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Enzymatic Synthesis of Functional Oligosaccharides from Lactulose.

Research Project

Project/Area Number 62560279
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 畜産化学
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

SUYAMA Kyozo  Associate Professor Tohoku University, Faculty of Agricultuutre, 農学部, 助教授 (70005635)

Co-Investigator(Kenkyū-buntansha) SUGAWARA Hiroshi  Asistant Fac. Agriculture, Tohoku Univ., 農学部, 教務職員 (80089797)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1988: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1987: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywordslactulose / galacto-oligosaccharides / Bifidus activity / 糖転移反応 / ビフィダス活性 / ガラクトシル転移反応 / オリゴ糖 / β-ガラクトシダーゼ
Research Abstract

Lactulose has acquired a broad range of usefulness; bifidus factor in maintaining the normal intestinal microflora of infant and also adult, reduction the frequency of recurrences of encephalophthy and permits increased dietary protein consumption in the great majority of such patients, less well defined severe exacerbations of nitrogenous portal-systemic encephalopathy.
In this report, isolation and characterization of oligosaccharides formed by the transgalactosylation reaction of lactulose catalyzed by Aspergillus oryzae -galactosidase were described. Major Tri-, tetra- and pentasaccharide has been isolated by charcoal column and preparative paper chromatography and shown to have the structure: O- -D-galactopyranosyl-(1---6)-O- -D-galacto-pyranosyl-(1---4)-D-fructose(TR), O- -D-galactopyranosyl-(1---6)-O- -D-galacto-pyranosyl-(1---6)-O- -D-galactopyranosyl-(1---4)-D-fructose(TE), and O- -D-galactopyranosyl-(1---6)-O- -D-galactopylanosyl-(1---6)-O- -D-galactopyranosyl-(1---6)-O- -D-galactopyranosyl-(1---4)-D-fructose(PE).
In attempt to produce oligosaccharides in medium containing lacturose, an Aspergillus oryzae S-65 screened from 25 aspergillus species and 24 Aspergillus oryzae strains accumulate in large quantities of galacto oligosaccharides from lactulose. The most abundant oligosaccharide formed were TR and TE. A Cryptococcus laurentii also produced oligosaccharides in lacturose containing medium. The yield of trisaccharides was 15.5 per cent based on total saccharides. The main product formed was A hitherto undescrided trisaccharide, O- -D-galactopyranosyl-(1---4)-O- -D-galactopyranosyl-(1---4)-D-fructose.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] Kyozo Suyama,;Chien-J-Hwang,;Susumu Adachi.: Analytical Biochemistry. 162. 325-329 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kyozo Suyama,;Susumu Adachi.: Journal of Chromatographic Science. 25. 130-131 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kyozo Suyama,;Eiji Kusakari,;Susumu Adachi.: Milchwissenshaft.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kyozo Suyama,;Hirosi Sugawara.: Jouenal of Agricultural and Food Chemistry.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kyozo Suyama,;Yoshiyuki Matumoto.: Journal of Agricultural and Food Chemistry.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kyozo Suyama; Chien J. Hwang; Susumu Adachi: "Isolation of ketoses and nonreducing sugars from a suga mixture containing aldose by aniline treatment." Analytical Biochemistry. 162. 325-329 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kyozo Suyama; Susumu Adachi: "A simple method for the visualization of the separated zones of sugars on silica gel plate without spray reagent." Journal of Chromatographic Science. 25. 130-131 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kyozo Suyama; Eiji Kusakari; Susumu Adachi: "Oligosaccharides formed by the transgalactosylation of lactulose by Aspergillus oryzae beta-galactosidase." Milchwissenshaft.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kyozo Suyama; Hiroshi Sugawara: "Characterization of some galacto oligosaccharides formed from lactulose by growing culture of Aspergillus oryzae." Journal of Agricultural and Food Chemistry.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kyozo Suyama; Yoshiyuki Matumoto: "4'-galctosyl lactulose formed from lactulose by growing culture of Cryptococcus laurentii." Journal of Agricultural and Food Chemistry.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kyozo,Suyama;Chien-J-Hwang;Susumu,Adachi: A naly tical Biochemistry. 162. 325-329 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kyozo,Suyama;Susumu,Adachi: J.Chuomato gvaphic Science. 25. 130-131 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kyozo,Suyama;Eiji,Kusakari;Susumu Adachi: Milchwissenshaft.

    • Related Report
      1988 Annual Research Report
  • [Publications] Kyozo,Suyama;Hiroshi,Sugawara: Journal of Agricultural and Food Chemistry.

    • Related Report
      1988 Annual Research Report
  • [Publications] Kyozo,Suyama;Yoshiyuki,Matumoto: Journal of Agricultural and Food Chemistry.

    • Related Report
      1988 Annual Research Report
  • [Publications] Kyozo Suyama, Eizi Kusahari and Susumu Adachi: Agriculural and Biological Chemistry.

    • Related Report
      1987 Annual Research Report
  • [Publications] Kyozo Suyama, Chien-jung, Toshihiro Fujii and Susumu Adachi: Avalytical Biochemistry. 162. 162-166 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Kyozo Suyana and Susumu Adachi: Journal of Chronatognaphic Science. 25. 130-132 (1987)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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