| Project/Area Number |
62560092
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
応用生物化学・栄養化学
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| Research Institution | University of Occupational and Environmental Health |
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Principal Investigator |
NISHIHARA Masateru School of Medicine, Univ. Occup. Env. Health, 医学部, 講師 (20131930)
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| Co-Investigator(Kenkyū-buntansha) |
MORII Hiroyuki School of Nursing and Medical Technology, Univ. Occup. Env. Health, 助手 (60141743)
KOGA Yosuke School of Medicine, Univ. Occup. Env. Health, 医学部, 教授 (70012458)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1988: ¥400,000 (Direct Cost: ¥400,000)
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| Keywords | Archaebacteria / Methanogen / Ether lipids / Lipid structure / M.thermoautotrophicum |
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| Research Abstract |
The strucutres of major tetraether types of lipids in the methanogen methanobacterium thermoautotrophicum were elucidated. The systematic names of these lipids were caldarchaeol, gentiobiosyl caldarchaeol, caldarchaetidyl-X and gentiobiosyl caldarchaetidyl-X (X=ethanol-amine, L-serine and myo-inositol). These lipids were classifies in three (ethanolamine, serins and inositol) groups of quartets, each of which is composed of neutral lipids, glycolipids, phospolipid and phosphoglycolipid.
The structural features of the quartet provided useful clues for elucidation and understanding of the complexity of lipid pattern of this organism and biosynthetic hypothesis. The quartet concept was extended to a heptad concept by the addition of the results of structural analysis of diether polar lipids.
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