1987: ¥3,000,000 (Direct Cost: ¥3,000,000)
KeywordsOsteoblasts / Osteoclasts / 局所因子 / 骨茅細胞
Research Abstract

We established a new culture system for osteoclast formation from 5-fluorouracil-treated mouse spleen cells unsupported by osteoblastic cells (Kurihara et al. Blood in press). Using this system we examined the effects of factors or osteoblastic cells on osteoblastic cell formation. The results obtained were as follows. Vitamin D_3, parathyroid hormone, glucorticoids. Prostaglandin (PG) F_<2 >, IL-1( ) and SGF stimulated osteoclast formation, whereas TGF- , PGE_1 and PGE_2 inhibited the formation (Sumitani et al. Endocrinology in preparation). Osteoblastic cells were involved in osteoclast formation: undifferentiated osteoblastic cells inhibited the formation. While differentiated ones stimulated it (Hiura et al. Endocrinology in prerparation). Osteoblastic celis mediated the action of TGF- and vitamin D_3 to the precursors for osteoclasts. IL-1( ) acted also MC3T3-El cells (Ikeda et al. Calcif. Tissue Int.).

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Y.Hakeda;T.Hotta;N.Kurihara;E.lkeda;N.Maeda;Y.Yagyu.M.Kumegawa: Endocrinology. 121. 1966-1974 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] N.Kurihara;T.Suda;Y.Miura;H.Kodama;M.Kumegawa: Blood in press.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] S.Ishizuka;N.Kurihara;Y.Hakeda;N.Maeda;K.Ikeda;M.Kumegawa;Anthony W.Norman: Endocrinology. 123. 781-786 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K.Hiura;K.Sumitani;T.Kawata;K.Higashino;E.Kurihara;T.Sato;Y.Hakeda;M.Kumegawa: Endocrinology.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] E.Ikeda;M.Kusaka;Y.Hakeda;K.Yokota;M.Kumegawa;S.Yamamoto: Calcif.Tissue int.43. 162-166 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yoshiyuki,Hakeda; Takahiko,Hotta; Noriyoshi,Kurihara; Eiko,Ikeda; Norihiko,Maeda; Yoshihiro,Yagyu; Masayoshi,Kumegawa: "Prostaglandin E<@D21@>D1 and F<@D22alpha@>D2 Stimulate Differentiation and Proliferation,Reapectirely, of Clonal Osteoblastic MC3T3-E1 Cell by Different Second Messenger in Vitro*" Endocrinology. 121. 1966-1974 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Noriyoshi,Kurihara; Toshio,Suda; Yasusada,Miura; Hiroaki,Kodama; Masayoshi,Kumegawa: "Generation of Osteoclasts from Hemopoietic Progenitor Colonies" Blood.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Seiichi,Ishizuka; Noriyoshi,Kurihara; Yoshiyuki,Hakeda; Norihiko,Maeda; Katsumi,Ikeda; Masayoshi; Anthony W. Norman: "1alpha ,25-DihydroxyvitaminD<@D23@>D2[1alpha ,25-(OH)<@D22@>2D<@D23@>D2]-26, 23-Lactone Inhibits 1alpha ,25-(OH)<@D22@>D2D<@D23@>D2-Mediated Fustion of Mouse Bone Marrow Mononuclear Cells" Endocrinology. 123. 781-786 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kenji,Hiura; Koji,Sumitani; Terushige,Kawata; Kiyoshi,Higashino; Eiko,Kurihara; Takuya,Sato; Yoshiyuki,Hakeda; Masayoahi,Kumegawa: "Role of Mouse Osteoblastic Cells (MC3T3-E1) on Osteoblastic Cell Formation" Endocrinology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Eiko,Ikeda; Masami,Kusaka; Yoshiyuki,Hakeda; Kazushige,Yokota; Masayoshi,Kumegawa; Shozo,Yamamoto: "Effects of Interleukin 1 Beta on Osteoblastic MC3T3-E1 Cells" Calcif. Tissue int.43. 162-166 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] N.Kurihara,;T.Suda,;Y.Miura,H.;Kodama,;M.Kumegawa,: Bloos in press.

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Hiura,;K.Sumitani,;T.Kawata,;K.Higashino,;E.Kurihara,;T.Sato,;Y.Hakeda,;M.Kumegawa,: Endocrinology.

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Sumitani,;K.Hiura,;T.Kawata,;Y.Hakeda,;M.Kumegawa,: Endocrinology.

    • Related Report
      1988 Annual Research Report
  • [Publications] Eiko.Ikeda;Masami.Kusaka;Yoshiyuki.Hakeda;Kazushige.Yokota;Masayoshi.Kumegawa;Shozo.Yamamoto: Calcif Tissue Int.

    • Related Report
      1987 Annual Research Report
  • [Publications] Yoshiyuki.Hakeda;Takahiko.Hotta;Noriyoshi.Kurihara;Eiko.Ikeda;Norihiko.Maeda;Yoshihiro.Yagyu;Mashayoshi.Kumegawa: Endocrinology. 121. 1966-1974 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Noriyoshi.Kurihara;Toshio.Suda;Yasusada.Miura;Hiroaki.Kodama;Masayoshi.Kumegawa: Not decided.

    • Related Report
      1987 Annual Research Report
  • [Publications] Seiichi.Ishizuka;Noriyoshi.Kurihata;Shigeyasu.Hakeda;Norihiko.Maeda;Katshumi.Ikeda;Masayoshi.Kumegawa;Anthony W.Norman: Endocrinology.

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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