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STUDIES ON TOXIC AGENT IN LOWER BENTHIC ANIMALS INHABITING IN THE SETO INLAND SEA, ESPECIALLY ON TETRODOTOXIN OF THE FLATWORM

Research Project

Project/Area Number 62560211
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Fisheries chemistry
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

MIYAZAWA Keisuke  APPLIED BIOLOGICAL SCIENCE, HIROSHIMA UNIVERSITY, Prof., 生物生産学部, 教授 (20034457)

Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1988: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1987: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsTetrodotoxin / distribution of toxicity / Echinodermata / Platyhelminthes / 棘皮動物 / 紐形動物 / テトロドトキシン / 部位別毒生
Research Abstract

In order to clarify the distribution, origin and mechanism of accumulation of tetrodotoxin (TTX) in the lower benthic animals in the Seto Inland Sea, some examinations were performed and following results were obtained.
1. Among the various organs of the starfish Astropecten polyacanthus, ovary showed the highest potency (max. 12700 MU/g) followed by digestive organs. As the result, overall toxicity was remarkably higher in female than in male.
2. Among the various tissues of the flatworm planocera multitentaculate, oviduct was most toxic, followed by digestive organs. The egg masses laid exhibited extremely high potency upto 10700 MU/g. These rusults suggested that the flatworm and the starfish possess TTX as defense or alarm substance against predators. Some TTX-producing bacteria were isolated from the digestive tract of flatworm.
3. Ribbon worms, Lineus fuscoviridis, Tubulanus punctatus and some others, had lethal potencise. The toxios were partially purified and identified as TTX and its relating substances by TLC, HPLC and GC-MS. This may be the first finding of TTX in Nemertini.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] K.Miyazawa;J.K.Jeon;T.Noguchi;K.Ito;K.Hashimoto: TOXICON. 25. 975-980 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K.Miyazawa;M.Higashiyama;K.Hori;T.Noguchi;K.Ito;K.Hashimoto: MARINE BIOLOGY. 96. 385-390 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K.Miyazawa;M.Higashiyama;K.Ito;T.Noguchi;O.Arakawa;Y.Shida;K.Hashimoto: TOXICON. 26. 867-874 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T.Noguchi;K.Miyazawa,et al.: Progress in venom and toxin research. 336-347 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K. Miyazawa; J.K. Jeon; T. Noguchi; K. Ito; K. Hashimoto: "DISTRIBUTION OF TETRODOTOXIN IN THE TISSUES OF THE FLATWORM PLANOCERA MULTITENTACULATA (PLATYHELMINTHES)" TOXICON. 25. 975-980 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K. Miyazawa; M. Higashiyama; K. Hori; T. Noguchi; K. Ito; K. Hashimoto: "DISTRIBUTION OF TETRODOTOXIN IN VARIOUS ORGANS OF THE STARFISH ASTROPECTEN POLYACANTHUS" MARINE BIOLOGY. 96. 385-390 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K. Miyazawa; M. Higashiyama; K. Ito; T. Noguchi; O. Arakawa; Y. Shida; K. Hashimoto: "TETRODOTOXIN IN TWO SPECIES OF RIBBON WORM (NEMERTINI) LINEUS FUSCOVIRIDIS AND TUBULANUS PUNCTATUS" TOXICON. 26. 867-874 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T. Noguchi; D.F. Hwang; O. Arakawa; H. Sugita; Y. Deguchi; H. Narita; U. Shimidu; A. Kunguswan; K. Miyazawa; K.Hashimoto: "TETRODOTOXIN-PRODUCING ABILITY OF BACTERIA ISOLATED FROM SEVERAL MARINE ORGANISMS" PROGRESS IN VENOM AND TOXIN RESEARCH. 336-347 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K.Miyazawa;J.K.Jeon;T.Noguchi;K.Ito;K.Hashimoto.: TOXICON. 25. 975-980 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Miyazawa;M.Higashiyama;K.Hori;T.Noguchi;K.Ito;K.Hashimoto.: MARINE BIOLOGY. 96. 385-390 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Miyazawa;M.Higashiyama;K.Ito;T.Noguchi;O.Arakawa;K.Hashimoto.: TOXICON. 26. 867-874 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Noguchi,etal.K.Miyazawa.: Progress in venom and toxin research. 336-347 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] K. Miyazawa;M. Higashiyama;K. Ito;T. Noguchi;O. Arakawa;Y. Shida;K. Hashimoto: Toxicon.

    • Related Report
      1987 Annual Research Report
  • [Publications] K. Miyazawa;M. Higashiyama;K. Hori;T. Noguchi;K. Ito;K. Hashimoto: Marine Biology. 96. 385-390 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] K. Miyazawa;J.K. Jeon;T. Noguchi;K. Ito;K. Hashimoto: Toxicon. 25. 975-980 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] K. Miyazawa;J.K. Jeon;J. Maruyama;T. Noguchi;K. Ito;K. Hashimoto: Toxicon. 24. 645-650 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] J.K. Jeon;K. Miyazawa;T. Noguchi;H. Narita;s. Matsubara;M. Nara;K. Ito;K. Hashimoto: Nippon Suisan Gakkaishi. 52. 1065-1069 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] K. Miyazawa;T. Noguchi;J. Maruyama;J.K. Jeon;M. Otsuka;K. Hashimoto: Marine Biology. 90. 61-64 (1985)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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