Search for Antifungal Substances from Marine Invertebrates
| Project/Area Number |
62560206
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Fisheries chemistry
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| Research Institution | University of Tokyo |
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Principal Investigator |
FUSETANI Nobuhiro Faculty of Agriculture, University of Tokyo, 農学部, 助教授 (70012010)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1988: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1987: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Marine Invertebrates / Spnges / Gorgonians / Antifungal Activity / Candida / Mortierella / Penicillum / Petrosia / Mycale / Acalycigorgia / Polyacetylene Alcohol / Acalycixeniolide / トゲナシヤギ / ノルジテルペン / Petrosia / ポリアセチレンアルコール |
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| Research Abstract |
Marine invertebrates, mainly sponges and coelenterates (143 specimens) have been collected from various places including Izu peninsula, Hachijo Island, Kii Peninsula and Shikoku coasts, and examined for antifungal activity against Candida albicans, Mortierella ramannianus and Penicillium chrysogenum. Many sponges were found to be promising as a source of antifungal agents.
The following 9 antifungal substances have been isolated from active specimens and their structures elucidated mainly by spctroscopic analyses: Petrosynol (1) from a sponge Petrosia sp. collected in Hachijo Island, acalycixeniolides A (2) and B (3) from the gorgonian Acalycigorgia inermis collected in Izu Peninsula, ginamallene (4), acalycixeniolides B' (5) and C (6) from Acalycigorgia sp., and mycalolides A - C (7 - 9) from a sponge of genus Mycale collected in Kii Peninsula.
KA
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Report
(3 results)
Research Products
(15 results)
