| Project/Area Number |
62490014
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
広領域
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
KAWASHIMA Y Gifu Pharmaceutical University, 薬学部, 教授 (30082978)
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| Co-Investigator(Kenkyū-buntansha) |
HANDA T Kyoto University, Faculty of Pharmacy, 薬学部, 助教授 (00025719)
NIWA T Gifu Pharmaceutical University, 薬学部, 助手 (30198543)
HINO T Gifu Pharmaceutical University, 薬学部, 助手 (90208778)
TAKEUCHI H Gifu Pharmaceutical University, 薬学部, 講師 (50171616)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥5,500,000 (Direct Cost: ¥5,500,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥4,500,000 (Direct Cost: ¥4,500,000)
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| Keywords | Microspher / Amorphous / Controlled release / Bioavailability / Suspension / 晶析 / 多形 / アクリル酸ポリマー |
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| Research Abstract |
Novel preparation methods of high energy microspheres of pharmaceutics have been developed. Ibuprofen was molecularly dispersed in acrylic polymer sphere with higher energy, by dispersing ethanol solution of the drug and the polymer into aqueous medium with agitation. The microsphere can control the drug release rate depended or independed on pH. The controlled release suspension with improved bioavailability was prepared by dispersing the microsphere in aqueoud medium with water-soluble polymer. Spherically agglomerated crystals of tranilast was prepared by dispersing good solvent (ethanol-acetone-chlorform mixture) solution of the drug into poor solvent (water). The agglomerated crystals was monohydrate, which was converted to amorphous with high energy by drying. In conclusion a nlvel preparation method of high energy microsphere was developed by this project.
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