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Bioorganic chemistry of infection-inducing substances produced by phytopathogenic fungi.

Research Project

Project/Area Number 62490022
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 広領域
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

KONO Yoshiki  RIKEN, Lab. of Plant Growth Regulation senior scientist, 植物生活環制御研究室, 副主任研究員 (90087578)

Co-Investigator(Kenkyū-buntansha) SUZUKI Yoshikatsu  RIKEN, Lab. of Plant Growth Regulation scientist, 植物生活環制御研究室, 研究員 (00087579)
Project Period (FY) 1987 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 1989: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥2,900,000 (Direct Cost: ¥2,900,000)
Keywordsinfection-inducing substance / pathotoxin / host-specific toxin / HMT-toxin / PM-toxin / ACTG-toxin / HV-toxin / structure-activity relationship / HMTー毒素 / PMー毒素 / ACTGー毒素 / HVー毒素 / 構造ー活性相関 / 植物病原菌毒素 / HUー毒素
Research Abstract

Objective
Pathogenic action of microbes on plants are often highly host-specific. Not in many instances the mode of this specific action had been given chemical and biological basis, but some of the cases have been attributed to the production of host determinants (infection-inducing substances) such as host-specific toxic products (HST) by the microbes. In the presently proposed work the subjects of study are a) isolation and structure determination of ACTG-toxin and HV-toxin related components produced by the fungi A. citri and H. victoriae, which cause epidemic brown spot disease of Dancy tangerine and Victoria blight disease of oat, respectively, b) disease of Dancy tangerine or study of structure-bioactivity relationship of HMT- and PM-toxins produced by the fungi H. maydis, race T and Phyllosticta maydis, respectively, which cause epidemic blight-disease on the same species of corn , c) preliminary examinations of the culture conditions and bioassay methods in order to isolate new infection-inducing substances from fungi, except known HST producing fungi, such as P. oryzae and H. maydis, race O.
Results
a) Two minor ACTG-toxin related compounds (ACTG-toxin G and H) and a new sesquiterpenoid, dihydrosporogen AO-1, have been isolated and their structures have been determined. Structure of HV-toxin M was determined as a new victorin C related compound and HV-toxin H was identified with victorin C. Isolation of the other minor components of HV-toxin are in progress.
b) Thirty nine of HMT- and PM-toxin mimics have been systematically synthesized. Comparison of their biological activities suggested that bioactive conformations of HMT- and PM-toxins are certain cyclic forms.
c) Preliminary examination& of infection-inducing substances from P. oryzae and H. maydis, race 0 are in progress.

Report

(4 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • Research Products

    (43 results)

All Other

All Publications (43 results)

  • [Publications] 鈴木義勝: "Studies on the sonformations of PM-toxin,the host-Specific corn Pathotoxin produced by Phyllosticta maydis" Agric,Biol.Chem.,. 52. 15-24 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 鈴木義勝: "Synthesis and Biological Activity of a New Type of PM-Toxin Analogue Containing Oxygen Atoms in the Carbon-Chain Skeleton" Agric,Biol.Chem.,. 53. 453-459 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 佐々武史: "Chloromonilinic Acids A and B,Novel Catabolites of the Growth Self-inhibitor Chloromonilicin Isolated from Monilinia fructicola" Agric.Biol.Chem.,. 53. 1337-1341 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 河野芳樹: "Structure of amino acids isolated from hydroiyzed HV-toxin M,a host-specific toxin-related compoundproduced by Helminthosporium victoriae" Agric.Biol.Chem.,. 53. 505-511 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 河野芳樹: "New Minor Components of Host-Selctive ACTG-Tcxin and a Novel Sesquiterpene Produced by a Pathotype of Alternaria citri causing Brown Spot Disease of Mandarins" J.Pesticide Sci.,. 14. 223-228 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 木下武: "Structure of HV-toxin M,a Host-specific Toxin-related Compound Produced by Hilminthosprium victoriae" Agric.Biol.Chem.,. 53. 1283-1290 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 河野芳樹: "柴田承二編(続)生理活性天然物質(第2章2-3宿主特異的毒素)" 医歯薬出版株式会社, 9 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 河野芳樹: "NATO ASI Series,Vol.H-27,Phytotoxins and Pathogenesis,ed.by Graniti et,al." Springer-Verlag, 15 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Suzuki, L.W. Coleman, J.M. Daly, Y. Kono, H.W. Knoche, and S. Takeuchi: "Synthesis and Biological Activity of Mimics of PM-toxins, the Host-specific Corn Pathotoxin Produced by Phyllosticta maydis" Phytochemistry, 26, 687-696 (1987).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] S. Sekido, R. Suga, O. Kodama, T. Akatsuka, Y. Kono, Y. Esumi, and S. Takeuchi: "Qualitative and Semiquantative Analysis of Oryzalexins in Blast- or Brown Spot-Diseased Rice Leaves by Mass Chromatography" J. Pesticide Sci., 12, 739-740 (1987).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Suzuki, S.J. Danko, Y. Kono, J.M. Daly, H.W. Knoche, and S. Takeuchi: "Studies on the Conformations of PM-Toxin, the Host-specific Corn Pathotoxin Produced by Phyllosticta maydis" Agric. Biol. Chem., 52, 15-24 (1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Kono, J.M. Gardner, Y. Suzuki, H. Kondo, and S. Takeuchi: "New Minor Components of Host-Selective ACTG-Toxin and a Novel Sesquiterpene Produced by a Pathotype of Alteraria citri causing Brown Spot Disease of Mandarins" J. Pesticide Sci., 14, 223-228 (1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Kono, T. Kinoshita, S. Takeuchi, and J.M. Daly: "Structure of Amino Acids Isolated from Hydrolyzed HV-toxin M, a Host-Specific Toxin-Related Compound Produced by Helminthosporium victoriae" Agric. Biol. chem., 53, 505-511 (1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Suzuki, S.J. Danko, Y. Kono, J.M. Daly, H.W. Knoche, and S. Takeuchi: "Synthesis and Biological Activity of a New Type of PM-Toxin Analogue Containing Oxygen Atoms in the Carbon-Chain Skeleton" Agric. Biol. Chem., 53, 453-459 (1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Kinoshita, Y. Kono, S. Takeuchi, and J.M. Daly: "Structure of HV-toxin M, a Host-specific Toxin-related Compound produced by Helminthosporium victoriae" Agric. Biol. Chem., 53, 1283-1290 (1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Sassa, K. Horiguchi, and Y. Suzuki: "Chloromonilic Acids A and B, Novel Catabolites of the Growth Self-inhibitor Chloromonilicin Isolated from Monilinia fructicola" Agric. Biol. Chem., 53, 1337-1341 (1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K. Horiguchi, Y. Suzuki, and T. Sassa: "Biosynthetic Study of Chloromonilicin, a Growth Self-inhibitor Having a Novel Lactone Ring from Monilinia fructicola" Agric. Biol. Chem., 53, 2141-2145 (1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M. Watanabe, Y. Sakai, T. Teraoka, H. Abe, Y. Kono, J. Uzawa, K. Kobayashi, Y. Suzuki, and A. Sakurai: "A novel C_<19>-kaurane type diterpene (Oryzalide A), a new antimicrobial compound isolated from healthy leaves of bacterial leaf blight-resistant cultivar of rice plant" Agric. Biol. Chem., 54, in press (1990).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Kono and Y.Suzuki: "host-specific toxin", Bioactive natural products, ed. by S. Shibata. Ishiyaku-shuppan, 73-81 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Kono: "Structural studies on host-specific pathtoxins in corn blight and citrus brown spot diseases", Phytotoxins and Pathogenesis, Ed. by A. Graniti et al., NATO ASI Series, 27. Springer-Verlag, 7-21 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Kono, J.M.Gardner, Y.Suzuki and S.Takeuchi: "Structural studies on the phytotoxins produced by a pathotype of Alternaria citri causing a brown spot disease of mandarins", ibid.381 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Kono: "Some comments of future research on host-pathogen interactions in plant diseases", ibid.417-418 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 鈴木義勝: "Studies on the conformations of PM-toxin,the hostspecific corn pathotoxin produced by phyllosticta maydis" Agric,Biol.Chem.,. 52. 15-24 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 鈴木義勝: "Synthesis and Biological Activty of a New Type of PM-Toxin Analogue Containing Oxygen Atoms in the Carbon-Chain Skeleton" Agric.Biol.Chem.,. 53. 453-459 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 佐々武史: "Chloromonilinic Acids A and B,Novel Catabolites of the Growth Self-inhibitor Chloromonilicin Isolated from Monilinia fructicola" Agric.Biol.Chem.,. 53. 1337-1341 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 河野芳樹: "Structure of amino acids isolated from hydroiyzed HV-toxin M,a host-specific toxin-related compoundproduced by Helminthosporium victoriae" Agric.Biol.Chem.,. 53. 505-511 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 河野芳樹: "New Minor Components of Host-Selective ACTG-Toxin and a Novel Sesquiterpene Produced by a Pathotype of Alternaria citri causing Brown Spot Disease of Mandarins" J.Pesticide Sci.,. 14. 223-228 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 木下武: "Structure of HV-toxin M,a Host-specific Toxin-related Compound produced by Helminthosporium victoriae" Agric.Biol.Chem.,. 53. 1283-1290 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 河野芳樹: "柴田承二編(続)生理活性天然物質(第2章2ー3宿主特異的毒素)" 医歯薬出版株式会社, 9 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 河野芳樹: "MATO ASI Series,Vol.H-27,Phytotoxins and pathogenesis,ed.by Graniti et.al." Springer-Verlag, 15 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 鈴木義勝: Phytochemistry. 26. 687-696 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] 鈴木義勝: Agric.Biol.Chem.52. 15-24 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 関戸治知: J.Pesticide Sci.12. 739-740 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] 河野芳樹: Agric.Biol.Chem.53. 505-511 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 河野芳樹: J.Pesticide Sci.

    • Related Report
      1988 Annual Research Report
  • [Publications] 木下武: Agric.Biol.Chem.

    • Related Report
      1988 Annual Research Report
  • [Publications] 河野芳樹: "柴田承二 編第2章2-3宿主特異的毒素(続)生理活性天然物質" 医歯薬出版株式会社, 73-81 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 河野芳樹: "NATO ASI series,Vol.H-27"Phytotoxins and Pathogenesis""Structural studies on the host-specific pathofoxins from corn blight and citrus brown spot disease"" Springer-Verlag, 7-21 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 鈴木義勝: Phytochemistry. 26. 687-696 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 鈴木義勝: Agric.Biol.Chem.52. 15-24 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] 関戸治知: J.Pesticide Sci. 12. 739-740 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 河野茂樹: "柴田〓二編 第2章2-3宿主特異的毒素(続)生理活性天然物資" 医歯薬出版株式会社,

    • Related Report
      1987 Annual Research Report
  • [Publications] 河野茂樹: "Phytotoxins and Plant pasthogenesis ;NATO adianced research Workshop Structural Studies on the host-specific pathotoxins from cornblight and atrus brown spct disease" Springer Verlag,

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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