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Establishment of animal model for gastro-enteritis induced by Campylobacter pylori using germfree animals

Research Project

Project/Area Number 62570159
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionNagoya University

Principal Investigator

NAGURA Hiroshi  Nagoya University, Professor, 医学部, 教授 (90022821)

Co-Investigator(Kenkyū-buntansha) ITO Masabumi  Nagoya University, Research associate, 医学部, 助手 (50184693)
OOTA Michio  Nagoya University, Associate professor, 医学部, 助教授 (20111841)
SUMI Yukiko  Nagoya University, Associate Professor, 医学部, 助教授 (00022806)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1988: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1987: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsCampylobacter pylori / Germfree animal / Chronic gastritis / Immunohistochemistry / Gut-associated lymphoid tissue / Local immune system / T lymphocyte / 免疫グロブリン / IgA / IgG
Research Abstract

The aim of this research project was to establish an animal model for gastroenteritis induced by Campylobacter pyloridis (c. pylori), and to observe the immune responses to these organisms.
In germfree animals, the lymphoid tissue in gastro-intestinal mucosa (GALT) was poorly developed, and the expression of Ia-antigens by villous epithelium was almost absent. By the administration of the microorganisms, galt was rapidly developed, and numbers of IgA plasma cells and T lymphocytes were much increased. Ia-antigens appeared in the villous epithelium.
In man, gastric mucosa positive for C. pylori, hyperplasia of the foveolar epithelium and remarkable increase of IgA and IgG plasma cells and leucocytes were observed. The number of T lymphocytes in the C. pylori-infected mucosa did not grow larger. This suggests that the C. pylori-infection induce humoral immune responses and inflammation, and proliferative changes of the foveolar gland in the gastric mucosa.
These results may give an important clue to elucidate the mechanism of inflammatory and ulcerative diseases in the stomach.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 中村司朗 他: 消化器と免疫. 20. 189-193 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nakamura,S.,et al.: Acta Pathol.Jpn.38. 1267-1283 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nagura,H.,et al.: Toxicologic Pathol.16. 154-164 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 名倉宏 他: 消化器と免疫. 22. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nakamura, S., et al.: "Immunohistochemical analysis of ontogenic development of GALT in neonatal rats." Digestive Organ and Immunology. 20. 189-193 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nakamura, S., et al.: "Ontogenic development of gut-associated lymphoid tissue in the rat." Acta Pathol. Jpn.38. 1267-1283 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nagura, H., et al.: "Immunologic function of the gut--Role of the mucosal immune system." Toxicologic Pathol.16. 154-164 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nagura, H., et al.: "Immune responses in gastric mucosa against Compylobactrer-like organisms." Digestive Organ and Immunology. 22. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Nagura, H., et al.: Digestive Disease Pathology vol.1. Field and Wood Inc., 185-205 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 名倉宏 他: 消化器と免疫. 22. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Nagura,H.,etal.: "Digestive Disease Pathology,vol.1" Field and Wood Inc., 185-205 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 中村司朗, 鷲見幸子, 名倉宏: 消化器と免疫. 20. 189-193 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Hirishi Nagura;Yukiko Sumi: Toxicologic Pathology. 16. (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Hirishi Nagura;Yukiko Sumi;Shiro Nakamura: Fourth International Conference on Immunopathology. (1988)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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