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Pharmacological and Pharmacokinetic Studies on Anti-spastic Drugs

Research Project

Project/Area Number 62480420
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionThe University of Tokyo

Principal Investigator

FUKUDA Hideomi  Faculty of Pharmaceutical Sciences, The University of Tokyo, 薬学部, 教授 (50080172)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Kinzo  Faculty of Pharmaceutical Sciences, The University of Tokyo, 薬学部, 助手 (10114654)
ONO Hideki  Faculty of Pharmaceutical Sciences, The University of Tokyo, 薬学部, 助教授 (00080200)
HANANO Manabu  Faculty of Pharmaceutical Sciences, The University of Tokyo, 薬学部, 教授 (60012598)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 1988: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1987: ¥3,600,000 (Direct Cost: ¥3,600,000)
Keywordsantispastic drugs / muscle relaxants / noradrenaline / spinal cord / 2ーデオキシグルコース法 / バクロフェン / スリクロン / αアゴニスト / αアンタゴニスト
Research Abstract

Antispastic drugs have been used for the relief of elevated muscle tone in spastic paralysis and spinal cord injury. In the present research, the precise mechanisms of action of antispastic drugs have been studied.
1. Using spinal cord slices isolated from adult rats,alpha_1-agonistic action has been shown to enhance the spinal motorneuron activity.
2.alpha_2-Agonists reduced noradrenaline release from descending noradrenergic terminals in the spinal cord. These results suggest that alpha_1-agonistic action elevates muscle tone and that muscle relaxation caused by alpha_2-agonists is due to the decrease in noradrenaline release in the spinal cord.
3. The method which can be used for evaluation of the site of action (spinal or supraspinal level) of antispastic drugs was developed.
4. The mechanism of antispastic drugs was studied using nystagmus in rabbits.
5. 2-Deoxyglucose method was improved using [^3H]-3-O-methylglucose and [^<14>C]-2-deoxyglucose. The time required for measurement of glucose utilization was shortened to 5-10 min from 45 min. This method can be used for study of site of action of antispastic drugs.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] T.Kaneko: Arch.int.Pharmacodyn.287. 203-210 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] H.Ono: Arzneim-Forschung. 37. 384-388 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] H.Ono: Biomedical Res.9. 169-176 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T.Hirayama: Biomedical Res.9. 343-351 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] M.Ishikawa: General Pharmacol.20. 47-51 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 伊藤清美: 薬物動態. 3. 78-79 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kaneko, T.: "Simultaneous evaluation of drug effects on both the spinal cord and the descending pathway in rats." Arch. int Pharmacodyn.287. 203-210 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ono, H.: "Comparison of the effects of the new anxiolytic suriclone and benzodiazepines on motor function and electroencephalogram." Arzneim.-Forschung. 37. 384-388 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ono, H.: "alpha_2-Agonists-induced reduction of noradrenaline release from descending noradrenergic terminals in rat spinal cord: Functional relation to spinal motor system." Biomedical Res.9. 169-176 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hirayama, T.: "Effects of adrenergic agents on ventral horn cells in rat spinal cord slices." Biomedical Res.9. 343-351 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ishikawa, M.: "Effects of centrally acting muscle relaxants on post-rotatory nystagmus in the rabbit." General Pharmacol.20. 47-51 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T.Hirayama: Biomedical Res. 9. 343-351 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] M.Ishikawa: General Pharmacol. 20. 47-51 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 伊藤清美: 薬物動態. 3. 78-79 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Kaneko: Archives internationales de Pharmacodynatie et de Therapie. 287. (203-210)

    • Related Report
      1987 Annual Research Report
  • [Publications] HO.Ono: Arzneimittel-Forschung/Drug Research. 37(1). 384-388 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] H.Ono: Biomedical Research. 9. (1988)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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