| Project/Area Number |
62480408
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
外科・放射線系歯学
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| Research Institution | HIGASHI NIPPON GAKUEN UNIVERSITY |
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Principal Investigator |
KOKUBU Masahiro Higashi Nippon Gakuen University,School of Dentistry, 歯学部, 助教授 (70124691)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥5,000,000 (Direct Cost: ¥5,000,000)
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| Keywords | RAST / Local anesthetics / Lidocaine / Procaine / Methylparaben / Ig E antibody / メチルパラベン / IgE抗体 / IgG抗体 |
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| Research Abstract |
Although anaphylactoid reactions to local anesthetics are well known, a radio allergosorbent test (RAST) to detect specific drug reagin (IgE) anti-body has not been developed. We established RAST for local anesthetics by using carboxylic acids derivatives of lidocaine, procaine and methylparaben. Serum samples were taken from 100 volunteers who had no allergies to the drugs used. Negative RAST values obtained from these volunteers were 1653 254 (SD) cpm(lidocaine), 2750 264cpm (procaine), and 2805 336cpm(msthylparaben).
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