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Immunological studies of local antitumor effects by X ray irradiation

Research Project

Project/Area Number 62480405
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 外科・放射線系歯学
Research InstitutionOsaka University

Principal Investigator

SAKUDA Masayoshi  2ndDept.Oral&Maxillofacial Surg.Osaka Univ.Facul.of Dent. Prof., 歯学部, 教授 (00028755)

Co-Investigator(Kenkyū-buntansha) MORIYAMA Tomoji  2ndDept.Oral&Maxillofacial Surg.Osaka Univ.Facul. of Dent.Resident, 歯学部附属病院, 医員 (90314385)
NAKAZAWA Mitsuhiro  2ndDept.Oral&Maxillofacial Surg.Osaka Univ.Facul.of Dent. Resident, 歯学部附属病院, 医員 (70217701)
NUKATA Junichiro  2ndDept.Oral&Maxillofacial Surg.Osaka Univ.Facul.of Dent. Assist., 歯学部, 助手 (70189348)
SUGAHARA Toshio  2ndDept.Oral&Maxillofacial Surg.Osaka Univ.Facul.of Dent.Assoc.Prof., 歯学部, 助教授 (10116048)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥3,600,000 (Direct Cost: ¥3,600,000)
KeywordsLocal irradiation / Transplantable tumor / 癌免疫
Research Abstract

In order to investigate the effect of radiotherapy on the immunity in the tumor-bearing mice, the status of general immunity and local immune reaction were studied after irradiation of transplanted Meth-A tumor cells.
After local irradiation against the tumors transplanted onto the legs, the growth of the non-irradiated tumors transplanted into opposite side legs was suppressed. It was suggested that these anti-tumor effects after local tumor irradiation resulted from the anti-tumor immunity by mouse spleen lymphocytes, especially natural killer(NK)and t cells. At the same time, NK activity of spleen lymphocyte was also increased. The histological findings showed that lymphocyte infiltration into the tumor tissue was recognized at the earlier stage and more markedly in the non-irradiated opposite side leg tumor tissue of mice, of which leg tumors in another side were irradiated,than in the tumor tissue of non-irradiated mice. The immunohistological analysis revealed that the subpopulations of these infiltrated lymphocytes were composed of mainly NK and T cells.Still more, the growth of tumors at the pre-irradiated tissue were studied. Tumor growth at the pre-irradiated legs was suppressed in any cases of high-dose or low-dose irradiation.
It is suggested that, in the low-dose irradiation, the anttumor immunity mainly acted on the suppression of the tumor growth, and in the high-dose irradiation, suppression of the tumor growth was mainly induced by both the antitumor immunity and the radiation damage to blood vessels which was recognized in the histological analysis by the image analyzer.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Junichiro,Nukata: Cytoprotection and Cytobiology. 5. 107-115 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 足立寛: 日本口腔科学会雑誌. 36. 354-361 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 作田正義: 日本癌治癒学会雑誌. 22. 2376-2386 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 米田俊之: 日本口腔外科学会雑誌. 33. 1555-1565 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 作田正義: 日本口腔外科学会雑誌. 34. 51-55 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 西村理行: 日本口腔外科学会雑誌. 34. 586-591 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Junichiro, Nukata: "Effect of combined treatment with X-ray irradiation and Solcoseryl on immunity in tumor bearing mice." Cytoprotection and Cytobiology. 5. 107-115 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yutaka, Adachi: "Histopathological studies on oral malignant tumors of nonepithelial origin." J.Jpn.Stomatol.Soc.36. 354-361 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Masayoshi, Sakuda: "Studies of immunological status and prognosis on patients with head and nech cancer." J.Jpn.Soc.Cancer Ther.22. 2376-2386 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Masayoshi, Sakuda: "General complications with head and nech cancer patients." Jpn.J.Oral Maxillofac.Surg.33. 51-55 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Riko, Nishimura: "A clinical course of the patient with epidermiod carcinoma of the maxilla associated with marked leukocytosis and an establishment of experimental model in nude mice." Jpn.J.Oral Maxillofac.Surg.34. 586-591 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Junichiro Nukata: Cytsprotection and Cytobiology. 5. 107-115 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] 滝田正亮: 大阪大学歯学雑誌. 32. 530-546 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] 作田正義: 日本口腔外科学会雑誌. 34. 51-55 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 西村理行: 日本口腔外科学会雑誌. 34. 586-591 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 米田俊之: 日本口腔外科学会雑誌. 34. 826-831 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Tetsuo Ohnishi: European J.Phermacol.158. 173-175 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 中沢光博: 日本口腔外科学会雑誌. 33. 138-145 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 米田俊之: 日本口腔外科学会雑誌. 33. 1555-1565 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 足立寛: 日本口腔外科学会雑誌. 36. 354-361 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 額田純一郎: Cyto-protection & biolsgy. 5. 99-108 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 作田正義: 日本癌治療学会誌. 22. 2376-2386 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 作田正義: 日本口腔外科学会雑誌. 34. 51-55 (1988)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2017-04-05  

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